Green's function probe of a static granular piling

We present an experiment which aim is to investigate the mechanical properties of a static granular assembly. The piling is an horizontal 3D granular layer confined in a box, we apply a localized extra force at the surface and the spatial distribution of stresses at the bottom is obtained (the mechanical Green's function). For different types of granular media, we observe a linear pressure response which profile shows one peak centered at the vertical of the point of application. The peak's width increases linearly when increasing the depth. This green function seems to be in -at least- qualitative agreement with predictions of elastic theory.Comment: 9 pages, 3 .eps figures, submitted to PR

Effective management of part-time lecturers

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Engaging with the Learning Gateway A guide for colleges

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Hypoxia Promotes Dissemination of Multiple Myeloma Through Acquisition of Epithelial to Mesenchymal Transition-like Features

The spread of multiple myeloma (MM) involves (re)circulation into the peripheral blood and (re)entrance or homing of MM cells into new sites of the BM. Hypoxia in solid tumors was shown to promote metastasis through activation of proteins involved in the epithelial-mesenchymal transition (EMT) process. We hypothesized that MM-associated hypoxic conditions activate EMT-related proteins and promote metastasis of MM cells. In the present study, we have shown that hypoxia activates EMT-related machinery in MM cells, decreases the expression of E-cadherin, and, consequently, decreases the adhesion of MM cells to the BM and enhances egress of MM cells to the circulation. In parallel, hypoxia increased the expression of CXCR4, consequently increasing the migration and homing of circulating MM cells to new BM niches. Further studies to manipulate hypoxia to regulate tumor dissemination as a therapeutic strategy are warrante