WFMOS - Sounding the Dark Cosmos

Vast sound waves traveling through the relativistic plasma during the first million years of the universe imprint a preferred scale in the density of matter. We now have the ability to detect this characteristic fingerprint in the clustering of galaxies at various redshifts and use it to measure the acceleration of the expansion of the Universe. The Wide-Field Multi-Object Spectrograph (WFMOS) would use this test to shed significant light on the true nature of dark energy, the mysterious source of this cosmic acceleration. WFMOS would also revolutionise studies of the kinematics of the Milky Way and provide deep insights into the clustering of galaxies at redshifts up to z~4. In this article we discuss the recent progress in large galaxy redshift surveys and detail how WFMOS will help unravel the mystery of dark energy.Comment: 6 pages, pure pdf. An introduction to WFMOS and Baryon Acoustic Oscillations for a general audienc

「アジア債権市場」を考える : 現実的フィージビリティからの考察

はじめに　1. アジアにおける資金移動の状況と債券市場整情の必要性　2. 「アジア債券市場」推進，支援活動の状況　3. ABFの有効性　4. 提言:東京市場の「ユーロ市場」化　結語

Dark Energy and Cosmic Sound: w(z) Surveys with the Gemini/Subaru Wide-Field Multi-Object Spectrograph

This white paper gives an overview of the proposed Gemini/Subaru Wide-Field Multi-Object Spectrograph (WFMOS) and the proposed redshift surveys of 2.6 million galaxies with 0.5<z<3.3 over 2000 deg^2 of sky. These surveys will probe the baryonic acoustic oscillations in the galaxy power spectrum with unprecedented precision and over a range of redshifts and deliver dark energy w(z) constraints an order of magnitude better than current limits. We discuss the requirements on precursor observations and on calibrations, the systematics in the method and the quantitative precision obtainaible in distance-redshift and expansion-rate-redshift measurements which feed in to the w(z) precision. We also outline the technological and scientific strengths and risks which might be associated with the project and the relationship of WFMOS to other baryon oscillation experiments.Comment: White paper submitted to the Dark Energy Task Force. 13 page

Drug Susceptibility Patterns of Mycobacterium Tuberculosis from Adults With Multidrug-Resistant Tuberculosis and Implications for a Household Contact Preventive Therapy Trial

BACKGROUND: Drug susceptibility testing (DST) patterns of Mycobacterium tuberculosis (MTB) from patients with rifampicin-resistant tuberculosis (RR-TB) or multidrug-resistant TB (MDR-TB; or resistant to rifampicin and isoniazid (INH)), are important to guide preventive therapy for their household contacts (HHCs). METHODS: As part of a feasibility study done in preparation for an MDR-TB preventive therapy trial in HHCs, smear, Xpert MTB/RIF, Hain MTBDRplus, culture and DST results of index MDR-TB patients were obtained from routine TB programs. A sputum sample was collected at study entry and evaluated by the same tests. Not all tests were performed on all specimens due to variations in test availability. RESULTS: Three hundred eight adults with reported RR/MDR-TB were enrolled from 16 participating sites in 8 countries. Their median age was 36 years, and 36% were HIV-infected. Routine testing on all 308 were confirmed as having RR-TB, but only 75% were documented as having MDR-TB. The majority of those not classified as having MDR-TB were because only rifampicin resistance was tested. At study entry (median 59 days after MDR-TB treatment initiation), 280 participants (91%) were able to produce sputum for the study, of whom 147 (53%) still had detectable MTB. All but 2 of these 147 had rifampicin DST done, with resistance detected in 89%. Almost half (47%) of the 147 specimens had INH DST done, with 83% resistance. Therefore, 20% of the 280 study specimens had MDR-TB confirmed. Overall, DST for second-line drugs were available in only 35% of the 308 routine specimens and 15% of 280 study specimens. CONCLUSIONS: RR-TB was detected in all routine specimens but only 75% had documented MDR-TB, illustrating the need for expanded DST beyond Xpert MTB/RIF to target preventive therapy for HHC

The double-design dilemma : political science, parliamentary crisis and disciplinary justifications

Two separate, but inter-linked, dilemmas have highlighted the importance of design-led thinking. First, the crumbling physical fabric of the Palace of Westminster has prompted a multi-billion rebuilding project, which will require the parliamentary studies specialism to engage with questions of design, space, and architecture. Separately, political science more generally has been challenged to utilize the insights of design-thinking and design-practice: a challenge to which it is culturally and methodological ill-equipped. This article considers what a design-led approach to political science looks like in theory, and in practice, in the case study of the Restoration and Renewal of the Palace of Westminster. This represents a first attempt at how such a fusion could be beneficial for both politics as theory and politics as practice. The main conclusion is that although design-orientated political science is not a panacea for the challenges of modern democratic governance – in intellectual or practical terms – it does appear to offer significant potential in terms of theoretically-informed but solution focused research