126 research outputs found
The Effect of the Third Dimension on Rough Surfaces Formed by Sedimenting Particles in Quasi-Two-Dimensions
The roughness exponent of surfaces obtained by dispersing silica spheres into
a quasi-two-dimensional cell is examined. The cell consists of two glass plates
separated by a gap, which is comparable in size to the diameter of the beads.
Previous work has shown that the quasi-one-dimensional surfaces formed have two
distinct roughness exponents in two well-defined length scales, which have a
crossover length about 1cm. We have studied the effect of changing the gap
between the plates to a limit of about twice the diameter of the beads.Comment: 4 pages, 4 figures, submitted to IJMP
Drift without flux: Brownian walker with a space dependent diffusion coefficient
Space dependent diffusion of micrometer sized particles has been directly
observed using digital video microscopy. The particles were trapped between two
nearly parallel walls making their confinement position dependent.
Consequently, not only did we measure a diffusion coefficient which depended on
the particles' position, but also report and explain a new effect: a drift of
the particles' individual positions in the direction of the diffusion
coefficient gradient, in the absence of any external force or concentration
gradient.Comment: 4 pages, 4 ps figures, include
Influence of flow confinement on the drag force on a static cylinder
The influence of confinement on the drag force on a static cylinder in a
viscous flow inside a rectangular slit of aperture has been investigated
from experimental measurements and numerical simulations. At low enough
Reynolds numbers, varies linearly with the mean velocity and the viscosity,
allowing for the precise determination of drag coefficients and
corresponding respectively to a mean flow parallel and
perpendicular to the cylinder length . In the parallel configuration, the
variation of with the normalized diameter of the
cylinder is close to that for a 2D flow invariant in the direction of the
cylinder axis and does not diverge when . The variation of
with the distance from the midplane of the model reflects the
parabolic Poiseuille profile between the plates for while it
remains almost constant for . In the perpendicular configuration,
the value of is close to that corresponding to a 2D system
only if and/or if the clearance between the ends of the cylinder
and the side walls is very small: in that latter case,
diverges as due to the blockage of the flow. In other cases, the
side flow between the ends of the cylinder and the side walls plays an
important part to reduce : a full 3D description of the flow is
needed to account for these effects
Diffusion in pores and its dependence on boundary conditions
We study the influence of the boundary conditions at the solid liquid
interface on diffusion in a confined fluid. Using an hydrodynamic approach, we
compute numerical estimates for the diffusion of a particle confined between
two planes. Partial slip is shown to significantly influence the diffusion
coefficient near a wall. Analytical expressions are derived in the low and high
confinement limits, and are in good agreement with numerical results. These
calculations indicate that diffusion of tagged particles could be used as a
sensitive probe of the solid-liquid boundary conditions.Comment: soumis \`a J.Phys. Cond. Matt. special issue on "Diffusion in
Liquids, Polymers, Biophysics and Chemical Dynamics
Association of Coronary Microvascular Dysfunction With Heart Failure Hospitalizations and Mortality in Heart Failure With Preserved Ejection Fraction:A Follow-up in the PROMIS-HFpEF Study
Background: Coronary microvascular dysfunction (CMD) is common in heart failure with preserved ejection fraction (HFpEF). We assessed the association of CMD with hospitalization and mortality in HFpEF. Methods and Results: We assessed the 1-year outcomes in patients from the PROMIS-HFpEF study, a prospective observational study of patients with chronic stable HFpEF undergoing coronary flow reserve measurements. Outcomes were (1) time to cardiovascular (CV) death/first HF hospitalization, (2) CV death/recurrent HF hospitalizations, (3) all-cause death/first HF hospitalization, and (4) first and (5) recurrent all-cause hospitalizations. CMD was defined as coronary flow reserve of Conclusions: In this exploratory assessment of the prognostic role of CMD in HFpEF, CMD was independently associated with primarily CVand HF-specific events. The high prevalence of CMD and its CV and HF specific prognostic role suggest CMD may be a potential treatment target in HFpEF
Disproportionate left atrial myopathy in heart failure with preserved ejection fraction among participants of the PROMIS-HFpEF study
Impaired left atrial (LA) function in heart failure with preserved ejection fraction (HFpEF) is associated with adverse outcomes. A subgroup of HFpEF may have LA myopathy out of proportion to left ventricular (LV) dysfunction; therefore, we sought to characterize HFpEF patients with disproportionate LA myopathy. In the prospective, multicenter, Prevalence of Microvascular Dysfunction in HFpEF study, we defined disproportionate LA myopathy based on degree of LA reservoir strain abnormality in relation to LV myopathy (LV global longitudinal strain [GLS]) by calculating the residuals from a linear regression of LA reservoir strain and LV GLS. We evaluated associations of disproportionate LA myopathy with hemodynamics and performed a plasma proteomic analysis to identify proteins associated with disproportionate LA myopathy; proteins were validated in an independent sample. Disproportionate LA myopathy correlated with better LV diastolic function but was associated with lower stroke volume reserve after passive leg raise independent of atrial fibrillation (AF). Additionally, disproportionate LA myopathy was associated with higher pulmonary artery systolic pressure, higher pulmonary vascular resistance, and lower coronary flow reserve. Of 248 proteins, we identified and validated 5 proteins (involved in cardiomyocyte stretch, extracellular matrix remodeling, and inflammation) that were associated with disproportionate LA myopathy independent of AF. In HFpEF, LA myopathy may exist out of proportion to LV myopathy. Disproportionate LA myopathy is a distinct HFpEF subtype associated with worse hemodynamics and a distinct proteomic signature, independent of AF
A prospective study of nutrition education and oral nutritional supplementation in patients with Alzheimer's disease
<p>Abstract</p> <p>Background</p> <p>Weight loss in patients with Alzheimer's disease (AD) is a common clinical manifestation that may have clinical significance.</p> <p>Objectives</p> <p>To evaluate if there is a difference between nutrition education and oral nutritional supplementation on nutritional status in patients with AD.</p> <p>Methods</p> <p>A randomized, prospective 6-month study which enrolled 90 subjects with probable AD aged 65 years or older divided into 3 groups: Control Group (CG) [n = 27], Education Group (EG) [n = 25], which participated in an education program and Supplementation Group (SG) [n = 26], which received two daily servings of oral nutritional supplementation. Subjects were assessed for anthropometric data (weight, height, BMI, TSF, AC and AMC), biochemical data (total protein, albumin, and total lymphocyte count), CDR (Clinical Dementia Rating), MMSE (Mini-mental state examination), as well as dependence during meals.</p> <p>Results</p> <p>The SG showed a significant improvement in the following anthropometric measurements: weight (H calc = 22.12, p =< 0.001), BMI (H calc = 22.12, p =< 0.001), AC (H calc = 12.99, p =< 0.002), and AMC (H calc = 8.67, p =< 0.013) compared to the CG and EG. BMI of the EG was significantly greater compared to the CG. There were significant changes in total protein (H calc = 6.17, p =< 0.046), and total lymphocyte count in the SG compared to the other groups (H cal = 7.94, p = 0.019).</p> <p>Conclusion</p> <p>Oral nutritional supplementation is more effective compared to nutrition education in improving nutritional status.</p
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