228 research outputs found
Subharmonic Almost Periodic Functions of Slow Growth
We obtain a complete description of the Riesz measures of almost periodic
subharmonic functions with at most of linear growth on the complex plane; as a
consequence we get a complete description of zero sets for the class of entire
functions of exponential type with almost periodic modulus
Bochner transforms, perturbations and amoebae of holomorphic almost periodic mappings in tube domains
We give an alternative representation of the closure of the Bochner transform
of a holomorphic almost periodic mapping in a tube domain. For such mappings we
introduce a new notion of amoeba and we show that, for mappings which are
regular in the sense of Ronkin, this new notion agrees with Favorov's one. We
prove that the amoeba complement of a regular holomorphic almost periodic
mapping, defined on Cn and taking its values in Cm+1, is a Henriques m-convex
subset of Rn. Finally, we compare some different notions of regularity
Activity of Somatosensory-Responsive Neurons in High Subdivisions of SI Cortex during Locomotion
Responses of neurons in the primary somatosensory cortex during movements are poorly understood, even during such simple tasks as walking on a flat surface. In this study, we analyzed spike discharges of neurons in the rostral bank of the ansate sulcus (areas 1–2) in 2 cats while the cats walked on a flat surface or on a horizontal ladder, a complex task requiring accurate stepping. All neurons (n = 82) that had receptive fields (RFs) on the contralateral forelimb exhibited frequency modulation of their activity that was phase locked to the stride cycle during simple locomotion. Neurons with proximal RFs (upper arm/shoulder) and pyramidal tract-projecting neurons (PTNs) with fast-conducting axons tended to fire at peak rates in the middle of the swing phase, whereas neurons with RFs on the distal limb (wrist/paw) and slow-conducting PTNs typically showed peak firing at the transition between swing and stance phases. Eleven of 12 neurons with tactile RFs on the volar forepaw began firing toward the end of swing, with peak activity occurring at the moment of foot contact with floor, thereby preceding the evoked sensory volley from touch receptors. Requirement to step accurately on the ladder affected 91% of the neurons, suggesting their involvement in control of accuracy of stepping. During both tasks, neurons exhibited a wide variety of spike distributions within the stride cycle, suggesting that, during either simple or ladder locomotion, they represent the cycling somatosensory events in their activity both predictively before and reflectively after these events take place
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Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers.
Although promoter-associated CpG islands have been established as targets of DNA methylation changes in cancer, previous studies suggest that epigenetic dysregulation outside the promoter region may be more closely associated with transcriptional changes. Here we examine DNA methylation, chromatin marks, and transcriptional alterations to define the relationship between transcriptional modulation and spatial changes in chromatin structure. Using human papillomavirus-related oropharyngeal carcinoma as a model, we show aberrant enrichment of repressive H3K9me3 at the transcriptional start site (TSS) with methylation-associated, tumor-specific gene silencing. Further analysis identifies a hypermethylated subtype which shows a functional convergence on MYC targets and association with CREBBP/EP300 mutation. The tumor-specific shift to transcriptional repression associated with DNA methylation at TSSs was confirmed in multiple tumor types. Our data may show a common underlying epigenetic dysregulation in cancer associated with broad enrichment of repressive chromatin marks and aberrant DNA hypermethylation at TSSs in combination with MYC network activation
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