434 research outputs found
On the indistinguishability of Raman photons
We provide a theoretical framework to study the effect of dephasing on the
quantum indistinguishability of single photons emitted from a coherently driven
cavity QED -system. We show that with a large excited-state detuning,
the photon indistinguishability can be drastically improved provided that the
fluctuation rate of the noise source affecting the excited state is fast
compared with the photon emission rate. In some cases a spectral filter is
required to realize this improvement, but the cost in efficiency can be made
small.Comment: 18 pages, 3 figures, final versio
Protection against Clostridium difficile infection in a hamster model by oral vaccination using flagellin FliC-loaded pectin beads
International audienceClostridium difficile flagellin FliC is a highly immunogenic pathogen-associated molecular pattern playing a key role in C. difficile pathogenesis and gut colonization. Here, we designed an oral vaccine against C. difficile with FliC encapsulated into pectin beads for colonic release. Bead stability and FliC retention was confirmed in vitro using simulated intestinal media (SIM), while bead degradation and FliC release was observed upon incubation in simulated colonic media (SCM). The importance of FliC encapsulation into pectin beads for protection against C. difficile was assessed in a vaccination assay using a lethal ham-ster model of C. difficile infection. Three groups of hamsters orally received either FliC-loaded beads or unloaded beads in gastro-resistant capsule to limit gastric degradation or free FliC. Two other groups were immunized with free FliC, one intra-rectally and the other intra-peritoneally. Hamsters were then challenged with a lethal dose of C. difficile VPI 10463. Fifty percent of hamsters orally immunized with FliC-loaded beads survived whereas all hamsters orally immunized with free FliC died within 7 days post challenge. No significant protection was observed in the other groups. Only intra-peritoneally immunized hamsters presented anti-FliC IgG antibodies in sera after immunizations. These results suggest that an oral immunization with FliC-loaded beads probably induced a mucosal immune response, therefore providing a protective effect. This study confirms the importance of FliC encapsulation into pectin beads for a protective oral vaccine against C. difficile
Photoluminescence of single colour defects in 50 nm diamond nanocrystals
We used optical confocal microscopy to study optical properties of diamond 50
nm nanocrystals first irradiated with an electron beam, then dispersed as a
colloidal solution and finally deposited on a silica slide. At room
temperature, under CW laser excitation at a wavelength of 514.5 nm we observed
perfectly photostable single Nitrogen-Vacancy (NV) colour defects embedded in
the nanocrystals. From the zero-phonon line around 575 nm in the spectrum of
emitted light, we infer a neutral NV0 type of defect. Such nanoparticle with
intrinsic fluorescence are highly promising for applications in biology where
long-term emitting fluorescent bio-compatible nanoprobes are still missing.Comment: proceedings of ICDS 23 conference (23rd International Conference on
Defects in Semiconductors, July 24 - July 29, 2005, Awaji Island, Hyogo,
Japan); to appear in "Physica B
Coupling Single NV Centers in Diamond to Optical Microcavities
Coupling of the NV^- ZPL to a silica microcavity and tapered fiber is demonstrated at cryogenic temperatures. Coupling to a high-Q cavity should enhance the usefulness of the NV^-for quantum information applications
Targeting gemcitabine containing liposomes to CD44 expressing pancreatic adenocarcinoma cells causes an increase in the antitumoral activity
Quality and Safety Aspects of Infant Nutrition
Quality and safety aspects of infant nutrition are of key importance for child health, but oftentimes they do not get much attention by health care professionals whose interest tends to focus on functional benefits of early nutrition. Unbalanced diets and harmful food components induce particularly high risks for untoward effects in infants because of their rapid growth, high nutrient needs, and their typical dependence on only one or few foods during the first months of life. The concepts, standards and practices that relate to infant food quality and safety were discussed at a scientific workshop organized by the Child Health Foundation and the Early Nutrition Academy jointly with the European Society for Paediatric Gastroenterology, Hepatology and Nutrition, and a summary is provided here. The participants reviewed past and current issues on quality and safety, the role of different stakeholders, and recommendations to avert future issues. It was concluded that a high level of quality and safety is currently achieved, but this is no reason for complacency. The food industry carries the primary responsibility for the safety and suitability of their products, including the quality of composition, raw materials and production processes. Introduction of new or modified products should be preceded by a thorough science based review of suitability and safety by an independent authority. Food safety events should be managed on an international basis. Global collaboration of food producers, food-safety authorities, paediatricians and scientists is needed to efficiently exchange information and to best protect public health. Copyright (C) 2012 S. Karger AG, Base
- …