Is There a Fundamental Right to Privacy When an Educational Institution Requires a Student to Disclose Proof of His or Her Vaccination Status?

In 2020, the coronavirus disease (“COVID-19”) dominated the world. Although the public has progressively become more informed about the disease and how to safeguard itself, challenges persist as there is still much unknown. Aside from wearing masks, social distancing, and despite its undetermined consequences, the COVID-19 vaccination has emerged as a primary solution to substantially reducing the incidence and severity of the virus in our country. Many COVID-19 vaccine mandates were initiated once three pharmaceutical and biotechnology companies including Pfizer-BioNTech, Moderna, and Johnson & Johnson received Emergency Use Authorization from the Food and Drug Administration (“FDA”)

Inhibition of nonsense-mediated mRNA decay by the cytoplasmic poly(A)-binding protein

The expression of a gene from transcription of the DNA into pre-messenger RNA (pre-mRNA) over translation of messenger RNA (mRNA) into protein is constantly monitored for errors. This quality control is necessary to guarantee successful gene expression. One quality control mechanism important to this thesis is called nonsense-mediated mRNA decay (NMD). NMD is a cellular process that eliminates mRNA transcripts harboring premature translation termination codons (PTCs). Furthermore, NMD is known to regulate certain transcripts with long 3′ UTRs. However, some mRNA transcripts are known to evade NMD. The mechanism of NMD activation has been subjected to many studies whereas NMD evasion or suppression still remains rather elusive. It has previously been shown that the cytoplasmic poly(A)-binding protein (PABPC1) is able to suppress NMD of certain transcripts. In this study I show that PABPC1 is able to suppress NMD of a long 3′ UTR-carrying reporter when tethered immediately downstream of the termination codon. I further am able to show the importance of the interaction between PABPC1 and eIF4G for NMD suppression, whereas the interaction between PABPC1 and eRF3a seems dispensable. These results indicate an involvement of efficient translation termination and potentially ribosome recycling in NMD suppression. I am able to show that if PABPC1 is too far removed from the terminating ribosome NMD is activated. After showing the importance of PABPC1 recruitment directly downstream of a terminating ribosome in NMD suppression, I am further able to demonstrate several different methods by which PABPC1 can be recruited. Fold-back of the poly(A)-tail mediated by two interacting proteins on opposite ends of a 3′ UTR manages to bring PABPC1 bound to the poly(A)-tail into close proximity of the terminating ribosome and therefore suppress NMD. Furthermore, small PAM2 peptides that are known to interact with the MLLE domain of PABPC1 are able to strongly suppress NMD initiated by either a long 3′ UTR or an EJC. I am also able to show the NMD antagonizing power of recruited PABPC1 for the known endogenous NMD target β-globin PTC39, which is responsible for the disease β-thalassemia. This shows the potential medical implications and application of suppressing NMD by recruiting PABPC1 into close proximity of a terminating ribosome

The Ursinus Weekly, April 10, 1961

Morita represents Ursinus at Peace Corps conference • Cressman, Nelson vie for YWCA prexy post • Dr. McClure\u27s portrait on exhibit in Library • Dr. Gilmer speaks to psych forum tonight in Pfahler • MSGA warns campus cut-ups; Pranks cause local discontent: Sandercock discusses townsfolk\u27s complaints; Activities Committee donates rec room funds • Ferrell, Sheese head slate of WAA officers • Four co-eds seek office as WSGA president • Five IRC members join in Model UN Assembly • Editorial: What the Weekly says • Ursinus in the past • From Bach to Dixie • Letters to the editor • Chapel commentary • Badminton girls undefeated sixth consecutive year • Winning season first for Mermaids since 1955 swimmers • Siebmen succumb; Drop two games • Morgan, Sermarini set field marks in losing cinder cause Wednesday • Brammal conducts tennis clinic here • European seminar has two openings • Spanish Club film tomorrow night • IIE lists Summer study openings • Sandberg recipient of two scholarships • Valley Forge band plays at Norristown concert • Alohahttps://digitalcommons.ursinus.edu/weekly/1338/thumbnail.jp

The Ursinus Weekly, April 10, 1961

Morita represents Ursinus at Peace Corps conference • Cressman, Nelson vie for YWCA prexy post • Dr. McClure\u27s portrait on exhibit in Library • Dr. Gilmer speaks to psych forum tonight in Pfahler • MSGA warns campus cut-ups; Pranks cause local discontent: Sandercock discusses townsfolk\u27s complaints; Activities Committee donates rec room funds • Ferrell, Sheese head slate of WAA officers • Four co-eds seek office as WSGA president • Five IRC members join in Model UN Assembly • Editorial: What the Weekly says • Ursinus in the past • From Bach to Dixie • Letters to the editor • Chapel commentary • Badminton girls undefeated sixth consecutive year • Winning season first for Mermaids since 1955 swimmers • Siebmen succumb; Drop two games • Morgan, Sermarini set field marks in losing cinder cause Wednesday • Brammal conducts tennis clinic here • European seminar has two openings • Spanish Club film tomorrow night • IIE lists Summer study openings • Sandberg recipient of two scholarships • Valley Forge band plays at Norristown concert • Alohahttps://digitalcommons.ursinus.edu/weekly/1338/thumbnail.jp

Le rôle du pharmacien d'officine dans la prise en charge du cancer du sein

Le cancer du sein représente plus de 31% de tous les cancers chaque année, avec 50.000 nouveaux cas et environ 10.000 morts. À l'heure actuelle, différents facteurs de risque sont avérés (génétiques, environnementaux, âge et sexe, hormonaux, hygiénodiététiques) et permettent tout comme le dépistage organisé un diagnostic plus précoce ce qui augmente les chances de guérison. La prise en charge thérapeutique est basée sur 4 grands axes : chirurgie, chimiothérapie, radiothérapie et hormonothérapie responsables de nombreux effets indésirables. Le suivi de la maladie par un professionnel de santé tel que le pharmacien d'officine devient essentiel notamment pour une meilleure gestion des effets indésirables. Celui-ci aura également un rôle d'écoute, d'accompagnement et de conseils auprès de la patiente tout au long de sa maladie. Il se devra de pouvoir répondre à certaines interrogations de sa patiente, notamment sur le dépistage, le diagnostic et la prise en charge. Lors de la délivrance des divers médicaments, le pharmacien pourra prodiguer à la patiente quelques conseils alimentaires, lui remettre des fiches destinées aux patients sur les chimiothérapies orales. Enfin, le pharmacien pourra être amené à prendre les mesures pour la délivrance de prothèses mammaires, de manchon. Le pharmacien d'officine à une place importante dans la prise en charge pluridisciplinaire du cancer du sein

In Vivo und in Vitro Untersuchungen an der isolierten Translationsinitationsregion des Genes 0,3 des Bakteriophagen T7

SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Is There a Fundamental Right to Privacy When an Educational Institution Requires a Student to Disclose Proof of His or Her Vaccination Status?

In 2020, the coronavirus disease (“COVID-19”) dominated the world. Although the public has progressively become more informed about the disease and how to safeguard itself, challenges persist as there is still much unknown. Aside from wearing masks, social distancing, and despite its undetermined consequences, the COVID-19 vaccination has emerged as a primary solution to substantially reducing the incidence and severity of the virus in our country. Many COVID-19 vaccine mandates were initiated once three pharmaceutical and biotechnology companies including Pfizer-BioNTech, Moderna, and Johnson & Johnson received Emergency Use Authorization from the Food and Drug Administration (“FDA”)

Les limitations et arrêts de thérapeutique(s) active(s) en médecine préhospitalière

Les limitations et arrêts des thérapeutiques actives sont une pratique répandue dans les services hospitaliers de réanimation et d'urgence. Elles sont régies par des recommandations de la SRLF et de la SFMU. En 2005 est votée la loi Leonetti qui apporte des précisions quant à la prise de décision des LATA et à leurs conditions d'applications. En médecine préhospitalière qui apparaît comme un lieu particulier d'exercice de la médecine d'urgence, ces règles sont systématiquement mises à mal, notamment en terme de collégialité. Une étude est menée au SAMU-SMUR du CHU de Nantes, répertoriant toutes les LATA décidées lors d'interventions du SMUR du 1er avril 2009 au 15 août 2009. Les résultats montrent que les LATA intéressent une population âgée, peu autonome, aux multiples comorbidités. On s'interroge sur la collégialité de la décision telle qu'elle est décrite dans les textes, sur la problématique de la traçabilité et sur la mise en place de soins palliatifs en préhospitalier.NANTES-BU Médecine pharmacie (441092101) / SudocSudocFranceF