Royal jelly accelerates healing of acetate induced gastric ulcers in male rats

Aim: This study examined the healing potential of royal jelly on the acetic acid induced wounds healing in male rat’s gastric mucosa. Background: Scientific reports suggest that, bee products can help in the wounds healing. Methods: 96 adult male Wistar rats were divided into in 4 groups as follows: control, omeprazole 20 mg/kg, and royal jelly 50 and 200 mg/kg). Wound was induced in stomach mucosa of each rat with 100% acetic acid. Samples groups received omeprazole or royal jelly from 1st to 14th day after acetic ulcer induction. Gastric ulcer healing and histopathological parameters were evaluated on 4, 7, 10, 15th days after ulceration. Both descriptive and statistical analyses were used. P <0.05 was considered as significant. Results: The royal jelly administration significantly reduced the depth of lesion in comparison with the control group (p<0.05) and attuned histopathological changes in the treatment groups. The largest healing effect was demonstrated with royal jelly on 10th treatment day, at a higher concentration (200 mg/kg). Conclusion: These findings supported that royal jelly had effectively contributed to the wound healing, valid gastroprotective activity, and can be used for peptic ulcer therapy

Royal jelly accelerates healing of acetate induced gastric ulcers in male Rats

Aim: This study examined the healing potential of royal jelly on the acetic acid induced wounds healing in male rat’s gastric mucosa. Background: Scientific reports suggest that, bee products can help in the wounds healing. Methods: 96 adult male Wistar rats were divided into in 4 groups as follows: control, omeprazole 20 mg/kg, and royal jelly 50 and 200 mg/kg). Wound was induced in stomach mucosa of each rat with 100% acetic acid. Samples groups received omeprazole or royal jelly from 1st to 14th day after acetic ulcer induction. Gastric ulcer healing and histopathological parameters were evaluated on 4, 7, 10, 15th days after ulceration. Both descriptive and statistical analyses were used. P <0.05 was considered as significant. Results: The royal jelly administration significantly reduced the depth of lesion in comparison with the control group (p<0.05) and attuned histopathological changes in the treatment groups. The largest healing effect was demonstrated with royal jelly on 10th treatment day, at a higher concentration (200 mg/kg). Conclusion: These findings supported that royal jelly had effectively contributed to the wound healing, valid gastroprotective activity, and can be used for peptic ulcer therapy. Keywords: Royal jelly, Gastric ulcer, Ra

Reliability and validity of the Oxford happiness inventory among university students in Iran

The aim of the present study was to examine the internal reliability, content validity, construct validity, and concurrent validity of the Persian translation/Farsi version of the Oxford Happiness Inventory. The Oxford Happiness Inventory and Fordyce Happiness Inventory were completed by a sample of 727 Iranian university students. Findings confirmed the internal reliability, construct, and concurrent validity of the Oxford Happiness Inventory. Thus, it can be recommended for use as a trait-measure of happiness among Iranian samples.El objetivo de este estudio fue examinar la fiabilidad internal, la validez de contenido, la validez de constructo y la validez concurrente de la traducción persa/varsión farsi del Inventario de Felicidad de Oxford (Oxford Happiness Inventory). Una muestra de 727 estudiantes universitarios iraníes completaron el Inventario de Felicidad de Oxford y al Inventario de Felicidad de Fordyce. Los resultados confirmaron la fiabilidad interna, la validez de constructo y la validez concurrente del Inventario de Felicidad de Oxford. Así, puede ser recomendarse para su uso como medida de rasgo de felicidad en muestras iraníes

The prevalence and related factors of low birth weight

Background and aims:The most common reason in neonatal mortality rate in the world is low birth weight (LBW). The objective of our study was to determine the prevalence and related factors associated in birth weight in Garmsar, Iran in 2013. Methods: This cross sectional study was carried out on 683 live births which delivered in Garmsar in 2013. The required information was collected by examining the health records of pregnant women and completion of the data registration forms. Data collection was controlled by using SPSSand analyzed by using an Independent T-test, Chi-square test and logistic regression. Results: According to the results, 32 infants out of 683 infants born in 2013 had low birth weight, i.e. the weight less than 2500g. LBW prevalence estimated in this study was 4.7. There were significant statistical relations between low birth weight and the variables including number of births, mothers’ occupation and interval of less than 3 years between pregnancies and systolic and diastolic blood pressures. Conclusion: Although our results regarding LBW prevalence and risk factors confirm the results of other studies,it was recommended perspective studies to reconfirm the LBW risk factors

Primary Ovarian Ectopic Pregnancy: A Case Report

Introduction: Ectopic pregnancy is a serious health problem that leads to maternal mortality and morbidity. The current article was based on the record of a female patient with primary ovarian ectopic pregnancy. Case Presentation: The patient was a 28-year-old female with regular previous menstrual cycle and without using any contraception method. She presented with right lower abdominal pain and amenorrhea. Transvaginal sonography findings revealed a gestational sac in the right ovary. Finally, primary ovarian ectopic pregnancy was diagnosed by laparotomy and confirmed by histopathology. Conclusions: To prevent misdiagnosis, an awareness of this issue should be developed by gynecologists, surgeons, and radiologists. Keywords: Ovary, Ectopic Pregnanc

Physicochemical and antibacterial assessment of Iranian Propolis

ABSTRACT Background: Propolis is one of the useful bee colony products that have been used in traditional medicine for centuries. In this study, the physicochemical characters and their antibacterial effect of Iranian Propolis collected from Qazvin province was assessed. Methods: In this study, Thin Layer Chromatography and Vacuum Liquid Chromatography to detect different compounds of the extract have been used. In the initial evaluation of Propolis extract, it was found that the extract includes variable compounds with different polarity. Therefore, the initial classification of extract with different polarity solvents was essential. Finally, 0.1 gr hydro alcoholic Propolis was injected to the HPLC by ultrasound. The antibacterial effect of Iranian ethanol extract Propolis was measured using a microdilution method against Pseudomonas aeruginosa: P. aeruginosa and Staphylococcus aureus: S.aureus standard strains and the minimum bactericidal and inhibitory concentration were defined. Results: Primary analysis of the ethanol extract by analytical Thin Layer Chromatography, demonstrated the presence of flavonoid and phenol in it. minimum inhibitory concentration and minimum bactericidal concentration for Staphylococcus aureus: S.aureus standard strain was 2.5mg/ml. The same procedure was done for Pseudomonas aeruginosa: P. aeruginosa standard strain and the minimum inhibitory concentration and minimum bactericidal concentration were 50mg/ml of Propolis extracts. Conclusion: According to the results, the alcoholic extract of propolis from Qazvin province of Iran provides significant antimicrobial activity. Its powerful activity may be due to high total phenolic and flavonoid contents

The Effect of Oral Consumption of Propolis Alone and in Combination With Silver Nanoparticles on Wound Healing in Male Wistar Rats

Research to identify and develop compounds that facilitate wound healing is important, especially for hard-to-heal chronic wounds. PURPOSE: This study was conducted to investigate the effects of orally administered propolis (a resinous substance found in beehives), alone and in combination with silver nanoparticles (SNPs), on the wound healing process in male rats. METHODS: Forty (40) male Wistar rats were randomly divided into 4 groups of 10 each: 1 control group received no treatment, and 3 study groups received a daily dose of 1) propolis (100 mg/kg), 2) propolis + 30 ppm SNPs, or 3) propolis + 60 ppm SNPs. Healing rate was determined by wound surface area reduction on days 4, 6, 8, and 10 post-surgery. On day 12 after wound creation, histological changes of wound healing, including number of new vessels, inflammatory cells (neutrophils, eosinophils, and mast cells), and fibroblasts, were counted based on morphology using a 400x objective lens, and collagen deposition density was determined using hematoxylin and eosin and trichrome staining, respectively. The histological scores were based on a 0 to 4 scale from lowest to highest amount of improving tissue status and were analyzed using one-way analysis of variance, Tukey test, Kruskal-Wallis test, t test, and Mann-Whitney U test to examine differences among the groups. Significance was set at P <.05. RESULTS: The rate of wound healing was significantly different between the control and the treated groups on days 4, 6, 8, and 10 (percent change was not assessed on day 12) post-surgery, especially in the propolis + 30 ppm SNPs group compared to the control group. This difference was more significant on days 6 (wound healing percentage [WHP]: 75% and 45%) and 8 (WHP: 88% and 65% ) post-surgery (P <.001). Mean neutrophil count on day 12 was highest in the control (34.8 ± 2.97) and lowest in the propolis + 30 ppm SNPs group (16.55 ± 2.12). The number of eosinophils on day 12 was considerably higher in the control group (1.05 ± 4) compared to those in the propolis group (3 ± 0.70), propolis + 30 ppm SNPs group (60/0 ± 1/1), and propolis + 60 ppm SNPs group (0.5 ± 0.52) (P <.001). Mean propolis + 30 ppm SNPs scores for epithelialization and granulation tissue formation were 3 and 4, respectively; in the propolis + 60 ppm SNPs, scores were 2 and 3, respectively; in the propolis alone group scores were 2 and 3, respectively (statistical significance not computed for semiquantitative values). The highest fibroblast count was in the propolis + 30 ppm SNPs group (114.44 ± 3.90) compared to control group (73.2 ± 2.8); P <.001). The difference in collagen fiber density scores was also significant: 1.2 ± 0.42 in the control and 3.66 ± 0.50 in the propolis + 30 ppm SNPs group; (P <.001). The mean of collagen fiber density in the propolis + 60 ppm SNPs group was 2.63 ± 0.51. CONCLUSION: Oral propolis alone and in combination with 30 ppm SNPs appears to provide anti-inflammatory effects and increase fibroblast proliferation and collagen deposition in experimental wounds, which may explain the observed differences in healing. Propolis + 60 ppm SNPs appears to have a cytotoxic effect. Research confirming these results and that examines toxicity levels in animals and humans is needed

PIN1 as a Predictive Biomarker for H. pylori Infection–Associated Gastric Cancer

Cancer is now one of the major causes of death across the globe. Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1), has recently emerged as a critical factor in various cancers. Numerous studies have shown that PIN1 is highly expressed in several cancer types and is significantly associated with the prognosis of patients with a certain type of tumor such as gastric cancer. Meanwhile, some studies have indicated that infection with Helicobacter pylori significantly increases the risk of developing duodenal and gastric ulcer disease and gastric cancer. In this article, we propose that PIN1 can play a vital role in the prognosis of Helicobacter pylori infection-associated with peptic ulcer disease and can be effective in order to provide the best cure and the choice for treatment