Study of relationship between serum vitamin D level and IgE in allergic children

زمینه و هدف: در سال های اخیر، نقش کمبود ویتامین D در بروز و تشدید انواع آلرژی مورد توجه قرار گرفته و مطالعاتی در این زمینه انجام شده است. از آنجاییکه کمبود ویتامین D و نیز شیوع آلرژی از مسائل مهم حوزه سلامت است، هدف این مطالعه بررسی ارتباط سطح سرمی ویتامین D و IgE کودکان مبتلا به آلرژی نوع یک در شهر تهران می باشد. روش بررسی: در یک مطالعه مقطعی، 112 کودک زیر 12 سال آلرژیک (48 دختر و 64 پسر) در شهر تهران بررسی شدند. سطح سرمی ویتامین D و IgE تام با روش الایزا تعیین شد. ویتامین D در 3 سطح کمبود (20> نانوگرم بر میلی لیتر)، ناکافی (30-20 نانوگرم بر میلی لیتر) و کافی (30< نانوگرم بر میلی لیتر) طبقه بندی شد. جهت تأیید IgE اختصاصی از تست پوستی پریک استفاده شد. سپس داده ها توسط نرم افزار SPSS آنالیز شد. یافته‌ها: میانگین سطح ویتامین D 64/17±14/27 نانوگرم بر میلی لیتر بود که در محدوده ناکافی قرار می گیرد. 4/38 افراد دارای ویتامین D طبیعی و 9/61 غیر طبیعی (5/20 ناکافی و 4/41 کمبود) بودند. کمبود ویتامین D با جنسیت دختر ارتباط داشت (03/0=P). اگرچه کمبود ویتامین D با افزایش سن افزایش می یافت اما میانگین آن بین گروه های سنی اختلاف معنی داری نداشت. هرچند در 8/43 سطح IgE تام بالاتر از سطح طبیعی بود اما بین سطح ویتامین D و IgE ارتباطی وجود نداشت. نتیجه گیری: با توجه به شیوع ویتامین D غیر طبیعی در کودکان و تأثیر آن در بروز بیماری های آلرژیک، طراحی پروژه ملی و بررسی میزان نقص ویتامین D و ریسک فاکتورهای مرتبط با آن در کشور و آزمایشات غربالگری لازم به نظر می رسد

Investigation of Socio-Economic and Environmental Effects of Taleghan Dam Using Structural Equation Modeling

Today water supply issue in large cities seems to be a big problem. This becomes more important with population growth and urbanization extension. To cope with this problem lots of irrigation and drainage projects have been implemented and operated that subsequently many socio- economic and cultural effects have been brought to the areas . The objective of the present study is to survey the socio - economic and environmental effects of Taleghan dam to compare the two periods before and after the dam construction. The needed data have been gathered by use of a questionnaire and by interviewing 400 samples in the irrigation and drainage network’s region of Taleghan Dam, and encoded questions and outcome data have been analyzed in spss and lisrel software. The results showed an economic development in the region, but some factors like, lack of trust, lack of economic advantages and deficiency of facilities, decrease villagers’ willingness to invest. 63.3% of region’s environmental pollution has been increased mainly by the tourists. Not only is there no increase in Water sources but also they have been decreased. 98% of individuals declared that the people were not questioned in construction projects. About the coefficient of dam’s effect on region’s socio- economic and environmental development, the villagers have declared that the dam construction had no positive effect on region’s development

Investigation of Socio-Economic and Environmental Effects of Taleghan Dam Using Structural Equation Modeling

Today water supply issue in large cities seems to be a big problem. This becomes more important with population growth and urbanization extension. To cope with this problem lots of irrigation and drainage projects have been implemented and operated that subsequently many socio- economic and cultural effects have been brought to the areas . The objective of the present study is to survey the socio - economic and environmental effects of Taleghan dam to compare the two periods before and after the dam construction. The needed data have been gathered by use of a questionnaire and by interviewing 400 samples in the irrigation and drainage network’s region of Taleghan Dam, and encoded questions and outcome data have been analyzed in spss and lisrel software. The results showed an economic development in the region, but some factors like, lack of trust, lack of economic advantages and deficiency of facilities, decrease villagers’ willingness to invest. 63.3% of region’s environmental pollution has been increased mainly by the tourists. Not only is there no increase in Water sources but also they have been decreased. 98% of individuals declared that the people were not questioned in construction projects. About the coefficient of dam’s effect on region’s socio- economic and environmental development, the villagers have declared that the dam construction had no positive effect on region’s development

Investigation of Socio-Economic and Environmental Effects of Taleghan Dam Using Structural Equation Modeling International Journal of Agricultural Management and Development (IJAMAD)

T oday water supply issue in large cities seems to be a big problem. This becomes more important with population growth and urbanization extension. To cope with this problem lots of irrigation and drainage projects have been implemented and operated that subsequently many socio-economic and cultural effects have been brought to the areas . The objective of the present study is to survey the socio -economic and environmental effects of Taleghan dam to compare the two periods before and after the dam construction. The needed data have been gathered by use of a questionnaire and by interviewing 400 samples in the irrigation and drainage network's region of Taleghan Dam, and encoded questions and outcome data have been analyzed in spss and lisrel software. The results showed an economic development in the region, but some factors like, lack of trust, lack of economic advantages and deficiency of facilities, decrease villagers' willingness to invest. 63.3% of region's environmental pollution has been increased mainly by the tourists. Not only is there no increase in Water sources but also they have been decreased. 98% of individuals declared that the people were not questioned in construction projects. About the coefficient of dam's effect on region's socio-economic and environmental development, the villagers have declared that the dam construction had no positive effect on region's development. International Journal of Agricultural Management and Development (IJAMAD

Rebound Effects of Improved Energy Efficiency in Energy Intensive Industries: An Intertemporal Dynamic General Equilibrium Model

Energy-intensive industries in Iran are responsible for a significant share of energy consumption, especially oil products. Therefore, there is a major focus on promoting energy efficiency in such industries. Energy efficiency improvement results in rebound and backfire effects. In this paper we estimate the effects of fuel oil efficiency improvement in energy intensive industries based on intertemporal general equilibrium model. Simulation for long run period is done for two scenarios, including 3.1% efficiency improvement in energy intensive industries and all sectors of economy. Results show that the rebound effects in chemical industry, food and beverage, basic metal, paper, Rubber and plastic, non- metallic minerals, and wood industries leads to rebound effects in the first scenario. In the long-run, backfire effects are seen in the second scenario in which efficiency improvements for all sectors is considered. In addition, efficiency improvement will result in production cost decrease. Chemical and non- metallic mineral industries experiencing the most decreases of production cost around 1.1% and 0.7%, respectively

The correlation of long non-coding RNAs IFNG-AS1 and ZEB2-AS1 with IFN-γ and ZEB-2 expression in PBMCs and clinical features of patients with coronary artery disease

Background Aberrant expression of long non-coding RNAs (lncRNAs) can contribute to the pathogenesis of coronary artery disease (CAD). In this study, we aimed to evaluate the expression of lncRNA interferon gamma-antisense 1 (IFNG-AS1), zinc finger E-box binding homeobox 2 antisense RNA 1 (ZEB2-AS1), and their direct target genes (IFN-gamma and ZEB2, respectively) in peripheral blood mononuclear cell (PBMC) from CAD and healthy individuals. Methods and results We recruited 40 CAD patients and 40 healthy individuals. After doing some bioinformatics analyses, the expressions of IFNG-AS1/ ZEB2-AS1 lncRNAs and IFN-gamma/ ZEB2 in PBMCs were measured using quantitative real-time PCR. The possible correlation between the putative lncRNAs and disease severity was also assessed. Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive role of lncRNAs as diagnostic biomarkers in CAD patients. The expressions of IFNG-AS1 lncRNA as well as IFN-gamma and ZEB2 genes were significantly reduced in CAD patients compared to healthy subjects. In contrast, the expression of ZEB2-AS1 was up-regulated in these patients. Linear regression analysis unveiled that there is a positive correlation between the expression of IFNG-AS1 and IFN-gamma, also similarly, ZEB2-AS1 and ZEB2 in PBMCs of subjects. Moreover, the expression of IFNG-AS1 and ZEB2-AS1 correlated with the Gensini score. The area under the ROC curves ranged from 0.633-0.742 for ZEB2-AS1/ZEB2 and IFNG-AS1/IFN-gamma, respectively. Conclusions Our results indicated that the dysregulation of IFNG-AS1/IFN-gamma and ZEB2-AS1/ZEB2 in PBMCs of CAD patients may be involved in CAD pathogenesis