3 research outputs found
Evaluating the effects of air disinfectants in decontamination of COVIDâ19 aerosols
Abstract Introduction Airborne transmission is the most âŻcrucial mode of COVIDâ19 transmission. Therefore, disinfecting the severe acute respiratory syndrome coronavirusâ2 (SARSâCoVâ2) aerosols float can have important implications in limiting COVIDâ19 transmission. Herein, we aimed to review the studies that utilized various disinfectants to decontaminate and inactivate the SARSâCoVâ2 aerosols. Methods This study was a review that studied related articles published between December 1, 2019 and August 23, 2022. We searched the online databases of PubMed, Scopus, Web of Science, Cochrane, on August 23, 2021. The studies were downloaded into the EndNote software, duplicates were removed, and then the studies were screened based on the inclusion/exclusion criteria. The screening process involved two steps; first, the studies were screened based on their title and abstract and then their full texts. The included studies were used for the qualitative analysis. Results From 664 retrieved records, only 31 met the inclusion criteria and were included in the final qualitative analysis. Various materials like Ozone, H2O2, alcohol, and TiO2 and methods like heating and using Ultraviolet were described in these studies to disinfect places contaminated by COVIDâ19. It appeared that the efficacy of these disinfectants varies considerably depending on the situation, time, and ultimately their mode of application. Conclusion Following reliable protocols in combination with the proper selection of disinfectant agents for each purpose would serve to achieve desired elimination of the SARSâCoVâ2 transmission
The relationship between Câreactive protein and levels of various cytokines in patients with COVIDâ19: A systematic review and correlation analysis
Abstract Introduction Câreactive protein (CRP) and cytokines levels could alter in patients with coronavirus disease (COVIDâ19) due to the inflammatory response caused by the virus. This analysis aimed to assess the relationship between the CRP levels and the levels of various cytokines in COVIDâ19 patients. Materials and Methods We searched the databases of PubMed, Cochrane, and Web of Science for relevant articles on May 29th, 2021. Applying the inclusion/exclusion criteria, the retrieved records underwent twoâphase screenings; first, a title/abstract screening process, and then, a fullâtext screening to find the eligible studies. Data for study variables were extracted, including the CRP levels and the levels of all reported cytokines. A strong and significant relationship between Interleukins and CRP was defined as: pââ€â0.05, 0.7ââ€ârââ€â1. Results In this study, 103 studies were included for systematic review and correlation analysis. The aggregate mean and SD of study variables were calculated and reported. The correlation between Interleukins and CRP was measured using correlation coefficient (r). It appeared that interleukin (IL)â10 has a moderate and significant relationship with CRP (pââ€â0.05, râ=â0.472). ILâ10 predicted almost 10% of CRP changes. Conclusion This correlation analysis suggests ILâ10 is moderately correlated with CRP levels in patients with COVIDâ19 infection. A better understanding of the proâinflammatory markers could contribute to the implementation of therapeutic and preventive approaches. More prospective studies are suggested to explore the relationship between CRP and cytokines as potential markers for the early identification of COVIDâ19 progression and severity
The relationship between COVIDâ19 viral load and disease severity: A systematic review
International audiencePatients with COVID-19 may present different viral loads levels. However, the relationship between viral load and disease severity in COVID-19 is still unknown. Therefore, this study aimed to systematically review the association between SARS-CoV-2 viral load and COVID-19 severity