Nutritive Value of Double Cropped Corn for Ruminant Production

The viability of double cropping corn (Zea mays L.) in Uruguay, germplasm combination, dry matter yield and nutritive value were evaluated. An early (E) maturing hybrid, an early to medium (E-M) one and an E-M variety were planted as spring crops. One E-M hybrid, one medium to late (M-L) hybrid and a late (L) variety were planted as a second crop. PVC laboratory scale silo of the spring crop and the whole plant of the summer crop were chemically analyzed. The nutritive value of the silages were related to plant maturity stage. No differences were detected in nutritive value among cultivars in the second crop except for NDF. In the spring crop the higher DM/ha yield were obtained with the E-M hybrids and in the summer crop with the L variety. The effect of the previous crop was detected in those cultivars planted on the same field plot where the higher grain yield cultivars were obtained as spring crop. The yield results of both crops were higher for the combination of E-M cultivars and lower for those combinations that included one E cultivar as spring crop. The metabolizable energy (ME) results tend to dilute the initial differences in DM /ha, since quality and quantity parameters tends to compensate each other, with few differences among all. Double cropping corn is a viable option for Uruguay being unavoidable the no till cultivation of the summer crop, and the use of E and E-M cultivars as spring and summer crops, respectively

Vitamin D: no efficacy without deficiency. What's new?

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SEeD for Change: The Systemic Event Design Project Applied to Terra Madre Salone del Gusto for the Development of Food Communities

In the contemporary era, food plays a key role in balancing environmental, social, and economic balances, not only due to its primary identity as a resource that nourishes living beings and the planet but also through the processes triggered by stakeholders who act at the internal local food systems. In the latter, an orientation towards sustainability is increasingly urgently required, capable of achieving a widespread creation of shared value. In this scenario, the International Slow Food Association operates, which also, through the Terra Madre Salone del Gusto initiative, coordinates communities and events located throughout the world on the theme of “good, clean and fair” food. This article aims to analyze, through the lens of the systemic approach, the interesting and multifaceted impacts of this event, as an opportunity to disseminate and contagion of ideas, attitudes, and behaviors around the themes of sustainability and biodiversity, but also as a moment of consolidation and creation of relationships between and within local food systems and local communities. The research project presented, entitled “SEeD for Change”, was coordinated by the University of Gastronomic Sciences of Pollenzo with the University of Turin and helped to focus on the actors, relationships and contexts that actually and virtually hosted the event: places in which through a common and shared language, change has been generated

A case of mandible Paget's disease of the bone treated with intravenous neridronate

Paget's disease of bone (PDB) is a focal disorder of osteoclasts, leading to chaotic bone remodelling, and it is characterized by the presence of focal areas of excessive bone formation alongside with areas of focal bone resorption. The typical radiographic feature is the cotton wool appearance. To date, bisphosphonates are the mainstay of the treatment. We hereby report the case of a young woman presenting with mandible PDB, with a relevant diagnostic delay and mistakenly treated for five years with chronic oral corticosteroids. After our evaluation, the patient received treatment with intravenous neridronate (an amino-bisphosphonate licensed in Italy for the treatment of this disease), with achievement of clinical remission

Insight into the WNT system and its drug related response.

The WNT signalling pathway is a complex system for transferring information for DNA expression from the cell surface receptors to cytoplasm and then to the nucleus. It is based on several proteins that work together as agonists and antagonists in order to maintain homeostasys and to promote anabolic processes. The WNT system acts on all cellular lines involved in bone resorption and formation. WNT pathway can mainly be triggered by two different signalling cascades. The first is well known and is the so-called WNT-beta catenin system (or the canonical pathway), the second is known as the non canonical WNT pathway. WNT proteins form a superfamily of secreted glycoproteins. The association with surface receptors, called Frizzled, that are members of the G protein-coupled receptors superfamily and co receptors like low-density lipoprotein receptor-related proteins 5 and 6 (LRP5/6) complete the WNT system. LRP5/6 show high affinity for WNT antagonists that modulate the activity of this pathway: DKK1 and sclerostin (SCL), that play a crucial role in modulating the WNT system. The WNT-pathway and in particular its antagonists SCL and DKK1 seems to play a key role in the regulation of bone remodeling during treatment with bone active agents such as bisphosphonates, but not only. Their effects become relevant especially in the course of long-term treatments

Radiological features of knee joint synovial chondromatosis

Synovial chondromatosis (SC) is a rare condition with a very variable clinical presentation, thus making the diagnosis not immediate. We report a case of massive primary SC of the knee, properly evaluated with X-rays, ultrasonography and magnetic resonance imaging and successfully treated with an arthroscopic approach

Instability of Quark Matter Core in a Compact Newborn Neutron Star With Moderately Strong Magnetic Field

It is explicitly shown that if phase transition occurs at the core of a newborn neutron star with moderately strong magnetic field strength, which populates only the electron's Landau levels, then in the $\beta$-equilibrium condition, the quark core is energetically much more unstable than the neutron matter of identical physical condition.Comment: Six pages REVTEX file, one .eps file (included

Different fracture risk profile in patients treated with anti-osteoporotic drugs in real-life

In this retrospective study, we intended to investigate the baseline fracture risk profile in patients who started treatment with different anti-osteoporotic medications. We analyzed retrospectively the fracture risk calculated with DeFRA, a validated FRAX derived tool, in women who started an anti-osteoporotic treatment from 2010 to 2017. We analyzed baseline data of 12,024 post-menopausal women aged over 50 years. Teriparatide initiators had a baseline 10-year risk of major osteoporotic fracture of 82.1% with a Standard Deviation (SD) of 66.5%. Denosumab initiators and zoledronic acid initiators had a greater 10-year baseline risk of fracture (54.3%, SD 46.5% and 47.0%, SD 42.0 respectively) than patients initiated on alendronate (24.9%, SD 34.6%) and patients initiated on risedronate (23.9%, SD 24.1%). Using DeFRA, a FRAX™ derived tool, we showed significantly different fracture risk profiles in women who were started on various therapeutic agents for the treatment of osteoporosis in routine clinical practice

Association between exposure to fine particulate matter and osteoporosis: a population-based cohort study

Long-term environmental air pollution exposure was associated with osteoporosis' risk in a cohort of women at high risk of fracture. Cortical sites seemed to be more susceptible to the exposure's effect