Innovation through the flipped model of learning: enriching students' and instructors' experience

The paper provides a brief literature review of the FML, a description of the FML experience within the context of a multi-year project in a major research university – from designing to producing and integrating it into the second-language writing curriculum – and recommendations for scalable implementation. Special attention is given to the benefits of this approach for students as well as to its broader pedagogical advantages.Published versio

Perception of tactile vibrations and a putative neuronal code

We devised a delayed comparison task, appropriate for human and rats, in which subjects discriminate between pairs of vibration delivered either to their whiskers, in rats, or fingertips, in humans, with a delay inserted between the two stimuli. Stimuli were composed of a random time series of velocity values (\u201cnoise\u201d) taken from a Gaussian distribution with 0 mean and standard deviation referred to as \u3c31 for the first stimulus and \u3c32 for the second stimulus. The subject must select a response depending on the two vibrations\u2019 relative standard deviations, \u3c31>\u3c32 or \u3c31<\u3c32. In the standard condition, the base and comparison stimuli both had duration of 400 ms and they were separated by a 800 ms pause. In this condition, humans had better performance than did rats on average, yet the best rats were better than the worst humans. To learn how signals are integrated over time, we varied the duration of the second stimulus. In rats, the performance was progressively improved when the comparison stimulus duration increased from 200 to 400 and then to 600 ms. In humans, the effect of comparison stimulus duration was different: an increase in duration did not improve their performance but biased their choice. Stimuli of longer duration were perceived as having a larger value of \u3c3. We employed a novel psychophysical reverse correlation method to find out which kinematic features of the stochastic stimulus influenced the choices of the subjects. This analysis revealed that rats rely principally on features related to velocity and speed values normalized by stimulus duration \u2013 that is, the rate of velocity and speed features per unit time. In contrast, while human subjects used velocity- and speed-related features, they tended to be influenced by the summated values of those features over time. The summation strategy in humans versus the rate strategy in rats accounts for both (i) the lack of improvement in humans for greater stimulus durations and (ii) the bias by which they judged longer stimuli as having a greater value of \u3c3. Next, we focused on the capacity of rats to accomplish a task of parametric working memory, a capacity until now not found in rodents. For delays between the base and comparison stimuli of up to 6-10 seconds, humans and rats showed similar performance. However when the difference in \u3c3 was small, the rats\u2019 performance began to decay over long inter-stimulus delays more markedly than did the humans\u2019 performance. The next chapter reports the analyses of the activity of barrel cortex neurons during the vibration comparison task. 35% of sampled neuron clusters showed a significant change in firing rate as \u3c3 varied, and the change was positive in every case \u2013 the slope of firing rate versus \u3c3 was positive. We used methods related to signal detection theory to estimate the behavioral performance that could be supported by single neuron clusters and found that the resulting \u201cneurometric\u201d curve was much less steep performance than the psychometric curve (the performance of the whole rat). This led to the notion that stimuli are encoded by larger populations. A general linear model (GLM) that combined multiple simultaneously recorded 2 clusters performed much better than single clusters and began to approach animal performance. We conclude that a potential code for the stimulus is the variation in firing rate according to \u3c3, distributed across large populations.In conclusion, this thesis characterizes the perceptual capacities of humans and rats in a novel working memory task. Both humans and rats can extract the statistical structure of a \u201cnoisy\u201d tactile vibration, but seem to integrate signals by different operations. A major finding is that rats are endowed with a capacity to hold stimulus parameters in working memory with a proficiency that, until now, could be ascribed only to primates. The statistical properties of the stimulus appear to be encoded by a distributed population

Intelligent Systemic/Systematic Innovation and Its Role in Delivering Improvement and Change in the Design of Mission Critical Systems

Mission critical systems (MCS) are complex nested hierarchies of systems, subsystems and components with defined purpose, characteristics, boundaries and interfaces, working in harmony to deliver vital organisational functionalities. Upgrading MCS performance is inevitable when capability enhancement is required or new technologies emerge. Improving MCS however is considered with certain degrees of reluctance due to their sensitive role in organisations and the potential disruptive impact of unexpected consequences of change. Innovation in MCS often appears in small steps that affect the entire system due to their highly interdependent structures. Effective management of innovation introduction in complex systems require systemic/systematic processes that involve process management and collective analysis, scoping, decision-making and R&D which relies on effective information sharing. This approach should run throughout the system and must include all aspects and stakeholders, utilising the skills and knowledge of all involved. This chapter describes the basic concepts and potential approaches that could be utilised to build intelligent systemic/systematic and collaborative environments for MCS innovation. Advances in ICT technologies provide an opportunity to access the wider sphere of knowledge and support the systemic innovation processes. Adopting systemic approaches increases process efficacy, leading to more reliable solutions, shorter development lead times and reduced costs

Psychometrics of the scale of attitudes toward physician-pharmacist collaboration: a study with medical students.

BACKGROUND: Despite the emphasis placed on interdisciplinary education and interprofessional collaboration between physicians and pharmacologists, no psychometrically sound instrument is available to measure attitudes toward collaborative relationships. AIM: This study was designed to examine psychometrics of an instrument for measuring attitudes toward physician-pharmacist collaborative relationships for administration to students in medical and pharmacy schools and to physicians and pharmacists. METHODS: The Scale of Attitudes Toward Physician-Pharmacist Collaboration was completed by 210 students at Jefferson Medical College. Factor analysis and correlational methods were used to examine psychometrics of the instrument. RESULTS: Consistent with the conceptual framework of interprofessional collaboration, three underlying constructs, namely responsibility and accountability; shared authority; and interdisciplinary education emerged from the factor analysis of the instrument providing support for its construct validity. The reliability coefficient alpha for the instrument was 0.90. The instrument\u27s criterion-related validity coefficient with scores of a validated instrument (Jefferson Scale of Attitudes Toward Physician-Nurse Collaboration) was 0.70. CONCLUSIONS: Findings provide support for the validity and reliability of the instrument for medical students. The instrument has the potential to be used for the evaluation of interdisciplinary education in medical and pharmacy schools, and for the evaluation of patient outcomes resulting from collaborative physician-pharmacist relationships

On the Relationship between the Implementation of Formative Assessment Strategies and Iranian EFL Teachers’ Self-Efficacy: Do Gender and Experience Make a Difference?*

This study sought to examine the relationship between the use of formative assessment strategies and the Iranian EFL teachers’ sense of self-efficacy. Moreover, this study investigated the relationships and interactions between the EFL teachers’ use of formative assessment strategies, their gender, level of experience, and sense of self-efficacy. This is a descriptive ex post facto design study which employed a three-part questionnaire, including demographic information, teachers’ formative assessment strategies, and teachers’ sense of self-efficacy. In order to collect data, sixty-one EFL teachers, including thirty-one female and thirty male participants who were selected through convenience sampling, completed the questionnaire. Multiple statistical strategies were employed to analyze the research questions of the study. The findings of Pearson’s and Spearman Rho correlation indicated that the EFL teachers’ use of formative assessment strategies was positively correlated with their sense of self-efficacy. However, the results of eta correlation coefficients revealed that there was no statistically significant relationship between the teachers’ implementation of formative assessment strategies and two other variables of gender and level of experience. Finally, the results of a three way factorial Analysis of Variance (ANOVA) evinced that there was no statistically significant interaction between the teachers’ use of formative assessment strategies, teachers’ sense of self-efficacy, their gender, and level of experience. Therefore, when the teachers become more aware of the ways to implement formative assessment strategies to inform instruction, their sense of self-efficacy can increase. This study has some implications in language testing, English pedagogy, and syllabus design and materials development

The further development, optimisation and application of a Yarn Dismantler

The fibre properties of cotton, which vary widely according to genetic and environmental conditions, determine its price and textile processing performance and product quality. It is therefore hardly surprising that cotton fibre properties are routinely measured for trading and quality control purposes, with a great deal of research having been, and still being, devoted towards developing instruments which enable the various fibre properties to be measured rapidly and accurately. In many cases, it is also necessary to be able to measure properties of cotton fibres when they have already been converted into yarn and fabric form. To do so, the yarn has to be dismantled into its component fibres, preferably without significantly changing the fibre properties. This could only be done by manually untwisting the yarn and carefully extracting the fibres from the untwisted yarn, care being taken not to break or lose any fibres in the process. This is a time consuming, laborious and labour intensive process. In view of this, a „yarn dismantler‟ which could automatically, cost effectively and within acceptable time frames, dismantle a cotton yarn into its constituent fibres, without undue damage or changes to the fibres, was developed and patented. This thesis reports the results of research undertaken to further develop, evaluate and optimize the yarn dismantler into the final prototype, as well as those relating to its practical applications, including tracking changes in fibre properties during miniature and pilot scale processing, up to, and including the yarn stage. Initial research undertaken on the original bench and first prototype models indicated that, although they produced very promising results, certain improvements and modifications were necessary, if the dismantler was to perform in an efficient and operator friendly manner at the required speeds. These included changes in the axial position of the untwisting spindle and the perforated screen of the suction drum, increasing the air suction at the perforated drum, installing a new motor for the untwisting spindle drive, separating the drives to the different parts of the unit in order to control them independently, integrating a more effective steaming unit into the unit etc. It was found that the dismantling rate had to be set to equal about 95 percent of the original twist in the yarn, and that steaming of the dismantled (untwisted) yarn on the perforated drum was necessary in order to eliminate any twist liveliness (residual torque) in the dismantled yarn, and enable it to be handled and tested on the AFIS instrument. When the final prototype Yarn Dismantler was produced, incorporating all the above mentioned improvements, it functioned very well at dismantling speeds of at least 2m/min, enabling the length of yarn required for subsequent AFIS testing to be dismantled within an acceptable time of less than 10 minutes, with excellent reproducibility and repeatability of results, also under commercial conditions. It was found that the AFIS measured length characteristics of fibres from the instrument dismantled yarns compared very well with those of fibres from manually dismantled yarns, differences in fibre length generally being less than 1mm, and it was concluded from these and other evaluation tests, that the yarn dismantler produced fibres without any significant fibre breakage. Some limited tests, carried out on commercially produced carded and combed yarns, indicated that short fibre content and dust and trash levels, as measured by the AFIS on fibres from dismantled yarn, together with the corresponding Uster Statistics, could enable a carded cotton yarn to be distinguished from a combed cotton yarn. Statistical analysis of fibre test results obtained at the different stages during miniature and pilot plant scale processing of various cottons, clearly showed that very significant changes in fibre properties could be caused by certain of the processes. For example, significant fibre breakage occurred during the drafting on the spinning frame, prior to twist insertion. The thesis provides detailed results of changes in various fibre properties, including length, short fibre content, maturity, immature fibre content, seed coat neps and fibrous neps, which occurred from the lint to the final yarn, as well as on the relationship between the properties of the fibres from the dismantled yarn and those from the lint. The results obtained have clearly demonstrated the practical value of the yarn dismantler in enabling yarns to be automatically dismantled into their constituent fibres, which can then be tested by an instrument, such as the AFIS, and the test results related to those of the original lint fibres, thereby opening up many fields of research and practical applications, some of which are captured under „Recommended Further Work‟

The further development, optimisation and application of a Yarn Dismantler

The fibre properties of cotton, which vary widely according to genetic and environmental conditions, determine its price and textile processing performance and product quality. It is therefore hardly surprising that cotton fibre properties are routinely measured for trading and quality control purposes, with a great deal of research having been, and still being, devoted towards developing instruments which enable the various fibre properties to be measured rapidly and accurately. In many cases, it is also necessary to be able to measure properties of cotton fibres when they have already been converted into yarn and fabric form. To do so, the yarn has to be dismantled into its component fibres, preferably without significantly changing the fibre properties. This could only be done by manually untwisting the yarn and carefully extracting the fibres from the untwisted yarn, care being taken not to break or lose any fibres in the process. This is a time consuming, laborious and labour intensive process. In view of this, a „yarn dismantler‟ which could automatically, cost effectively and within acceptable time frames, dismantle a cotton yarn into its constituent fibres, without undue damage or changes to the fibres, was developed and patented. This thesis reports the results of research undertaken to further develop, evaluate and optimize the yarn dismantler into the final prototype, as well as those relating to its practical applications, including tracking changes in fibre properties during miniature and pilot scale processing, up to, and including the yarn stage. Initial research undertaken on the original bench and first prototype models indicated that, although they produced very promising results, certain improvements and modifications were necessary, if the dismantler was to perform in an efficient and operator friendly manner at the required speeds. These included changes in the axial position of the untwisting spindle and the perforated screen of the suction drum, increasing the air suction at the perforated drum, installing a new motor for the untwisting spindle drive, separating the drives to the different parts of the unit in order to control them independently, integrating a more effective steaming unit into the unit etc. It was found that the dismantling rate had to be set to equal about 95 percent of the original twist in the yarn, and that steaming of the dismantled (untwisted) yarn on the perforated drum was necessary in order to eliminate any twist liveliness (residual torque) in the dismantled yarn, and enable it to be handled and tested on the AFIS instrument. When the final prototype Yarn Dismantler was produced, incorporating all the above mentioned improvements, it functioned very well at dismantling speeds of at least 2m/min, enabling the length of yarn required for subsequent AFIS testing to be dismantled within an acceptable time of less than 10 minutes, with excellent reproducibility and repeatability of results, also under commercial conditions. It was found that the AFIS measured length characteristics of fibres from the instrument dismantled yarns compared very well with those of fibres from manually dismantled yarns, differences in fibre length generally being less than 1mm, and it was concluded from these and other evaluation tests, that the yarn dismantler produced fibres without any significant fibre breakage. Some limited tests, carried out on commercially produced carded and combed yarns, indicated that short fibre content and dust and trash levels, as measured by the AFIS on fibres from dismantled yarn, together with the corresponding Uster Statistics, could enable a carded cotton yarn to be distinguished from a combed cotton yarn. Statistical analysis of fibre test results obtained at the different stages during miniature and pilot plant scale processing of various cottons, clearly showed that very significant changes in fibre properties could be caused by certain of the processes. For example, significant fibre breakage occurred during the drafting on the spinning frame, prior to twist insertion. The thesis provides detailed results of changes in various fibre properties, including length, short fibre content, maturity, immature fibre content, seed coat neps and fibrous neps, which occurred from the lint to the final yarn, as well as on the relationship between the properties of the fibres from the dismantled yarn and those from the lint. The results obtained have clearly demonstrated the practical value of the yarn dismantler in enabling yarns to be automatically dismantled into their constituent fibres, which can then be tested by an instrument, such as the AFIS, and the test results related to those of the original lint fibres, thereby opening up many fields of research and practical applications, some of which are captured under „Recommended Further Work‟

Transformation of perception from sensory to motor cortex

To better understand how a stream of sensory data is transformed into a percept, we examined neuronal activity in vibrissal sensory cortex, vS1, together with vibrissal motor cortex, vM1 (a frontal cortex target of vS1), while rats compared the intensity of two vibrations separated by an interstimulus delay. Vibrations were ‘‘noisy,’’ constructed by stringing together over time a sequence of velocity values sampled from a normal distribution; each vibration’s mean speed was proportional to the width of the normal distribution. Durations of both stimulus 1 and stimulus 2 could vary from 100 to 600 ms. Psychometric curves reveal that rats overestimated the longer-duration stimulus—thus, perceived intensity of a vibration grew over the course of hundreds of milliseconds even while the sensory input remained, on average, stationary. Human subjects demonstrated the identical perceptual phenomenon, indicating that the underlying mechanisms of temporal integration generalize across species. The time dependence of the percept allowed us to ask to what extent neurons encoded the ongoing stimulus stream versus the animal’s percept.We demonstrate that vS1 firing correlated with the local features of the vibration, whereas vM1 firing correlated with the percept: the final vM1 population state varied, as did the rat’s behavior, according to both stimulus speed and stimulus duration. Moreover, vM1 populations appeared to participate in the trace of the percept of stimulus 1 as the rat awaited stimulus 2. In conclusion, the transformation of sensory data into the percept appears to involve the integration and storage of vS1 signals by vM1

Xeroderma pigmentosum: overview of pharmacology and novel therapeutic strategies for neurological symptoms

Xeroderma Pigmentosum (XP) encompasses a group of rare diseases characterised in most cases by nucleotide excision repair (NER) malfunction, resulting in an increased sensitivity to ultraviolet radiation in affected individuals. Approximately 25-30% of XP patients present with neurological symptoms, such as sensorineural deafness, mental deterioration, and ataxia. Although it is known that dysfunctional DNA repair is the primary pathogenesis in XP, growing evidence suggests that mitochondrial pathophysiology may also occur. This appears to be secondary to dysfunctional NER but may contribute to the neurodegenerative process in these patients. The available pharmacological treatments in XP mostly target the dermal manifestations of the disease. In the present review, we outline how current understanding of the pathophysiology of XP could be used to develop novel therapies to counteract the neurological symptoms. Moreover, the coexistence of cancer and neurodegeneration present in XP, lead us to focus on possible new avenues targeting mitochondrial pathophysiology