'Two-speed' Scotland : patterns and implications of the digital divide in contemporary Scotland

Peer reviewedPublisher PD

Self-controlled case series with multiple event types

Self-controlled case series methods for events that may be classified as one of several types are described. When the event is non-recurrent, the different types correspond to competing risks. It is shown that, under circumstances that are likely to arise in practical applications, the SCCS multi-type likelihood reduces to the product of the type-specific likelihoods. For recurrent events, this applies whether or not the marginal type-specific counts are dependent. As for the standard SCCS method, a rare disease assumption is required for non-recurrent events. Several forms of this assumption are investigated by simulation. The methods are applied to data on MMR vaccine and convulsions (febrile and non-febrile), and to data on thiazolidinediones and fractures (at different sites)

Risk of myocardial infarction and stroke after acute infection or vaccination.

BACKGROUND: There is evidence that chronic inflammation may promote atherosclerotic disease. We tested the hypothesis that acute infection and vaccination increase the short-term risk of vascular events. METHODS: We undertook within-person comparisons, using the case-series method, to study the risks of myocardial infarction and stroke after common vaccinations and naturally occurring infections. The study was based on the United Kingdom General Practice Research Database, which contains computerized medical records of more than 5 million patients. RESULTS: A total of 20,486 persons with a first myocardial infarction and 19,063 persons with a first stroke who received influenza vaccine were included in the analysis. There was no increase in the risk of myocardial infarction or stroke in the period after influenza, tetanus, or pneumococcal vaccination. However, the risks of both events were substantially higher after a diagnosis of systemic respiratory tract infection and were highest during the first three days (incidence ratio for myocardial infarction, 4.95; 95 percent confidence interval, 4.43 to 5.53; incidence ratio for stroke, 3.19; 95 percent confidence interval, 2.81 to 3.62). The risks then gradually fell during the following weeks. The risks were raised significantly but to a lesser degree after a diagnosis of urinary tract infection. The findings for recurrent myocardial infarctions and stroke were similar to those for first events. CONCLUSIONS: Our findings provide support for the concept that acute infections are associated with a transient increase in the risk of vascular events. By contrast, influenza, tetanus, and pneumococcal vaccinations do not produce a detectable increase in the risk of vascular events

So you want to get published? It’s all about theory, context and data

This paper offers guidance on writing for publication in peer-reviewed business and management journals. The approach outlined and illustrated within is the amalgamated result of many years of experience in academic writing, editing, and getting published. The paper is primarily aimed at doctoral students, tutors, and early career researchers, who will have plenty to gain from publication, but may be lacking in the relevant experience of submission and resubmission. The authors assert the importance of creating dedicated planning documents, subject to continual revision, with particular emphasis placed on articulating and addressing gaps in theory, method, context, and management practice.Keywords: Theory, context, data, publishing, ga

A mathematical model, with cost implications, for predicting temperatures in seed stores (ODNRI Bulletin No. 16)

Mathematical relationships are derived between climatic and design factors in seed stores using heat balance equations modified for tropical seed storage. A computer program has been written for the Hewlett Packard 9645 to make calculation easy; this incorporates data banks of the required parameters for common store building materials and for typical tropical climates. This program has been partially verified for grain in Sri Lanka using field data. Results from program case studies highlight the relative importance of different elements of warehouse design. For seed stores, the program employs viability equations to provide least-cost combinations of warehouse cladding and seed drying regimes under varying conditions of climate and building design. In a typical 1,000-tonne seed store use of aluminium roofing and concrete block walls instead of corrugated steel cladding can save over £12,000 a year, if both drying costs and annualized building costs are taken into account