Ergonomic Immobilization Frame for Radiotherapy

The primary purpose of this project is to demonstrate that patients can be safely immobilized using air in the general torso area so that radiation can be administered to that region. The primary target will be to treat tumors in the lungs and liver. By immobilizing patients during treatment it allows for the radiation to be consistent in targeting the desired region of the body, which would not be the case if the patient was moving. Air was chosen as the desired medium to immobilize the patient because of comfort and it provides an easy medium for radiation to travel through which does not interfere with the radiation. Through research the limiting factor of human body was the pulmonary cycle which was determined to be approximately 0.15 Psi. In order to use air for immobilization airbags were incorporated as a means to hold the air and once pressurized would be used as the restraint force on the patient. As a means to demonstrate that air in fact could be used to immobilize a patient a prototype of a radiation chamber was built to provide a proof of concept. The radiation chamber frame was built to completely encapsulate the patient 360 degrees. The two airbags were placed in the frame which provides complete immobilization of the patient from all angles. The patient had to be standing while the radiation was being administered in order to target certain areas which could not be included if the patient was sitting or lying down. A circular frame was the desired shape of the frame because it allows for radiation to enter and exit the chamber at the same angle regardless of where it is administered. The radiation chamber requires the use of radiation safe materials in any given area where the frame comes into contact with radiation, for this reason non-metallic materials were used. The chamber prototype was built using wood and plexiglass. Finite element analysis simulated an allowable applied pressure of 6.0 Psi applied to the shell. Prior to the given prototype, there was no means available to immobilize a patient while standing for radiotherapy. Experimental tests demonstrated that a person could be immobilized in the general torso area using air.https://scholarscompass.vcu.edu/capstone/1214/thumbnail.jp

Underemployment, Education, and Job Satisfaction

The economic role of human capital, particularly education has long been documented by economists and policy makers [Becker (1964)]. According to some observers view, educational system is an effective vehicle for producing the skills required to maintain growth in the economy.1 The versatile impact of education on every aspect of human existence makes it a vital area for policy framework especially for developing countries. Developing countries where majority of world’s population resides need to maximise productivity and capabilities of the advanced human capital. The benefits of education range from human to economic, social and cultural. At human level, education contributes in attractive self esteem and confidence leading towards empowerment. In Pakistan, there is significant rise in the average level of education, but over time, more and more workers incapable to use their educational background on the job. Two decades ago, it was judgment that supply of labour meeting the demand of labour. However in recent years, it is argued that supply of some skilled labour may have outstripped the demand of labour in some professions and high qualified peoples taking positions of low qualified peoples. Such underemployment/over-education has not been fully explored in Pakistan

Trend analysis of lab tests requisitions of COVID-19 prognostic biomarkers at a clinical chemistry reference laboratory-an observational study

Background: Biochemical parameters, such as C-reactive protein (C-RP), Procalcitonin (PCT), Lactate dehydrogenase (LDH) and Ferritin are associated with COVID-19 severity and prognosis. This trend analysis of COVID-19 prognostic biomarker requisitions is aimed at providing a reflection of the clinical practices adopted amidst the peak of the pandemic. This knowledge of the prognostic biomarkers utilized, will further aid to classify patients based on their risk, for optimal resource allocation and improve outcomes.Material & methods: This cross-sectional study was conducted at the clinical chemistry laboratory at the Aga Khan University Hospital (AKUH), Karachi Pakistan. A team consisting of two clinical chemistry consultants reviewed the COVID-19 prognostic biomarkers tests performance data from March to July 2020 using the integrated laboratory information management system (ILMS). The test statistics of March to July 2020 when COVID-19 cases were on the rise in the country were compared with those of the same months from 2019. The changes in the test groups were expressed in percentages. Microsoft Excel for windows 2019 was used for data analysis.Results: The total specimens received for testing in 2020 (n = 574,092) showed a percent decline of approximately (-) 33% compared to 2019 (n = 858,756). Contrary to the overall decline in volumes an upward surge was noted for the prognostic biomarkers. From March to July, the highest percent change was noted for LDH (+155.1%), followed by PCT (+66.7.1%), C-RP (+26.5%) and Ferritin (+22.1%) in 2020 compared to the same time frame in 2019. The highest percent change was noted in June.Conclusion: During the COVID 19 pandemic, a significant increase in utilization of laboratory services was seen for COVID-19 prognostic markers

A Blockchain-Based Framework for Distributed Agile Software Testing Life Cycle

A blockchain-based framework for distributed agile software testing life cycle is an innovative approach that uses blockchain technology to optimize the software testing process. Previously, various methods were employed to address communication and collaboration challenges in software testing, but they were deficient in aspects such as trust, traceability, and security. Additionally, a significant cause of project failure was the non-completion of unit testing by developers, leading to delayed testing. This paper integration of blockchain technology in software testing resolves critical concerns related to transparency, trust, coordination, and communication. We have proposed a blockchain based framework named as TestingPlus. TestingPlus framework utilizes blockchain technology to provide a secure and transparent platform for acceptance testing and payment verification. By leveraging smart contracts on a private Ethereum blockchain, TestingPlus can help to ensure that both the testing team and the development team are working towards a common goal and are compensated fairly for their contributions.Comment: 4 figures, 12 page

Inaugural Address

Dr Sarfraz Khan Qureshi, Director of Pakistan Institute of Development Economics, Distinguished Guests, Ladies and Gentlemen, It is a great pleasure for me to be present here this morning. Over the years, the Pakistan Society of Development Economists has made notable contributions to the profession of Economics and Planning. It has also helped to strengthen the evolution of scientific knowledge in Development Economics. More importantly, it has given an institutional shape to the exchange of ideas between economists, other social scientists, and policy-makers. I am happy to note that a large number of distinguished academics and policy-makers from all over the world regularly participate in the Society’s meetings. I earnestly hope that useful policy prescriptions will emerge from the deliberations that take place here about the major issues in economy. Indeed, I wish to extend my appreciation to the Society for providing a lively and effective platform both to researchers and policy-makers

Fungi - an Amalgam of Toxins and Antibiotics: a Mini- Review

Fungi are eukaryotes with many functions. Earlier, fungi were classified in the plant kingdom but were later classified as a separate kingdom due to their unique cell walls. Fungi are heterotrophs like animals and are more closely related to animals. The perception of fungi is inconspicuous due to their small sizes and their ability to grow symbiotically in plants, animals, other fungi, and parasites. Fungi are used for their nutrition, fermentation potential, and bactericidal potential. However, fungi are also toxic due to certain bioactive compounds known as mycotoxins. Candida and Aspergillus are invasive species that contribute to a high percentage of mycoses in oncological and haematological patients. The mortality rate due to invasive aspergillosis and candidiasis is high, at 4% and 2%, respectively. In the agriculture sector, a significant contributor to damage to crops globally is the invasion of filamentous fungi. Fungi invasion destroys over 125 million tons of wheat, rice, soybeans, potatoes, and maize annually. If prevented, 600 million people may be fed. Therefore, it is vital to consider the dual role of fungi, therapeutic, and pathogenic

Environmental and food allergens reactivity and its association with total IgE, age and gender in Karachi, Pakistan

Aim: The aim of this study is to assess the frequency of food and environmental allergens reactivity and its association in with age, gender and total IgE levelsMaterial and Methods: The study population consisted of 88 individuals including children and adults (male: 47 and female: 41). The study was conducted in the clinical laboratory, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital from May 2009 till May 2010. Sera of patients positive for total IgE were tested for allergen specific IgE levels by Immulite 2000, 3gAllergyTM. We divided allergens into two panels, namely food and environmental.Results: There were a total of 27 allergens tested on 88 individuals who had elevated levels of total IgE. Median age was 18 yrs. (IQR 8-36). We have analyzed the data on two cutoffs of allergen specific IgE reactivity i.e. moderate (0.7-3.49 kU/L) and high (3.5-17.49 kU/L). In the environmental allergens group the moderate rates of reactivity were to dog epithelium (46.6%), mites (33%) and cockroach. (17%). From food panel moderate reactivity were to egg white (23.9%), milk (22.7%) and soybean (13.6%). High reactivity rates were seen to mites (6.8%), cockroach (4.5%), cat dander epithelium (3.4%), D.farinae (3.4%), molds (3.4%) and weeds (3.4%). Commonest food allergens with high reactivity were egg white (2.3%), peanuts (2.3%) and shrimps (2.3%). Very high reactivity of environmental allergens (\u3e52.50 kU/L) were mites (2.3%), cat dander epithelium (1.1%) whereas in food panel it was shrimps (1.1%) and peanuts (1.1%). Positive significant association of food allergens reactivity is seen with gender (p=0.01), age (p ≤ 0.001) and total IgE (p=0.05). On the other hand positive significant association of environmental allergens reactivity is seen with age (p=0.02) and total IgE (p ≤ 0.001).Conclusion: Mites, cat dander, dog epithelium and cockroach were the most frequent environmental allergens and egg white, peanuts and shrimps were the most prevalent food allergens. There was a positive correlation between age, gender, total IgE levels and IgE specific allergens. Our study demonstrates high rates of reactivity to major environmental and food allergens in patients with high total IgE