Observations on the linguistic epigraphic choice in late antique inscriptions from Malta

The aim of this paper is to reconsider the Maltese epigraphic material from a linguistic point of view, with an attempt to point out what the specific linguistic choice means within the epigraphic context. Analysing the epigraphic data, it is possible to suppose that in late antiquity the Greek-speaking community in Malta was linked to a Jewish community maybe coming from abroad. Furthermore, a parallel can be established with the south-eastern area in Sicily, where there is evidence for the presence of Jewish burial places in Christian necropoleis, with the preponderance of Greek used as epigraphic language. The choice of Greek for the funerary inscriptions from Malta does not tend to be arbitrary, and might indicate the persistent use of the original language of an immigrant community.peer-reviewe

Observations on the linguistic epigraphic choice in late antique inscriptions from Malta

The aim of this paper is to reconsider the Maltese Epigraphic material from a linguistic point of view, with an attempt to point out what the speciic linguistic choice means within the epigraphic context. Analysing the epigraphic data, it is possible to suppose that in late antiquity the Greek-speaking community in Malta was linked to a Jewish community maybe coming from abroad. Furthermore, a parallel can be established with the south-eastern area in Sicily, where there is evidence for the presence of Jewish burial places in Christian necropoleis, with the preponderance of Greek used as epigraphic language. he choice of Greek for the funerary inscriptions from Malta does not tend to be arbitrary, and might indicate the persistent use of the original language of an immigrant community

Motor neuron degeneration, severe myopathy and TDP-43 increase in a transgenic pig model of SOD1-linked familiar ALS

Amyotrophic Lateral Sclerosis (ALS) is a neural disorder gradually leading to paralysis of the whole body. Alterations in superoxide dismutase SOD1 gene have been linked with several variants of familial ALS. Here, we investigated a transgenic (Tg) cloned swine model expressing the human pathological hSOD1G93A allele. As in patients, these Tg pigs transmitted the disease to the progeny with an autosomal dominant trait and showed ALS onset from about 27 months of age. Post mortem analysis revealed motor neuron (MN) degeneration, gliosis and hSOD1 protein aggregates in brainstem and spinal cord. Severe skeletal muscle pathology including necrosis and inflammation was observed at the end stage, as well. Remarkably, as in human patients, these Tg pigs showed a quite long presymptomatic phase in which gradually increasing amounts of TDP-43 were detected in peripheral blood mononuclear cells. Thus, this transgenic swine model opens the unique opportunity to investigate ALS biomarkers even before disease onset other than testing novel drugs and possible medical devices