Risk Mitigation through Diversified Farm Production Strategies: The Case in Northern Mozambique

Mozambique, like many other parts of the low-income world, faces perennial challenges with food security. With a rapidly growing population and arable land on the decline, sustainable agriculture is vital to managing the already depleted natural resources of Sub-Saharan Africa more effectively while increasing food security. Food security issues for subsistence farmers in most low-income countries are a product of endogenous (crop yields) and exogenous (currency fluctuations as many agricultural inputs are imported) factors. In Mozambique the value of the local currency, meticals, has decreased by approximately 50% since January 2015 compared to the U.S. dollar. While this makes exporting products out of Mozambique more attractive in a relative sense, it negatively effects those industries which rely on imported inputs such as animal feed and inorganic fertilizer. In response to this exogenous currency crisis, research was conducted in Nampula, Mozambique during the summer of 2016 on a method for implementing crop diversification to reduce the risk that accompanies the devaluation of the metical. This research was undertaken on a poultry operation which is heavily dependent on imported maize and soya. Similar to the market structure of the poultry industry in the United States, all birds are grown by individual out growers who typically also have small plots of land to farm. Objectives for the project included 1) perform on-site crop production evaluations, 2) determine profitability for various row crops, and 3) simulate alternative production practices to increase crop profitability. Of the crops grown (tomatoes, maize, and cabbage), maize required the least labor, lowest initial investment, and the highest probability of breaking even. This research concluded that if poultry producers in Mozambique who rely on imported feed grew maize simultaneously it would reduce the dependency on imported maize and reduce income variability associated with exogenous currency fluctuations. Implementing a program such as this could increase revenue streams as well as reduce variability, thereby enhancing regional food securit

Risk Mitigation through Diversified Farm Production Strategies: The Case in Northern Mozambique

Mozambique, like many other parts of the low-income world, faces perennial challenges with food security. With a rapidly growing population and arable land on the decline, sustainable agriculture is vital to managing the already depleted natural resources of Sub-Saharan Africa more effectively while increasing food security. Food security issues for subsistence farmers in most low-income countries are a product of endogenous (crop yields) and exogenous (currency fluctuations as many agricultural inputs are imported) factors. In Mozambique the value of the local currency, meticals, has decreased by approximately 50% since January 2015 compared to the U.S. dollar. While this makes exporting products out of Mozambique more attractive in a relative sense, it negatively effects those industries which rely on imported inputs such as animal feed and inorganic fertilizer. In response to this exogenous currency crisis, research was conducted in Nampula, Mozambique during the summer of 2016 on a method for implementing crop diversification to reduce the risk that accompanies the devaluation of the metical. This research was undertaken on a poultry operation which is heavily dependent on imported maize and soya. Similar to the market structure of the poultry industry in the United States, all birds are grown by individual out growers who typically also have small plots of land to farm. Objectives for the project included 1) perform on-site crop production evaluations, 2) determine profitability for various row crops, and 3) simulate alternative production practices to increase crop profitability. Of the crops grown (tomatoes, maize, and cabbage), maize required the least labor, lowest initial investment, and the highest probability of breaking even. This research concluded that if poultry producers in Mozambique who rely on imported feed grew maize simultaneously it would reduce the dependency on imported maize and reduce income variability associated with exogenous currency fluctuations. Implementing a program such as this could increase revenue streams as well as reduce variability, thereby enhancing regional food securit

Achilles tendon material properties are greater in the jump leg of jumping athletes

Purpose: The Achilles tendon (AT) must adapt to meet changes in demands. This study explored AT adaptation by comparing properties within the jump and non-jump legs of jumping athletes. Non-jumping control athletes were included to control limb dominance effects. Methods: AT properties were assessed in the preferred (jump) and non-preferred (lead) jumping legs of male collegiate-level long and/or high jump (jumpers; n=10) and cross-country (controls; n=10) athletes. Cross-sectional area (CSA), elongation, and force during isometric contractions were used to estimate the morphological, mechanical and material properties of the ATs bilaterally. Results: Jumpers exposed their ATs to more force and stress than controls (all p≤0.03). AT force and stress were also greater in the jump leg of both jumpers and controls than in the lead leg (all p0.05). Conclusion: ATs chronically exposed to elevated mechanical loading were found to exhibit greater mechanical (stiffness) and material (Young’s modulus) properties

What stops children with a chronic illness accessing health care: A mixed methods study in children with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)

Background: Paediatric Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is relatively common and disabling with a mean time out of school of more than one academic year. NICE guidelines recommend referral to specialist services immediately if severely affected, within 3 months if moderately affected and within 6 months if mildly affected. However, the median time-to-assessment by a specialist service in the UK is 18 months. This study used a mixed-methods approach to examine factors associated with time taken to access specialist services. Methods. Time-to-assessment was analysed as a continuous "survival-time" variable in Cox regression models using data from self-completed assessment forms for children attending a regional specialist CFS/ME service between January 2006 and December 2009. Semi-structured interviews about barriers experienced in accessing healthcare for their child were conducted with nine parents of children aged < 17 years (8 individual and one parent couple). Interviews were digitally recorded and analysed using "thematic analysis". Results: 405 children were assessed between 2006 and 2009 and information on school attendance was available on 388. Only 1/125 with severe CFS/ME and 49/263 (19%) with mild to moderate CFS/ME were seen within NICE recommended timeframe. Increased fatigue was associated with shorter time to assessment (HR = 1.15; 95% CI 1.03, 1.29 per unit increase in Chalder fatigue score; P = 0.01). Time-to-assessment was not associated with disability, mood, age or gender. Parents described difficulties accessing specialist services because of their own as well as their GP's and Paediatrician's lack of knowledge. They experienced negative attitudes and beliefs towards the child's condition when they consulted GPs, Paediatricians and Child Psychiatrists. Parents struggled to communicate an invisible illness that their child and not themselves were experiencing. Conclusions: GPs, Child Psychiatrists and Paediatricians need more knowledge about CFS/ME and the appropriate referral pathways to ensure timeliness in referral to specialist services. © 2011 Webb et al; licensee BioMed Central Ltd

Gene expression profiling of tumour epithelial and stromal compartments during breast cancer progression

The progression of ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) marks a critical step in the evolution of breast cancer. There is some evidence to suggest that dynamic interactions between the neoplastic cells and the tumour microenvironment play an important role. Using the whole-genome cDNA-mediated annealing, selection, extension and ligation assay (WG-DASL, Illumina), we performed gene expression profiling on 87 formalin-fixed paraffin-embedded (FFPE) samples from 17 patients consisting of matched IDC, DCIS and three types of stroma: IDC-S ( 10 mm from IDC or DCIS). Differential gene expression analysis was validated by quantitative real time-PCR, immunohistochemistry and immunofluorescence. The expression of several genes was down-regulated in stroma from cancer patients relative to normal stroma from reduction mammoplasties. In contrast, neoplastic epithelium underwent more gene expression changes during progression, including down regulation of SFRP1. In particular, we observed that molecules related to extracellular matrix (ECM) remodelling (e.g. COL11A1, COL5A2 and MMP13) were differentially expressed between DCIS and IDC. COL11A1 was overexpressed in IDC relative to DCIS and was expressed by both the epithelial and stromal compartments but was enriched in invading neoplastic epithelial cells. The contributions of both the epithelial and stromal compartments to the clinically important scenario of progression from DCIS to IDC. Gene expression profiles, we identified differential expression of genes related to ECM remodelling, and specifically the elevated expression of genes such as COL11A1, COL5A2 and MMP13 in epithelial cells of IDC. We propose that these expression changes could be involved in facilitating the transition from in situ disease to invasive cancer and may thus mark a critical point in disease development

Genetic Ancestry, Social Classification, and Racial Inequalities in Blood Pressure in Southeastern Puerto Rico

The role of race in human genetics and biomedical research is among the most contested issues in science. Much debate centers on the relative importance of genetic versus sociocultural factors in explaining racial inequalities in health. However, few studies integrate genetic and sociocultural data to test competing explanations directly.We draw on ethnographic, epidemiologic, and genetic data collected in Southeastern Puerto Rico to isolate two distinct variables for which race is often used as a proxy: genetic ancestry versus social classification. We show that color, an aspect of social classification based on the culturally defined meaning of race in Puerto Rico, better predicts blood pressure than does a genetic-based estimate of continental ancestry. We also find that incorporating sociocultural variables reveals a new and significant association between a candidate gene polymorphism for hypertension (alpha(2C) adrenergic receptor deletion) and blood pressure.This study addresses the recognized need to measure both genetic and sociocultural factors in research on racial inequalities in health. Our preliminary results provide the most direct evidence to date that previously reported associations between genetic ancestry and health may be attributable to sociocultural factors related to race and racism, rather than to functional genetic differences between racially defined groups. Our results also imply that including sociocultural variables in future research may improve our ability to detect significant allele-phenotype associations. Thus, measuring sociocultural factors related to race may both empower future genetic association studies and help to clarify the biological consequences of social inequalities