Two Minimal Clinically Important Difference (2MCID) : A New Twist on an Old Concept

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Comparison of efficacy of methylprednisolone with dexamethasone in moderate to severe COVD-19 patients in a tertiary care hospital

Background: The aim was to compare efficacy of methylprednisolone with dexamethasone in moderate to severe COVID-19 patients in a tertiary care hospital. Method: A retrospective observational study was conducted by collecting data of moderate to severe COVID-19 patients admitted to covid wards of a tertiary care hospital for a period of six months. Demographic data, information about SpO2 changes, duration of hospitalization, marker status and ventilation status were parameters collected and used to compare between two groups. Results: Total number of patients in this study were 130. Out of which 65 patients who were on Methylprednisolone belonged to group A and 65 patients taking dexamethasone belonged to group B. In group A 56 (86.2%) were males and 9 (13.8%) were females. In group B 51 (78.5%) were males and 14 (21.5%) were females. Mean age in group A was 54.75±14.96 (age range b/w 25-80 years) and in group B was 55.43±15.83 (age range between 23-84 years). Patients in group A showed more presence of comorbidity (44.6%) as compared to group B (32.3%). Mean SpO2 level on day 1 in group A was 86.37±7.58 and in group B was 88.11±4.38. On day of discharge mean SpO2 level was 95.05±1.54 in group A and 94.63±2.09 in group B. Mean length of hospital stay in group A was 9.78±7.38 and in group B was 7.88±4.76. Improvement in marker status for group A was 100% and for group B 95.4%. Ventilation status in both groups showed 100% improvement. Conclusions: Both steroids are effective in management of moderate to severe COVID-19 patients

DRESS syndrome due to clobazam: a case report

Drug rash (or reaction) with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening hypersensitivity reaction to drugs characterized by rash, fever, lymphadenopathy, hematologic abnormalities, and involvement of internal organs. Initially coined in 1996, the term is used to refer to an idiosyncratic reaction to several drugs, the most common of which are carbamazepine, allopurinol, sulfasalazine, and phenobarbital. We report the case of DRESS related to clobazam in a 38-year-old female with a history of a complex seizure disorder

An effective modification of the homotopy perturbation method for MHD viscous flow over a stretching sheet

AbstractIn this paper, we propose a powerful modification of the homotopy perturbation method that will accelerate the rapid convergence of series solution. The modified method is employed to solve the MHD boundary-layer equations. The viscous fluid is electrically conducting in the presence of a uniform applied magnetic field and the induced magnetic field is neglected for small magnetic Reynolds number. Similarity solutions of ordinary differential equation resulting from the momentum equation are obtained. Finally, some numerical comparisons among the new modified homotopy perturbation method, the standard homotopy perturbation, the Exact Solution and the Shooting method have been made, which manifest that the modified method is a very accurate and effective algorithm to solve the two-dimensional MHD viscous flow over a stretching sheet

Fractional variational iteration method via modified Riemann–Liouville derivative

AbstractThe aim of this paper is to present an efficient and reliable treatment of the variational iteration method (VIM) for partial differential equations with fractional time derivative. The fractional derivative is described in the Jumarie sense. The obtained results are in good agreement with the existing ones in open literature and it is shown that the technique introduced here is robust, efficient and easy to implement