11 research outputs found
Parameters of the attenuated schistosome vaccine evaluated in the olive baboon
Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens. Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response
Etudes pour dĂ©terminer la sĂ©curitĂ© dâun gel contraceptif microbicide (UniPron) chez les babouins ( Papio anubis ) qui viennent dâĂȘtre mis au point
To identify any toxicity on the vaginal epithelium, liver and kidney
following UniPron administration, ten healthy female olive baboons (
Papio anubis ) of reproductive age and of proven fertility were used.
Five baboons were each treated with 15g of UniPron intravaginally twice
a week for 20-weeks and venous blood collected before and after each
treatment. Venous blood was collected from five control animals as in
the experimental females, but these control animals were not given any
treatment. The endpoints that were evaluated included clinical
chemistry profiles on kidney and liver functions and vaginal
histopathology. Female baboons treated with 15g of UniPron
intravaginally showed no detectable adverse effects on clinical
chemistry profiles investigated and vaginal histopathology. Repeated
intravaginal exposure of female baboons to UniPron did not induce
detectable vaginal irritation and there were no detectable histological
changes. We conclude that administration of UniPron into baboon vagina
did not cause any detectable toxicity (Afr J Reprod Health 2009;
13[4]:95-104).Pour identifier la présence de la toxicité sur
lâĂ©pithĂ©lium vaginal, la foie et le rein suite
dâune administration dâUniPron, nous avons utilisĂ© dix
babouins ( Papio anubis ) olivùtres en bonne santé qui
Ă©taient en Ăąge de procrĂ©er et dâune
fécondité confirmée. Cinq babouins ont été
soignĂ©s chacune au 15g dâUniPron par voie intravaginale deux
fois par semaine pendant 20 semaines et le sang veineux a été
collecté avant et aprÚs chaque traitement. Le sang veineux a
été collecté de cinq animaux témoin comme dans le
cas des femelles dâexpĂ©rience, mais ces animaux tĂ©moin
nâont pas Ă©tĂ© traitĂ©s. Les rĂ©sultats qui ont
été analysés ont compris les profils chimiques clinques
sur les fonctions de la foie et du rein et lâhistopathologie
vaginale. Les babouins femelles qui ont été soignées au
15g dâUniPron par voie intravaginale nâont pas eu
dâeffets nĂ©gatifs dĂ©tectables sur les profils chimiques
Ă©tudiĂ©s et sur lâhistopathologie. Lâexposition
intravaginale répétée des babouins femelles a UniPron
nâa pas dĂ©clenchĂ© lâirritation vaginale
dĂ©tectable et il nây avait pas de modifications
histologiques détectables. Nous avons conclu que
lâadministration dâUniPron dans le vagin du babouin
nâa causĂ© aucune toxicitĂ© dĂ©testable (Afr J Reprod
Health 2009; 13[4]:95-104)
The role of scientists and clinicians in raising public support for animal research in reproductive biology and medicine
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