2,043 research outputs found
Structural studies of mesoporous ZrO-CeO and ZrO-CeO/SiO mixed oxides for catalytical applications
In this work the synthesis of ZrO-CeO and
ZrO-CeO/SiO were developed, based on the process to form
ordered mesoporous materials such as SBA-15 silica. The triblock copolymer
Pluronic P-123 was used as template, aiming to obtain crystalline single phase
walls and larger specific surface area, for future applications in catalysis.
SAXS and XRD results showed a relationship between ordered pores and the
material crystallization. 90% of CeO leaded to single phase homogeneous
ceria-zirconia solid solution of cubic fluorite structure (Fmm). The
SiO addition improved structural and textural properties as well as the
reduction behavior at lower temperatures, investigated by XANES measurements
under H atmosphere
Tumor infiltrating regulatory t cells in sporadic and colitis-associated colorectal cancer: The red little riding hood and the wolf
Regulatory T cells represent a class of specialized T lymphocytes that suppress unwanted immune responses and size the activation of the immune system whereby limiting collateral damages in tissues involved by inflammation. In cancer, the accumulation of Tregs is generally associated with poor prognosis. Many lines of evidence indicate that Tregs accumulation in the tumor microenvironment (TME) suppresses the immune response against tumor-associated antigens (TAA), thus promoting tumor progression in non-small cell lung carcinoma (NSLC), breast carcinoma and melanoma. In colorectal cancer (CRC) the effect of Tregs accumulation is debated. Some reports describe the association of high number of Tregs in CRC stroma with a better prognosis while others failed to find any association. These discordant results stem from the heterogeneity of the immune environment generated in CRC in which anticancer immune response may coexists with tumor promoting inflammation. Moreover, different subsets of Tregs have been identified that may exert different effects on cancer progression depending on tumor stage and their location within the tumor mass. Finally, Tregs phenotypic plasticity may be induced by cytokines released in the TME by dysplastic and other tumor-infiltrating cells thus affecting their functional role in the tumor. Here, we reviewed the recent literature about the role of Tregs in CRC and in colitis-associated colorectal cancer (CAC), where inflammation is the main driver of tumor initiation and progression. We tried to explain when and how Tregs can be considered to be the “good” or the “bad” in the colon carcinogenesis process on the basis of the available data concluding that the final effect of Tregs on sporadic CRC and CAC depends on their localization within the tumor, the subtype of Tregs involved and their phenotypic plasticity
Raman excitation spectroscopy of carbon nanotubes: effects of pressure medium and pressure
Raman excitation and emission spectra for the radial breathing mode (RBM) are
reported, together with a preliminary analysis. From the position of the peaks
on the two-dimensional plot of excitation resonance energy against Raman shift,
the chiral indices (m, n) for each peak are identified. Peaks shift from their
positions in air when different pressure media are added - water, hexane,
sulphuric acid - and when the nanotubes are unbundled in water with surfactant
and sonication. The shift is about 2 - 3 cm-1 in RBM frequency, but
unexpectedly large in resonance energy, being spread over up to 100meV for a
given peak. This contrasts with the effect of pressure. The shift of the peaks
of semiconducting nanotubes in water under pressure is orthogonal to the shift
from air to water. This permits the separation of the effects of the pressure
medium and the pressure, and will enable the true pressure coefficients of the
RBM and the other Raman peaks for each (m, n) to be established unambiguously.Comment: 6 pages, 3 Figures, Proceedings of EHPRG 2011 (Paris
A new electric streamer for the characterization of river embankments
River embankments are linear earth structures, worldwide diffused, commonly used for flood protection. Their integrity and stability are fundamental prerequisites for the protection efficiency they can offer to the increasing frequency and magnitude of extreme flood events associated to changes in climate. Proper characterization and monitoring are essential to verify the construction requirements of newly built structures and to evaluate the durability of aged ones. Considering their linear extent, the characterization requires not only local geotechnical investigations but also the application of efficient and economically affordable methods. This is even more essential when the investigations are performed after, or in foresee of, significant flood events, when these structures get stressed and timing of the surveys is crucial. In these conditions, new survey methodologies, with the use of mobile systems, are a main research topic. In this paper the application of a new electric streamer, specifically designed for these aims, is presented. The technical solutions adopted for its construction are described and its application to the characterization of three different river embankments is presented. These case studies were chosen in accordance with the Po River Interregional Agency (AIPO), which is the authority deputed to the safety of flood protection structures in North-West Italy, along the hydrographic network of the Po River. The selected embankments are all earth structures, constructed above the natural alluvial soils, but are characterized by different conditions and challenges. The results obtained with the new system were comparable to standard Electric Resistivity Tomography (ERT) methods. The new system has significant advantages in terms of reducing the survey time, improving the efficiency of the surveys and increasing the data coverage. This resulted in a better definition of potentially dangerous anomalies
Inhibitory Effect of Quercetin on Oxidative Endogen Enzymes: A Focus on Putative Binding Modes
Oxidative stress is defined as an imbalance between the production of free radicals and reactive oxygen species (ROS) and the ability of the body to neutralize them by anti-oxidant defense systems. Cells can produce ROS during physiological processes, but excessive ROS can lead to non-specific and irreversible damage to biological molecules, such as DNA, lipids, and proteins. Mitochondria mainly produce endogenous ROS during both physiological and pathological conditions. Enzymes like nicotinamide adenine dinucleotide phosphate oxidase (NOX), xanthine oxidase (XO), lipoxygenase (LOX), myeloperoxidase (MPO), and monoamine oxidase (MAO) contribute to this process. The body has enzymatic and non-enzymatic defense systems to neutralize ROS. The intake of bioactive phenols, like quercetin (Que), can protect against pro-oxidative damage by quenching ROS through a non-enzymatic system. In this study, we evaluate the ability of Que to target endogenous oxidant enzymes involved in ROS production and explore the mechanisms of action underlying its anti-oxidant properties. Que can act as a free radical scavenger by donating electrons through the negative charges in its phenolic and ketone groups. Additionally, it can effectively inhibit the activity of several endogenous oxidative enzymes by binding them with high affinity and specificity. Que had the best molecular docking results with XO, followed by MAO-A, 5-LOX, NOX, and MPO. Que's binding to these enzymes was confirmed by subsequent molecular dynamics, revealing different stability phases depending on the enzyme bound. The 500 ns simulation showed a net evolution of binding for NOX and MPO. These findings suggest that Que has potential as a natural therapy for diseases related to oxidative stress
Secondary forest succession in the Mata Atlantica, Brazil: floristic and phytosociological trends.
This study aimed at understanding the dynamics of ecological processes and the use of secondary forests in Santa Catarina state (Brazil). The data base for these studies was formed through forest inventories carried out in the three forest types of the state. The results of this study demonstrate that the patterns of diversity are very similar among the three forest types; however, the species compositions among the types are quite different. A total of 343 woody species belonging to 73 families were found in the 24,000 m2 sampling area, revealing the potential role of secondary forest in the conservation of biodiversity at the landscape scale. As expected, a small set of pioneer species dominates young secondary forests with shade-tolerant species becoming structurally important after 30 years. The patterns of forest structure and species diversity observed in study largely conform to the postagricultural secondary succession observed for many tropical forests.Article ID 759893
Strategies to prevent the presence of a dominant follicle (DF) between days 15 and 20 of the cow estrous cycle.
Signals to their parliaments? Governments’ use of votes and policy statements in the EU Council
Does parliamentary oversight of governments’ decisions in the international arena matter? This article finds that it does: governments with strong parliamentary oversight behave differently when negotiating policies at the EU level compared with governments with less powerful parliaments. Where parliaments have formal powers to oversee and restrict their government's positions we see a significantly higher use of opposing votes and formal policy statements by those governments. This behaviour intensifies depending on the governments' standing vis‐à‐vis other political parties at home. When governments are under pressure in their national parliaments they are more likely to go on record and take a stand against the majority in Brussels. These results make it clear that in EU legislative politics, governments not only consider their policy priorities and negotiation tactics with their European counterparts, but also make use of EU decision records to send signals to domestic audiences, including their national parliaments
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