4-Nitro­phenyl N-phenyl­carbamate

The title compound, C13H10N2O4, was synthesized as an inter­mediate for the preparation of ureas. The two aromatic rings are twisted about the central carbamate group with a C—C—N—C torsion angle of 139.6 (2)° and a C—C—O—C torsion angle of 95.9 (2)°. The mol­ecules are linked into one-dimensional chains by N—H⋯O hydrogen bonds along the b axis. Weak inter­actions between O atoms of the nitro groups (O⋯O = 3.012 Å) connect two adjacent chains

2-Chloro-4-iodo­aniline

The title dihaloaniline, C6H5ClIN, shows no significant hydrogen bonds nor the commonly observed I⋯I inter­actions in the crystal structure, although an amino group and an I atom are available for such contacts. The crystal structure is stabilized by weak inter­actions involving the amine functionality as donor group and N or halogen atoms as acceptors

A Novel Bitriazolyl Acyclonucleoside Endowed with Dual Antiproliferative and Immunomodulatory Activity

International audienceA novel bitriazolyl acyclonucleoside was discovered to exhibit powerful antiproliferative effects on different cancer cell lines through caspase-dependent apoptosis and at the same time stimulate the immune response in dendritic cells via Toll-like receptor 7 (TLR7) signaling. This promising compound with dual anticancer and immunomodulatory activity may represent a new generation of highly efficacious drug candidates for use in cancer therapy

Mimicking the 2-oxoglutaric acid signalling function using molecular probes: insights from structural and functional investigations

2-Oxoglutaric acid (2-OG) has gained considerable attention because of its newly discovered signalling role in addition to its established metabolic functions. With the aim of further exploring the signalling function of 2-OG, here we present a structure-activity relationship study using 2-OG probes bearing different carbon chain lengths and terminal groups. Our results highlight the importance of the five-membered carbon molecular skeleton and of the two carboxylic terminals in maintaining the signalling functions of the parent molecule 2-OG. These findings provide valuable information for designing new, effective molecular probes able to dissect and discriminate the newly discovered, complex signalling role of 2-OG from its canonical activity in metabolism