Key Topics in Deep Geological Disposal : Conference Report (KIT Scientific Reports ; 7696)

The current state of knowledge of central aspects of radioactive waste repository research was presented in the course of the DAEF conference "Key topics in deep geological disposal". For the first time socio-economic and socio-technical issues played an important role within a conference focusing on the disposal of radioactive waste. Scientists from about 16 different countries presented their scientific work in 8 sessions and during a poster session

Annual Report 2015 / Institute for Nuclear Waste Disposal. (KIT Scientific Reports ; 7725)

The contributions collected in this report provide a representative overview of the scientific outcome of INE research activities in 2015. The structure of the report follows widely the organization of the institute according to research topics: basic research towards understanding geochemical reactions of radionuclides on a molecular scale and applied studies on radionuclide retention in multi-barrier system under real repository conditions

Annual Report 2014 / Institute for Nuclear Waste Disposal. (KIT Scientific Reports ; 7709)

The contributions collected in this report provide a representative overview of the scientific outcome of INE research activities in 2014. The structure of the report follows widely the organization of the institute according to research topics: basic research towards understanding geochemical reactions of radionuclides on a molecular scale and applied studies on radionuclide retention in multi-barrier system under real repository conditions

Replication of the association of chromosomal region 9p21.3 with generalized aggressive periodontitis (gAgP) using an independent case-control cohort

Background: The human chromosomal region 9p21.3 has been shown to be strongly associated with Coronary Heart Disease (CHD) in several Genome-wide Association Studies (GWAS). Recently, this region has also been shown to be associated with Aggressive Periodontitis (AgP), strengthening the hypothesis that the established epidemiological association between periodontitis and CHD is caused by a shared genetic background, in addition to common environmental and behavioural risk factors. However, the size of the analyzed cohorts in this primary analysis was small compared to other association studies on complex diseases. Using our own AgP cohort, we attempted to confirm the described associations for the chromosomal region 9p21.3. Methods: We analyzed our cohort consisting of patients suffering from the most severe form of AgP, generalized AgP (gAgP) (n = 130) and appropriate periodontally healthy control individuals (n = 339) by genotyping four tagging SNPs (rs2891168, rs1333042, rs1333048 and rs496892), located in the chromosomal region 9p21.3, that have been associated with AgP. Results: The results confirmed significant associations between three of the four SNPs and gAgP. The combination of our results with those from the study which described this association for the first time in a meta-analysis of the four tagging SNPs produced clearly lower p-values compared with the results of each individual study. According to these results, the most plausible genetic model for the association of all four tested SNPs with gAgP seems to be the multiplicative one. Conclusion: We positively replicated the finding of an association between the chromosomal region 9p21.3 and gAgP. This result strengthens support for the hypothesis that shared susceptibility genes within this chromosomal locus might be involved in the pathogenesis of both CHD and gAgP

CD spectra of the CF₃-Bpg labeled TP10 analogs.

<p>CD spectra are recorded in the presence of unilamellar DMPC/DMPG (3∶1) vesicles at a P/L ratio of 1∶200. (A) <b><i>L</i></b><b>-</b>epimers and (B) <b><i>D</i></b><b>-</b>epimers are compared with the WT peptide (black line). Analogs with CF₃-Bpg in the galanin part are represented by green lines and in the mastoparan part by red lines.</p