Boosting Neural Machine Translation with Dependency-Scaled Self-Attention Network

Syntax knowledge contributes its powerful strength in Neural machine translation (NMT) tasks. Early NMT works supposed that syntax details can be automatically learned from numerous texts via attention networks. However, succeeding researches pointed out that limited by the uncontrolled nature of attention computation, the NMT model requires an external syntax to capture the deep syntactic awareness. Although existing syntax-aware NMT methods have bored great fruits in combining syntax, the additional workloads they introduced render the model heavy and slow. Particularly, these efforts scarcely involve the Transformer-based NMT and modify its core self-attention network (SAN). To this end, we propose a parameter-free, dependency-scaled self-attention network (Deps-SAN) for syntax-aware Transformer-based NMT. A quantified matrix of dependency closeness between tokens is constructed to impose explicit syntactic constraints into the SAN for learning syntactic details and dispelling the dispersion of attention distributions. Two knowledge sparsing techniques are further integrated to avoid the model overfitting the dependency noises introduce by the external parser. Experiments and analyses on IWSLT14 German-to-English and WMT16 German-to-English benchmark NMT tasks verify the effectiveness of our approach

Measuring the Quality of Financial Electronic Payment System: Combined with Fuzzy AHP and Fuzzy TOPSIS

The study aims to apply Fuzzy AHP in TOPSIS to discuss the key factors that foster the success of current third-party online payment platforms. This study organized the quality measurements into four categories and eleven sub-categories. The AHP in TOPSIS is applied to calculate the weighted averages of all categories and sub-categories to measure the quality of third-party online payment platforms. This study finds that “safety quality” is the most emphasized category, “system quality” is the second, “communication quality” is the third, and “service quality” is the least emphasized

Duration of untreated bipolar disorder: A multicenter study

Little is known about the demographic and clinical differences between short and long duration of untreated bipolar disorder (DUB) in Chinese patients. This study examined the demographic and clinical features of short (≤2 years) and long DUB (\u3e2 years) in China. A consecutively recruited sample of 555 patients with bipolar disorder (BD) was examined in 7 psychiatric hospitals and general hospital psychiatric units across China. Patients’ demographic and clinical characteristics were collected using a standardized protocol and data collection procedure. The mean DUB was 3.2 ± 6.0 years; long DUB accounted for 31.0% of the sample. Multivariate analyses revealed that longer duration of illness, diagnosis of BD type II, and earlier misdiagnosis of BD for major depressive disorder or schizophrenia were independently associated with long DUB. The mean DUB in Chinese BD patients was shorter than the reported figures from Western countries. The long-term impact of DUB on the outcome of BD is warranted

Hydrogen sulfide ameliorates isoflurane-induced cognitive impairment in mice: Implication of caspase-3 activation

Purpose: Isoflurane could induce cognitive impairment and activate caspase-3. However, the mechanism of action is unclear and target  interventions are unavailable. The present study examined the potential protective function of hydrogen sulfide (H2S) against isoflurane-induced cognitive impairment.Methods: Effects of NaHS (5 mg/kg) on cognitive impairment induced by isoflurane (1.4% for 2 h) were assessed using a fear-conditioning test in a group of 8-month old mice. H4 human neuroglioma cells, which were transfected with upregulated human amyloid precursor protein were treated for 3 or 6 h with 2% isoflurane, in the presence of 100-μM NaHS in the mice. A group of mice treated with normal saline in place of the NaHS in each case served as control. Western blotting, fluorescence assay, and a mitochondrial swelling assay were employed to observe the results of caspase-3 activation, mitochondrial dysfunction, and ROS and ATP levels.Results: NaHS significantly mitigated isoflurane-induced cognitive impairment in mice. In cultured cells, NaHS reduced caspase-3 activation, ROS, mitochondria membrane reduction, mitochondrial permeability transition pore opening, and cellular ATP level. NaHS could ameliorate cognitiveimpariment induced by isoflurane through inhibiting caspase-3 activation, oxidative stress, and mitochondrial dysfunction.Conclusion: These results indicate that hydrogen sulfide (H2S) has potential protective function against isoflurane-induced cognitive impairment. Further investigation of NaHS as an intervention to attenuate anesthesia-associated neurotoxicity is vital. Keywords: Hydrogen sulfide, isoflurane-cognition，fear conditioning，neurotoxicit

Bilateral Habenula deep brain stimulation for treatment-resistant depression: clinical findings and electrophysiological features.

Deep brain stimulation (DBS) of structures in the brain's reward system is a promising therapeutic option for patients with treatment-resistant depression (TRD). Recently, DBS of the habenula (HB) in the brain's anti-reward system has also been reported to alleviate depressive symptoms in patients with TRD or bipolar disorder (BD). In this pilot open-label prospective study, we explored the safety and clinical effectiveness of HB-DBS treatment in seven patients with TRD or BD. Also, local field potentials (LFPs) were recorded from the patients' left and right HB to explore the power and asymmetry of oscillatory activities as putative biomarkers of the underlying disease state. At 1-month follow-up (FU), depression and anxiety symptoms were both reduced by 49% (n = 7) along with substantial improvements in patients' health status, functional impairment, and quality of life. Although the dropout rate was high and large variability in clinical response existed, clinical improvements were generally maintained throughout the study [56%, 46%, and 64% reduction for depression and 61%, 48%, and 70% reduction for anxiety at 3-month FU (n = 5), 6-month FU (n = 5), and 12-month FU (n = 3), respectively]. After HB-DBS surgery, sustained improvements in mania symptoms were found in two patients who presented with mild hypomania at baseline. Another patient, however, experienced an acute manic episode 2 months after surgery that required hospitalization. Additionally, weaker and more symmetrical HB LFP oscillatory activities were associated with more severe depression and anxiety symptoms at baseline, in keeping with the hypothesis that HB dysfunction contributes to MDD pathophysiology. These preliminary findings indicate that HB-DBS may offer a valuable treatment option for depressive symptoms in patients who suffer from TRD or BD. Larger and well-controlled studies are warranted to examine the safety and efficacy of HB-DBS for treatment-refractory mood disorders in a more rigorous fashion

Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1–p38 Apoptosis Signaling

Danshen has been used in traditional Chinese medicine for hundreds of years to treat cardiovascular diseases. However, its precise cardioprotective components and the underlying mechanism are still unclear. In the present study, we demonstrated that in a rat model of acute myocardial infarction, the treatment with magnesium lithospermate B (MLB), the representative component of phenolic acids in Danshen, significantly reduced the infarct size and the blood lactate dehydrogenase level. In contrast, tanshinone IIA, the representative component of lipophilic tanshinones in Danshen, had no such protective effects. Moreover, in the simulated ischemia cell model, MLB treatment considerably increased the cell viability and reduced the sub-G1 population and the apoptotic nuclei, indicating its anti-apoptotic effect. Further mechanism study revealed that the ischemia-induced p38 phosphorylation was abolished by MLB treatment. Interestingly, MLB specifically inhibited the TGFβ-activated protein kinase 1-binding protein 1 (TAB1) mediated p38 phosphorylation through disrupting the interaction between TAB1 and p38, but it did not affect the mitogen-activated protein kinase 3/6 mediated p38 phosphorylation. In conclusion, the present study identifies MLB as an active component of Danshen in protecting cardiomyocytes from ischemic injury through specific inhibition of TAB1–p38 apoptosis signaling. These results indicate TAB1–p38 interaction as a putative drug target in treating ischemic heart diseases

Maize straw application as an interlayer improves organic carbon and total nitrogen concentrations in the soil profile: A four-year experiment in a saline soil

Soil salinization is a critical environmental issue restricting agricultural production. Deep return of straw to the soil as an interlayer (at 40 cm depth) has been a popular practice to alleviate salt stress. However, the legacy effects of straw added as an interlayer at different rates on soil organic carbon (SOC) and total nitrogen (TN) in saline soils still remain inconclusive. Therefore, a four-year (2015–2018) field experiment was conducted with four levels (i.e., 0, 6, 12 and 18 Mg ha–1) of straw returned as an interlayer. Compared with no straw interlayer (CK), straw addition increased SOC concentration by 14–32 and 11–57% in the 20–40 and 40–60 cm soil layers, respectively. The increases in soil TN concentration (8–22 and 6–34% in the 20–40 and 40–60 cm soil layers, respectively) were lower than that for SOC concentration, which led to increased soil C:N ratio in the 20–60 cm soil depth. Increases in SOC and TN concentrations in the 20–60 cm soil layer with straw addition led to a decrease in stratification ratios (0–20 cm:20–60 cm), which promoted uniform distributions of SOC and TN in the soil profile. Increases in SOC and TN concentrations were associated with soil salinity and moisture regulation and improved sunflower yield. Generally, compared with other treatments, the application of 12 Mg ha–1 straw had higher SOC, TN and C:N ratio, and lower soil stratification ratio in the 2015–2017 period. The results highlighted that legacy effects of straw application as an interlayer were maintained for at least four years, and demonstrated that deep soil straw application had a great potential for improving subsoil fertility in salt-affected soils.publishedVersio