2,360 research outputs found
The Chesapeake Bay: A Study of Present and Furture Water Quality and Its Ecological Effects Volume I: Analysis and Projection of Water Quality
This study, prepared for the National Commission on Water Quality, is an analysis of the present and future water quality in the Chesapeake Bay from the Susquehanna River at Conowingo, Md. to the Atlantic Ocean. The objectives addressed in this volume of the study are 1.) Description of the present conditions of water quality and water quantity with respect to temperature, salinity, nutrients and dissolved oxygen. and 2.) Projection of future water quality conditions associated with the achievement of require ments and goals of the Federal Water Pollution Control Act Amendments of 1972, P.L. 92-500, 86 Stat. 816. The assessment of present and future biological and ecol ogical conditions is addressed in Volume II
Modeling realistic Earth matter density for CP violation in neutrino oscillation
We examine the effect of a more realistic Earth matter density model which
takes into account of the local density variations along the baseline of a
possi ble 2100 km very long baseline neutrino oscillation experiment. Its
influence to the measurement of CP violation is investigated and a comparison
with the commonly used global density models made. Significant differences are
found in the comparison of the results of the different density models.Comment: 16 pages, 8 figure
An Analytic Variational Study of the Mass Spectrum in 2+1 Dimensional SU(3) Hamiltonian Lattice Gauge Theory
We calculate the masses of the lowest lying eigenstates of improved SU(2) and
SU(3) lattice gauge theory in 2+1 dimensions using an analytic variational
approach. The ground state is approximated by a one plaquette trial state and
mass gaps are calculated in the symmetric and antisymmetric sectors by
minimising over a suitable basis of rectangular states
Topological Photonics
Topology is revolutionizing photonics, bringing with it new theoretical
discoveries and a wealth of potential applications. This field was inspired by
the discovery of topological insulators, in which interfacial electrons
transport without dissipation even in the presence of impurities. Similarly,
new optical mirrors of different wave-vector space topologies have been
constructed to support new states of light propagating at their interfaces.
These novel waveguides allow light to flow around large imperfections without
back-reflection. The present review explains the underlying principles and
highlights the major findings in photonic crystals, coupled resonators,
metamaterials and quasicrystals.Comment: progress and review of an emerging field, 12 pages, 6 figures and 1
tabl
Study of and
The decays and have been
investigated with a sample of 225.2 million events collected with the
BESIII detector at the BEPCII collider. The branching fractions are
determined to be and . Distributions of the angle
between the proton or anti-neutron and the beam direction are well
described by the form , and we find
for and
for . Our branching-fraction
results suggest a large phase angle between the strong and electromagnetic
amplitudes describing the decay.Comment: 16 pages, 13 figures, the 2nd version, submitted to PR
Controlling Cherenkov angles with resonance transition radiation
Cherenkov radiation provides a valuable way to identify high energy particles
in a wide momentum range, through the relation between the particle velocity
and the Cherenkov angle. However, since the Cherenkov angle depends only on
material's permittivity, the material unavoidably sets a fundamental limit to
the momentum coverage and sensitivity of Cherenkov detectors. For example, Ring
Imaging Cherenkov detectors must employ materials transparent to the frequency
of interest as well as possessing permittivities close to unity to identify
particles in the multi GeV range, and thus are often limited to large gas
chambers. It would be extremely important albeit challenging to lift this
fundamental limit and control Cherenkov angles as preferred. Here we propose a
new mechanism that uses constructive interference of resonance transition
radiation from photonic crystals to generate both forward and backward
Cherenkov radiation. This mechanism can control Cherenkov angles in a flexible
way with high sensitivity to any desired range of velocities. Photonic crystals
thus overcome the severe material limit for Cherenkov detectors, enabling the
use of transparent materials with arbitrary values of permittivity, and provide
a promising option suited for identification of particles at high energy with
enhanced sensitivity.Comment: There are 16 pages and 4 figures for the manuscript. Supplementary
information with 18 pages and 5 figures, appended at the end of the file with
the manuscript. Source files in Word format converted to PDF. Submitted to
Nature Physic
Stochastic evolution of cosmological parameters in the early universe
We develop a stochastic formulation of cosmology in the early universe, after
considering the scatter in the redshift-apparent magnitude diagram in the early
epochs as an observational evidence for the non-deterministic evolution of
early universe. We consider the stochastic evolution of density parameter in
the early universe after the inflationary phase qualitatively, under the
assumption of fluctuating factor in the equation of state, in the
Fokker-Planck formalism. Since the scale factor for the universe depends on the
energy density, from the coupled Friedmann equations we calculated the two
variable probability distribution function assuming a flat space geometry.Comment: 10 page
A gene signature for post-infectious chronic fatigue syndrome
Background: At present, there are no clinically reliable disease markers for chronic fatigue syndrome. DNA chip microarray technology provides a method for examining the differential expression of mRNA from a large number of genes. Our hypothesis was that a gene expression signature, generated by microarray assays, could help identify genes which are dysregulated in patients with post-infectious CFS and so help identify biomarkers for the condition. Methods: Human genome-wide Affymetrix GeneChip arrays (39,000 transcripts derived from 33,000 gene sequences) were used to compare the levels of gene expression in the peripheral blood mononuclear cells of male patients with post-infectious chronic fatigue (n = 8) and male healthy control subjects (n = 7). Results: Patients and healthy subjects differed significantly in the level of expression of 366 genes. Analysis of the differentially expressed genes indicated functional implications in immune modulation, oxidative stress and apoptosis. Prototype biomarkers were identified on the basis of differential levels of gene expression and possible biological significance Conclusion: Differential expression of key genes identified in this study offer an insight into the possible mechanism of chronic fatigue following infection. The representative biomarkers identified in this research appear promising as potential biomarkers for diagnosis and treatment
Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation
The AKT/PKB kinase is a key signaling component of one of the most frequently activated pathways in cancer and is a major target of cancer drug development. Most studies have focused on its activation by Receptor Tyrosine Kinase (RTK) mediated Phosphatidylinositol-3-OH kinase (PI3K) activation or loss of Phosphatase and Tensin homolog (PTEN). We have uncovered that growth factors binding to RTKs lead to activation of a non-receptor tyrosine kinase, Ack1 (also known as ACK or TNK2), which directly phosphorylates AKT at an evolutionarily conserved tyrosine 176 in the kinase domain. Tyr176-phosphorylated AKT localizes to the plasma membrane and promotes Thr308/Ser473-phosphorylation leading to AKT activation. Mice expressing activated Ack1 specifically in the prostate exhibit AKT Tyr176-phosphorylation and develop murine prostatic intraepithelial neoplasia (mPINs). Further, expression levels of Tyr176-phosphorylated-AKT and Tyr284-phosphorylated-Ack1 were positively correlated with the severity of disease progression, and inversely correlated with the survival of breast cancer patients. Thus, RTK/Ack1/AKT pathway provides a novel target for drug discovery
- …