3 research outputs found
Silver-Mediated <i>N</i>‑Trifluoromethylation of Sulfoximines
An unprecedented approach to <i>N</i>-trifluoromethylations
of electron-rich nucleophilic sites following a radical pathway is
reported. Accordingly, various sulfoximines (19 examples) have been <i>N</i>-trifluoromethylated, providing previously unreported products
with satisfying functionality tolerance in moderate to good yields.
With a C–N bond length at the N–CF<sub>3</sub> moiety
of 1.341 Ă… the respective linkage is shorter than a traditional
C–N single bond and comparable with that of a C–N double
bond
Copper-Catalyzed <i>N</i>‑Cyanation of Sulfoximines by AIBN
The
direct copper-catalyzed <i>N</i>-cyanation of sulfoximines
was achieved by using AIBN as a safe cyanide source. It represents
a simple and environmentally benign procedure for the construction
of the N–CN bond. Furthermore, some <i>sec</i>-amines
can also be tolerated well under this procedure
Modular Synthesis of 1,2-Benzothiazines and 1,2-Benzothiazine 1‑Imines via Palladium-Catalyzed C–H/C–C Activation Reactions
In this study, a modular approach
toward cyclic sulfoximines
and
sulfondiimines via palladium-catalyzed intramolecular C–H/C-C
activation reactions was reported. Various 1,2-benzothiazines including
bicyclic, tricyclic, highly fused ones, ones of the seven-membered
ring, along with 1,2-benzothiazine 1-imines were accessed in good
yields. KIE experiment demonstrated that the C–H bond cleavage
at the position ortho to the sulfoximine group is
not the rate-determining step in the coupling reaction