Silver-Mediated <i>N</i>‑Trifluoromethylation
of Sulfoximines
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Abstract
An unprecedented approach to <i>N</i>-trifluoromethylations
of electron-rich nucleophilic sites following a radical pathway is
reported. Accordingly, various sulfoximines (19 examples) have been <i>N</i>-trifluoromethylated, providing previously unreported products
with satisfying functionality tolerance in moderate to good yields.
With a C–N bond length at the N–CF<sub>3</sub> moiety
of 1.341 Å the respective linkage is shorter than a traditional
C–N single bond and comparable with that of a C–N double
bond