Silver-Mediated <i>N</i>‑Trifluoromethylation of Sulfoximines

Abstract

An unprecedented approach to <i>N</i>-trifluoromethylations of electron-rich nucleophilic sites following a radical pathway is reported. Accordingly, various sulfoximines (19 examples) have been <i>N</i>-trifluoromethylated, providing previously unreported products with satisfying functionality tolerance in moderate to good yields. With a C–N bond length at the N–CF₃ moiety of 1.341 Å the respective linkage is shorter than a traditional C–N single bond and comparable with that of a C–N double bond