72 research outputs found

    Case-Aware Adversarial Training

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    The neural network (NN) becomes one of the most heated type of models in various signal processing applications. However, NNs are extremely vulnerable to adversarial examples (AEs). To defend AEs, adversarial training (AT) is believed to be the most effective method while due to the intensive computation, AT is limited to be applied in most applications. In this paper, to resolve the problem, we design a generic and efficient AT improvement scheme, namely case-aware adversarial training (CAT). Specifically, the intuition stems from the fact that a very limited part of informative samples can contribute to most of model performance. Alternatively, if only the most informative AEs are used in AT, we can lower the computation complexity of AT significantly as maintaining the defense effect. To achieve this, CAT achieves two breakthroughs. First, a method to estimate the information degree of adversarial examples is proposed for AE filtering. Second, to further enrich the information that the NN can obtain from AEs, CAT involves a weight estimation and class-level balancing based sampling strategy to increase the diversity of AT at each iteration. Extensive experiments show that CAT is faster than vanilla AT by up to 3x while achieving competitive defense effect

    Mechanical properties and microscopic characteristics of steel fiber coal gangue concrete

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    Incorporation of coal gangue in the concrete mixes can realize utilization of the solid waste and reduce extraction/use of natural aggregates. To improve the mechanical properties of coal gangue concrete, this paper studies use of steel fibre together with coal gangue coarse aggregate, coal gangue fine aggregate/sand in various concrete mixes. The effect of volume dosages of steel fibre and different levels of replacing nature coarse aggregate and river sand with coal gangue aggregates on concrete compressive strength was first investigated. Then, a design of experiment using orthogonal test was adopted to study concrete mixes with 3 factors, namely, coal gangue coarse aggregate, coal gangue sand and steel fibre, and each at 3 levels. Through multidimensional statistical data analysis of the test results, the primary and secondary factors and the optimal composition of the steel fibre reinforced coal gangue concrete were identified, and a grey prediction model for compressive strength of the concrete mixes established. The microstructural characteristics and failure mechanism of steel fiber reinforced coal gangue concrete was also studied and discussed

    miR-216b Post-Transcriptionally Downregulates Oncogene KRAS and Inhibits Cell Proliferation and Invasion in Clear Cell Renal Cell Carcinoma

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    Background/Aims: Increasing evidence has shown that miR-216b plays an important role in human cancer progression. However, little is known about the function of miR-216b in renal cell carcinoma. Methods: The expression levels of miR-216b in renal cell carcinoma tissues and cell lines were examined by qRT-PCR. The biological role of miR-216b in renal cell carcinoma proliferation and/or metastasis was examined in vitro and in vivo. The target of miR-216b was identified by a dual-luciferase reporter assay. The expression level of KRAS protein was measured by western blotting. Results: The expression of miR-216b was downregulated in clear cell renal cell carcinoma (ccRCC) cell lines and specimens compared to the adjacent normal tissues. Furthermore, miR-216b can bind to the 3’untranslated region (UTR) of KRAS and inhibit the expression of KRAS through translational repression. The in vitro study revealed that miR-216b attenuated ccRCC cell proliferation and invasion. Furthermore, in vivo study also showed that miR-216b suppressed tumor growth. MiR-216b exerted its tumor suppressor function through inhibiting the KRAS-related MAPK/ERK and PI3K/AKT pathways. Conclusion: Our findings provide, for the first time, significant clues regarding the role of miR-216b as a tumor suppressor by targeting KRAS in ccRCC
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