135 research outputs found
Activities and Role of School-Based Counselors in the US: A National Survey of American Counseling Association Members
This study was conducted to determine: how a US sample of American Counseling Association (ACA) affiliated school-based counselors viewed their role; the extent to which various activities were practiced; and, how demographic variables (e.g., work setting and professional identity) were related to both perceptions of role and practice. Participants (N = 249) completed the International Survey of School Counselors Activities-US (ISSA-US) online, which measured both perceptions of the appropriateness of 42 activities and whether these activities are reported to be enacted. US counselors had a broad definition of their role and showed a high degree of consensus regarding the appropriateness of activities. Grade level proved to be an important determinate of the level of enactment of both group counseling and college and career counseling. The implications for of these findings for redefining the role of school counselors in the US and for international comparative research are discussed
Restoration of Noradrenergic Function in Parkinson’s Disease Model Mice
Dysfunction of the central noradrenergic and dopaminergic systems is the primary neurobiological characteristic of Parkinson’s disease (PD). Importantly, neuronal loss in the locus coeruleus (LC) that occurs in early stages of PD may accelerate progressive loss of dopaminergic neurons. Therefore, restoring the activity and function of the deficient noradrenergic system may be an important therapeutic strategy for early PD. In the present study, the lentiviral constructions of transcription factors Phox2a/2b, Hand2 and Gata3, either alone or in combination, were microinjected into the LC region of the PD model VMAT2 Lo mice at 12 and 18 month age. Biochemical analysis showed that microinjection of lentiviral expression cassettes into the LC significantly increased mRNA levels of Phox2a, and Phox2b, which were accompanied by parallel increases of mRNA and proteins of dopamine β-hydroxylase (DBH) and tyrosine hydroxylase (TH) in the LC. Furthermore, there was considerable enhancement of DBH protein levels in the frontal cortex and hippocampus, as well as enhanced TH protein levels in the striatum and substantia nigra. Moreover, these manipulations profoundly increased norepinephrine and dopamine concentrations in the striatum, which was followed by a remarkable improvement of the spatial memory and locomotor behavior. These results reveal that over-expression of these transcription factors in the LC improves noradrenergic and dopaminergic activities and functions in this rodent model of PD. It provides the necessary groundwork for the development of gene therapies of PD, and expands our understanding of the link between the LC-norepinephrine and dopamine systems during the progression of PD
Exact solution and surface critical behaviour of open cyclic SOS lattice models
We consider the -state cyclic solid-on-solid lattice models under a class
of open boundary conditions. The integrable boundary face weights are obtained
by solving the reflection equations. Functional relations for the fused
transfer matrices are presented for both periodic and open boundary conditions.
The eigen-spectra of the unfused transfer matrix is obtained from the
functional relations using the analytic Bethe ansatz. For a special case of
crossing parameter , the finite-size corrections to the
eigen-spectra of the critical models are obtained, from which the corresponding
conformal dimensions follow. The calculation of the surface free energy away
from criticality yields two surface specific heat exponents,
and , where
coprime to . These results are in agreement with the scaling relations
and .Comment: 13 pages, LaTeX, to appear in J. Phys.
Observation of the Singly Cabibbo-Suppressed Decay
The singly Cabibbo-suppressed decay is observed for the first time with a statistical
significance of by using 4.5 fb of collision data
collected at center-of-mass energies between 4.600 and 4.699 GeV with the
BESIII detector at BEPCII. The absolute branching fraction of
is measured to be in a model-independent approach. This is
the first observation of a Cabibbo-suppressed decay involving
in the final state. The ratio of branching fractions between
and the Cabibbo-favored decay
is calculated to be , where with the
Cabibbo mixing angle. This ratio significantly deviates from and
provides important information for the understanding of nonfactorization
contributions in decays.Comment: 8 pages, 2 figure
Study of the doubly Cabibbo-suppressed decays and
Based on 7.33 fb of collision data collected at
center-of-mass energies between 4.128 and 4.226 GeV with the BESIII detector,
the experimental studies of the doubly Cabibbo-suppressed decays and are reported. We determine the
absolute branching fraction of to be
() . No
significant signal of is observed and the upper
limit on its decay branching fraction at 90\% confidence level is set to be
.Comment: 10 pages, 4 figures, 4 table
Updated measurements of the M1 transition with
Based on a data sample of events
collected with the BESIII detector at the BEPCII collider, the M1 transition
with is
studied, where is or
. The mass and width of the are
measured to be MeV/
and MeV, respectively. The
product branching fraction is determined to be . Using , we obtain the branching fraction of the
radiative transition to be , where the third uncertainty is due to the quoted
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