Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early marker for severe COVID-19

COVID-19 severity is associated with cytokine levels and lymphopenia, but the role of immune cell subsets is not well understood. Here the authors immunophenotype whole blood samples from 54 COVID-19 patients and find that the immature neutrophil-to-VD2 T-cell ratio is associated with severe COVID-19

Migrant workers with COVID-19: Recognizing the crucial role non-governmental organizations perform

10.1016/j.lanwpc.2021.100145The Lancet Regional Health - Western Pacific910014

D-dimer Levels for the Exclusion of Pulmonary Embolism: Making Sense of International Guideline Recommendations

Several international guidelines provide recommendations around the use of D-dimer testing for exclusion of pulmonary embolism (PE), including the appropriate D-dimer threshold (or cutoff), but there is no consensus amongst them. We briefly discuss guideline variation, performance characteristics and limitations of commercially available D-dimer assays in this setting, referencing the Clinical and Laboratory Standards Institute (CLSI) guidelines that recommend immunoassays with high sensitivity (≥97%) and negative predictive value (≥98%). While age-adjusted D-dimer and pre-test adjusted D-dimer is considered a safe strategy across predefined patient subgroups, clinicians need to recognise the different performance characteristics of D-dimer assays, to enable safe clinical decisions for their patients. Importantly, D-dimer values must be correlated not only to clinical findings, but also interpreted within the context of the accuracy and precision of the specific testing modality, adhering to manufacturer specifications that are approved by regulatory authorities

Severe Thrombocytopenia, Thrombosis and Anti-PF4 Antibody after Pfizer-BioNTech COVID-19 mRNA Vaccine Booster—Is It Vaccine-Induced Immune Thrombotic Thrombocytopenia?

10.3390/vaccines10122023Vaccines101

A Case of Parvovirus-Related Haemophagocytic Lymphohistiocytosis in a Patient with HbH Disease

Hemophagocytic lymphohistiocytosis (HLH) is rare and life-threatening medical emergency. Parvovirus infection is rarely associated with HLH. We report a case of parvovirus-related HLH in a patient with alpha thalassaemia (HbH disease). The patient responded well to a course of dexamethasone without the need of etoposide. Based on our literature search, this is the first case of parvovirus related HLH in a patient with HbH disease in the medical literature

COVID-19 mRNA vaccine-associated cerebral venous thrombosis: Rare adverse event or coincidence?

10.1002/ajh.26773AMERICAN JOURNAL OF HEMATOLOGY98

BNT162b2 mRNA SARS-CoV-2 vaccination does not cause upregulation of endothelial activation markers or hypercoagulability: A prospective, single-arm, longitudinal study

10.1002/ajh.26462AMERICAN JOURNAL OF HEMATOLOGY974E141-E14

Hypercoagulability, endotheliopathy, and inflammation approximating 1 year after recovery: Assessing the long-term outcomes in COVID-19 patients

10.1002/ajh.26575AMERICAN JOURNAL OF HEMATOLOGY977915-92