LANDSAT follow-on experiment: Gulf of Mexico menhaden and thread herring resources investigation

The author has identified the following significant results. The most significant achievement realized is the successful mapping of high probability fishing areas from LANDSAT MSS data for two Mississippi Sound missions

Effective Field Theory of Gravity: Leading Quantum Gravitational Corrections to Newtons and Coulombs Law

In this paper we consider general relativity and its combination with scalar quantum electrodynamics (QED) as an effective quantum field theory at energies well below the Planck scale. This enables us to compute the one-loop quantum corrections to the Newton and Coulomb potential induced by the combination of graviton and photon fluctuations. We derive the relevant Feynman rules and compute the nonanalytical contributions to the one-loop scattering matrix for charged scalars in the nonrelativistic limit. In particular, we derive the post-Newtonian corrections of order $Gm/\text c^2 r$ from general relativity and the genuine quantum corrections of order $G\hbar/\text c^3 r^2$.Comment: 14 pages, 12 figure

Instability of the Ekman Spiral with Applications to the Planetary Boundary Layers

Spiral boundary layer instability applied to planetary boundary layer

LANDSAT menhaden and thread herring resources investigation

The author has identified the following significant results. The most significant achievement is the successful charting of high probability fishing areas from LANDSAT MSS data

Multicanonical Parallel Tempering

We present a novel implementation of the parallel tempering Monte Carlo method in a multicanonical ensemble. Multicanonical weights are derived by a self-consistent iterative process using a Boltzmann inversion of global energy histograms. This procedure gives rise to a much broader overlap of thermodynamic-property histograms; fewer replicas are necessary in parallel tempering simulations, and the acceptance of trial swap moves can be made arbitrarily high. We demonstrate the usefulness of the method in the context of a grand-multicanonical ensemble, where we use multicanonical simulations in energy space with the addition of an unmodified chemical potential term in particle-number space. Several possible implementations are discussed, and the best choice is presented in the context of the liquid-gas phase transition of the Lennard-Jones fluid. A substantial decrease in the necessary number of replicas can be achieved through the proposed method, thereby providing a higher efficiency and the possibility of parallelization.Comment: 8 pages, 3 figure, accepted by J Chem Phy

Reciprocity questionnaire

This project is part of a collaborative project with the research group “Reciprocals across languages” led by Nick Evans. One goal of this project is to develop a typology of reciprocals. This questionnaire is designed to help field workers get an overview over the type of markers used in the expression of reciprocity in the language studied

FEASIBILITY OF A SHEEP COOPERATIVE FOR GRAZING LEAFY SPURGE

This report presents an economic feasibility study of a 5,000 head, cooperatively owned, sheep operation for leafy spurge control. The objectives were 1) determine the return on investment of the cooperative, 2) determine the proposed structure of the cooperative, and 3) ascertain the amount of capital investment required by members in the cooperative. Three sheep flock management alternatives were initially considered for the cooperative. These were 1) winter lambing, 2) spring lambing, and 3) fall lambing. The fall lambing scenario was determined to be infeasible because of logistics associated with gathering and transportation of pregnant ewes and lack of grazing pressure on leafy spurge throughout the grazing season. The total capital investment per ewe for the winter lambing scenario was more than the spring lambing scenario - - $301 and$216, respectively. The expected net income generated by the winter lambing scenario was negative. The minimum break-even lamb selling price or lambs sold per ewe for the winter lambing scenario was $84.10/cwt and 1.33, respectively. The spring lambing scenario returned$124,000 annually. The minimum breakeven lamb selling price or lambs sold per ewe for the spring lambing scenario was $59.51/cwt and 0.94, respectively. The expected return on investment (50% equity) for cooperative members with the spring lambing scenario, assuming a 50-acre leafy spurge infestation in a 100-acre pasture and new fence, was 16 percent (stocking rate of 1 ewe and lambs per acre of leafy spurge). While these returns are not a guarantee of success for the spring lambing alternative, they do provide an indication of the potential that such a cooperative may have.Leafy Spurge, Cooperative, Weed Control, Sheep Grazing, Economics, Farm Management, Resource /Energy Economics and Policy, Agribusiness,

Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities

SIRT1, a class III histone deacetylase, plays a critical role in regulating cancer cell growth, migration and invasion, which makes it a potential target for cancer therapeutics. In this study, we screened derivatives of several groups of natural products and identified a novel SIRT1 inhibitor JQ-101, a synthetic derivative of the polyprenylated acylphloroglucinol (PPAP) natural products, with an IC(50) for SIRT1 of 30 µM in vitro, with 5-fold higher activity for SIRT1 vs. SIRT2. Exposure of tumor cells to JQ-101 significantly enhanced acetylation of p53 and histone H4K16 at known sites of SIRT1 deacetylation, validating SIRT1 as its cellular target. JQ-101 suppressed cancer cell growth and survival by targeting SIRT1, and also exhibited selective cytotoxicity towards a panel of human tumor cell lines, while producing no toxicity in two normal human cell types at comparable concentrations. JQ-101 induced both apoptosis and cell senescence, and suppressed cancer cell invasion in vitro. In summary, we have identified JQ-101 as a new SIRT1 inhibitor which may have potential application in cancer treatment through its ability to induce tumor cell apoptosis and senescence and suppress cancer cell invasion.CA164245 - NCI NIH HHS; R01 CA101992 - NCI NIH HHS; R21 CA129046 - NCI NIH HHS; R21 CA141036 - NCI NIH HHS; P50 GM067041 - NIGMS NIH HHS; UL1RR025771 - NCRR NIH HHS; CA101992 - NCI NIH HHS; UL1 RR025771 - NCRR NIH HHS; GM-073855 - NIGMS NIH HHS; CA129046 - NCI NIH HHS; R21 CA164245 - NCI NIH HHS; GM-067041 - NIGMS NIH HHS; CA141036 - NCI NIH HHS; R01 GM073855 - NIGMS NIH HH

Social rules govern vocal competition in the barn owl

To resolve the share of limited resources, animals often compete through exchange of signals about their relative motivation to compete. When two competitors are similarly motivated, the resolution of conflicts may be achieved in the course of an interactive process. In barn owls, Tyto alba, in which siblings vocally compete during the prolonged absence of parents over access to the next delivered food item, we investigated what governs the decision to leave or enter a contest, and at which level. Siblings alternated periods during which one of the two individuals vocalized more than the other. Individuals followed turn-taking rules to interrupt each other and momentarily dominate the vocal competition. These social rules were weakly sensitive to hunger level and age hierarchy. Hence, the investment in a conflict is determined not only by need and resource-holding potential, but also by social interactions. The use of turn-taking rules governing individual vocal investment has rarely been shown in a competitive context. We hypothesized that these rules would allow individuals to remain alert to one another's motivation while maintaining the cost of vocalizing at the lowest level

Ribose supplementation alone or with elevated creatine does not preserve high energy nucleotides or cardiac function in the failing mouse heart

Background: Reduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy state. Ribose supplementation is thought to support both salvage and re-synthesis of adenine nucleotides by bypassing the rate-limiting step. We therefore tested whether ribose would be beneficial in chronic heart failure in control mice and in mice with elevated myocardial creatine due to overexpression of the creatine transporter (CrT-OE). Methods and Results: Four groups were studied: sham; myocardial infarction (MI); MI+ribose; MI+CrT-OE+ribose. In a pilot study, ribose given in drinking water was bioavailable, resulting in a two-fold increase in myocardial ribose-5-phosphate levels. However, 8 weeks post-surgery, total adenine nucleotide (TAN) pool was decreased to a similar amount (8–14%) in all infarcted groups irrespective of the treatment received. All infarcted groups also presented with a similar and substantial degree of left ventricular (LV) dysfunction (3-fold reduction in ejection fraction) and LV hypertrophy (32–47% increased mass). Ejection fraction closely correlated with infarct size independently of treatment (r2 = 0.63, p<0.0001), but did not correlate with myocardial creatine or TAN levels. Conclusion: Elevating myocardial ribose and creatine levels failed to maintain TAN pool or improve post-infarction LV remodeling and function. This suggests that ribose is not rate-limiting for purine nucleotide biosynthesis in the chronically failing mouse heart and that alternative strategies to preserve TAN pool should be investigated