Geschichte der drei wichtigsten Ritterorden des Mittelalters : Templer, Johanniter und Marianer, (oder Deutsche Herren)

von Karl Falkenstei

Drittes Bändchen. Von der Entdeckung Neuholland's (1616) bis zu Cook's erster Weltumseglung (1768-1771)

von Karl Falkenstei

Geschichte der geographischen Entdeckungsreisen

von Karl Falkenstei

Kiri tundmatule

Falkenstein, Konstantin Karl, 1801-1855, ajakirjanik, Dresdeni Kuningliku Raamatukogu ülembibliotekaarAutograafide kogumises

Zweites Bändchen. Von Christoph Columbo's Tode bis zu der Entdeckung von Neuholland oder des Festlandes von Australien

von Karl Falkenstei

Intravitreal Crystalline Drug Delivery for Intraocular Proliferation Diseases

This study demonstrated a new approach and novel opportunity for treatment of chronic and refractory chorioretinal diseases

Micelle formulation of hexadecyloxypropyl-cidofovir (HDP-CDV) as an intravitreal long-lasting delivery system

There still is an unmet need for a safe and sustained intravitreal drug delivery system. In this study we are proposing and characterizing a micelle based, clear-media intravitreal drug delivery system using the lipid derivatized nucleoside analog, hexadecyloxypropyl-cidofovir (HDP-CDV, CMX 001). HDP-CDV forms micelles in water and in vitreous supernatant with the critical micelle concentration of 19 μg/mL and 9 μg/mL, respectively at 37°C. The formed micelles had the average size of 274.7 nm and the Zeta potential of −47.1 mV. Drug release study in the excised rabbit vitreous showed a sustained release profile with a half-life of 2.7 days. The micelle formulation of HDP-CDV demonstrated a good safety profile in two animal species (rabbit and guinea pig) following intravitreal injection. The sustained efficacy was tested in a pretreatment study design and the drug potency was tested in an ongoing herpes simplex virus (HSV-1) retinitis model. The pretreatment studies using single intravitreal injection and later HSV-1 infection revealed at least 9 weeks of vitreous presence and therapeutic level of HDP-CDV, with 71% eyes protection from infection. The treatment study demonstrated that intravitreal administration halted active HSV-1 retinitis in 80% of the infected eyes while cidofovir (CDV) treatment failed to suppress active HSV-1 retinitis. In summary, lipid derivatized nucleoside analogs can be formulated as a micelle intravitreal injection and provides a sustained drug release in vitreous for chronic retinal diseases