Badges to Acknowledge Open Practices: A Simple, Low-Cost, Effective Method for Increasing Transparency

Beginning January 2014, Psychological Science gave authors the opportunity to signal open data and materials if they qualified for badges that accompanied published articles. Before badges, less than 3% of Psychological Science articles reported open data. After badges, 23% reported open data, with an accelerating trend; 39% reported open data in the first half of 2015, an increase of more than an order of magnitude from baseline. There was no change over time in the low rates of data sharing among comparison journals. Moreover, reporting openness does not guarantee openness. When badges were earned, reportedly available data were more likely to be actually available, correct, usable, and complete than when badges were not earned. Open materials also increased to a weaker degree, and there was more variability among comparison journals. Badges are simple, effective signals to promote open practices and improve preservation of data and materials by using independent repositories

Badges to Acknowledge Open Practices: A Simple, Low-Cost, Effective Method for Increasing Transparency

Beginning January 2014, Psychological Science gave authors the opportunity to signal open data and materials if they qualified for badges that accompanied published articles. Before badges, less than 3% of Psychological Science articles reported open data. After badges, 23% reported open data, with an accelerating trend; 39% reported open data in the first half of 2015, an increase of more than an order of magnitude from baseline. There was no change over time in the low rates of data sharing among comparison journals. Moreover, reporting openness does not guarantee openness. When badges were earned, reportedly available data were more likely to be actually available, correct, usable, and complete than when badges were not earned. Open materials also increased to a weaker degree, and there was more variability among comparison journals. Badges are simple, effective signals to promote open practices and improve preservation of data and materials by using independent repositories

Structure-activity relationship of carbon nitride dots in inhibiting Tau aggregation

Due to the numerous failed clinical trials of anti-amyloid drugs, microtubule associated protein tau (MAPT) now stands out as one of the most promising targets for AD therapy. In this study, we report for the first time the structure-dependent MAPT aggregation inhibition of carbon nitride dots (CNDs). CNDs have exhibited great promise as a potential treatment of Alzheimer's disease (AD) by inhibiting the aggregation of MAPT. In order to elucidate its structure-activity relationship, CNDs were separated via column chromatography and five fractions with different structures were obtained that were characterized by multiple spectroscopy methods. The increase of surface hydrophilic functional groups is consistent with the increase of polarity from fraction 1 to 5. Particle sizes (1–2 nm) and zeta potentials (∼-20 mV) are similar among five fractions. With the increase of polarity from fraction 1 to 5, their MAPT aggregation inhibition capacity was weakened. This suggests hydrophobic interactions between CNDs and MAPT, validated via molecular dynamics simulations. With a zebrafish blood-brain barrier (BBB) model, CNDs were observed to cross the BBB through passive diffusion. CNDs were also found to inhibit the generation of multiple reactive oxygen species, which is an important contributor to AD pathogenesis. [Display omitted

Actually available, correct, usable, and complete materials.

<p>Percentage of articles with materials reported available at an independent archive or personal website that were actually available, had correct materials, had usable materials, and had complete materials. Once <i>Psychological Science</i> started offering badges, some articles reported availability but did not earn a badge, and others reported availability and did earn a badge. These are represented separately. Total number of articles reported in data points. Underlying data (<a href="https://osf.io/8ds2g/" target="_blank">https://osf.io/8ds2g/</a>) and scripts (<a href="https://osf.io/f7kqr/" target="_blank">https://osf.io/f7kqr/</a>) to reproduce this figure are available on the Open Science Framework.</p

Article coding scheme.

<p>A visual illustration of the full coding scheme used to evaluate the availability of data and materials. This figure is available for download on the Open Science Framework at <a href="https://osf.io/kjsxv/" target="_blank">https://osf.io/kjsxv/</a>.</p