82 research outputs found
Measurement of the muon anti-neutrino double-differential cross section for quasi-elastic scattering on hydrocarbon at~ GeV
We present double-differential measurements of anti-neutrino quasi-elastic
scattering in the MINERvA detector. This study improves on a previous single
differential measurement by using updated reconstruction algorithms and
interaction models, and provides a complete description of observed muon
kinematics in the form of a double-differential cross section with respect to
muon transverse and longitudinal momentum. We include in our signal definition
zero-meson final states arising from multi-nucleon interactions and from
resonant pion production followed by pion absorption in the primary nucleus. We
find that model agreement is considerably improved by a model tuned to MINERvA
inclusive neutrino scattering data that incorporates nuclear effects such as
weak nuclear screening and two-particle, two-hole enhancements.Comment: 47 pages, 31 figure
Measurement of Total and Differential Cross Sections of Neutrino and Antineutrino Coherent Production on Carbon
Neutrino induced coherent charged pion production on nuclei,
, is a rare inelastic interaction in
which the four-momentum squared transfered to the nucleus is nearly zero,
leaving it intact. We identify such events in the scintillator of MINERvA by
reconstructing |t| from the final state pion and muon momenta and by removing
events with evidence of energetic nuclear recoil or production of other final
state particles. We measure the total neutrino and antineutrino cross sections
as a function of neutrino energy between 2 and 20 GeV and measure flux
integrated differential cross sections as a function of , and
. The dependence and equality of the neutrino and
anti-neutrino cross-sections at finite provide a confirmation of Adler's
PCAC hypothesis
Direct Measurement of Nuclear Dependence of Charged Current Quasielastic-like Neutrino Interactions using MINERvA
Charged-current interactions on carbon, iron, and lead with a
final state hadronic system of one or more protons with zero mesons are used to
investigate the influence of the nuclear environment on quasielastic-like
interactions. The transfered four-momentum squared to the target nucleus,
, is reconstructed based on the kinematics of the leading proton, and
differential cross sections versus and the cross-section ratios of iron,
lead and carbon to scintillator are measured for the first time in a single
experiment. The measurements show a dependence on atomic number. While the
quasielastic-like scattering on carbon is compatible with predictions, the
trends exhibited by scattering on iron and lead favor a prediction with
intranuclear rescattering of hadrons accounted for by a conventional particle
cascade treatment. These measurements help discriminate between different
models of both initial state nucleons and final state interactions used in the
neutrino oscillation experiments
Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery
Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens that do not depend on exogenous adjuvants for induction of immune responses. These are based on the concept of Immune Complex Mimics (ICM), structures that are formed between an oligomeric antigen and a monoclonal antibody (mAb) to that antigen. In this way, the roles of antigens and antibodies within the structure of immune complexes are reversed, so that a single monoclonal antibody, rather than polyclonal sera or expensive mAb cocktails can be used. We tested this approach in the context of Mycobacterium tuberculosis (MTB) infection by linking the highly immunogenic and potentially protective Ag85B with the oligomeric Acr (alpha crystallin, HspX) antigen. When combined with an anti-Acr monoclonal antibody, the fusion protein formed ICM which bound to C1q component of the complement system and were readily taken up by antigen-presenting cells in vitro. ICM induced a strong Th1/Th2 mixed type antibody response, which was comparable to cholera toxin adjuvanted antigen, but only moderate levels of T cell proliferation and IFN-γ secretion. Unfortunately, the systemic administration of ICM did not confer statistically significant protection against intranasal MTB challenge, although a small BCG-boosting effect was observed. We conclude that ICM are capable of inducing strong humoral responses to incorporated antigens and may be a suitable vaccination approach for pathogens other than MTB, where antibody-based immunity may play a more protective role
Search for multimessenger signals in NOvA coincident with LIGO/Virgo detections
Using the NOvA neutrino detectors, a broad search has been performed for any signal coincident with 28 gravitational wave events detected by the LIGO/Virgo Collaboration between September 2015 and July 2019. For all of these events, NOvA is sensitive to possible arrival of neutrinos and cosmic rays of GeV and higher energies. For five (seven) events in the NOvA Far (Near) Detector, timely public alerts from the LIGO/Virgo Collaboration allowed recording of MeV-scale events. No signal candidates were found
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