Complejo cultural y deportivo en el distrito de Villa Maria del Triunfo

El proyecto trata de un Complejo Cultural y Deportivo en el Distrito de Villa María del Triunfo, esto porque el distrito se ha visto en la necesidad de tener este tipo de espacios que promuevan el deporte y ayuden al desarrollo cultural y social para los pobladores del distrito donde se ubica y los distritos fronterizos, con ello también se quiere ayudar a mitigar la delincuencia que abunda en el distrito y brindarles un equipamiento de calidad a los jóvenes para que puedan desarrollar nuevas habilidades con las distintas actividades que se plantean y poder otorgarles hábitos sanos y una mejor calidad de vida para su desarrollo como persona de bien

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly