New 4-Thiazolidinones of Nicotinic Acid with 2-Amino-6-methylbenzothiazole and their Biological Activity

The title compounds 6a–j, 2-[(6-methyl-1,3-benzothiazol-2-yl)amino]-N-[2-(substituted phenyl/furan-2-yl)-4-oxo-1,3-thiazolidin-3-yl]nicotinamides, were prepared from 2-chloropyridine-3-carboxylic acid (1) and 2-amino-6-methyl-benzothiazole (2) by known methods. All the compounds have been established by IR, 1H NMR, 13C NMR and elemental analyses. The in vitro antimicrobial screening of the compounds were carried out against two Gram positive (S. aureus, S. pyogenes), two Gram negative (E. coli, P. aeruginosa) bacteria and three fungal species (C. albicans, A. niger, A. clavatus) using the broth microdilution method. Some of the compounds are comparable with standard drugs

Synthesis of 2-pyrazolines from pyridine based chalcone by conventional and microwave techniques: Their comparison and antimicrobial studies

2-Pyrazolines from pyridine based chalcones by conventional and microwave techniques have been synthesized and their antimicrobial activity as well as a comparison study between conventional and microwave techniques has been done. Antimicrobial activity was carried out according to the broth micro dilution method and it was observed that compound 2d was found to be most active against gram negative bacteria and fungus Candida albicans. Microwave technique has been found superior over the conventional method in view of reaction time and energy requirement. Compounds have been characterized by 1H NMR, 13C NMR, IR and Mass spectral analyses