23 research outputs found
Effects of isoquinoline alkaloids from Macleaya cordata on physiological, immunological and inflammatory parameters in dogs
Get PDFImpact of the DRG-based reimbursement system on patient care and professional practise: perspectives of Swiss hospital physicians
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Impact of the DRG-based reimbursement system on patient care and professional practise: perspectives of Swiss hospital physicians
No full textDeep Sequencing Reveals Transient Segregation of T Cell Repertoires in Splenic T Cell Zones during an Immune Response
No full textDeep Sequencing Reveals Transient Segregation of T Cell Repertoires in Splenic T Cell Zones during an Immune Response
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P1232: PRINCIPLES OF PRECISION ONCOLOGY IN PRIMARY REFRACTORY HIGH-GRADE B-CELL LYMPHOMA WITH MYC-, BCL2 AND/OR BCL6 REARRANGEMENTS (HGBL-DH/TH)
No full textLocalization of MLH3 at the centrosomes.
Get PDFMutations in human DNA mismatch repair (MMR) genes are commonly associated with hereditary nonpolyposis colorectal cancer (HNPCC). MLH1 protein heterodimerizes with PMS2, PMS1, and MLH3 to form MutLα, MutLβ, and MutLγ, respectively. We reported recently stable expression of GFP-linked MLH3 in human cell lines. Monitoring these cell lines during the cell cycle using live cell imaging combined with confocal microscopy, we detected accumulation of MLH3 at the centrosomes. Fluorescence recovery after photobleaching (FRAP) revealed high mobility and fast exchange rates at the centrosomes as it has been reported for other DNA repair proteins. MLH3 may have a role in combination with other repair proteins in the control of centrosome numbers
Mensch-Maschine-Kommunikation in der Produktion - eine systematische Vorgehensweise zur Gestaltung von Programmiersystemen an CNC-Werkzeugmaschinen
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