49 research outputs found
Clip readjustment in aneurysm surgery after flow evaluation using the ultrasonic perivascular probe: case report
Onyx embolization for dural arteriovenous fistulas:a multi-institutional study
BACKGROUND: Although the liquid embolic agent, Onyx, is often the preferred embolic treatment for cerebral dural arteriovenous fistulas (DAVFs), there have only been a limited number of single-center studies to evaluate its performance. OBJECTIVE: To carry out a multicenter study to determine the predictors of complications, obliteration, and functional outcomes associated with primary Onyx embolization of DAVFs. METHODS: From the Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR) database, we identified patients who were treated for DAVF with Onyx-only embolization as the primary treatment between 2000 and 2013. Obliteration rate after initial embolization was determined based on the final angiographic run. Factors predictive of complete obliteration, complications, and functional independence were evaluated with multivariate logistic regression models. RESULTS: A total 146 patients with DAVFs were primarily embolized with Onyx. Mean follow-up was 29 months (range 0-129 months). Complete obliteration was achieved in 80 (55%) patients after initial embolization. Major cerebral complications occurred in six patients (4.1%). At last follow-up, 84% patients were functionally independent. Presence of flow symptoms, age over 65, presence of an occipital artery feeder, and preprocedural home anticoagulation use were predictive of non-obliteration. The transverse-sigmoid sinus junction location was associated with fewer complications, whereas the tentorial location was predictive of poor functional outcomes. CONCLUSIONS: In this multicenter study, we report satisfactory performance of Onyx as a primary DAVF embolic agent. The tentorium remains a more challenging location for DAVF embolization, whereas DAVFs located at the transverse-sigmoid sinus junction are associated with fewer complications
Flow Replacement Bypass for Aneurysms: Decision-Making Using Intraoperative Blood Flow Measurement
Purpose: There is much debate regarding the optimal strategy for extracranial-intracranial (EC-IC) bypass for complex aneurysms. We introduce the concept of a flow replacement bypass which aims to compensate for loss of flow in the efferent vessels of the aneurysm. The strategy to achieve this utilizes direct intraoperative flow measurements to guide optimal revascularization by matching graft flow to demand.
Methods: We reviewed all EC-IC bypass cases performed over a 6 year period. We identified cases in which intraoperative flow measurements using an ultrasonic flow probe were utilized to determine the revascularization strategy, and analyzed the decision-making paradigm. Results: Twenty three cases were analyzed. For terminal aneurysms, flow measurement in the affected vessel at baseline predicted the flow required for full replacement: MCA 50±25cc/min (n=9); PICA 13±7cc/min (n=4); PCA 33cc/min (n=1); SCA 10cc/min (n=1). For proximal ICA aneurysms (n=8), the flow deficit from baseline during carotid temporary occlusion was measured (26±18cc/min, an average of 44% drop from baseline). The adequacy of flow from the superficial temporal artery (STA) or occipital artery (OA), when available, was assessed prior to bypass, and STA, OA or vein interposition grafts were used accordingly. Measurement of bypass flow following anastomosis confirmed not only patency but sufficient flow in all cases: MCA 50±25cc/min, PICA 18±9cc/min, PCA 64cc/min, SCA 12 cc/min, ICA 36±25cc/min (STA) and >200cc/min (vein). Conclusions: Direct intraoperative measurement of flow deficit in aneurysm surgery requiring parent vessel sacrifice can guide the choice of flow replacement graft, and confirm the subsequent adequacy of bypass flow
Improved phase-contrast flow quantification by three-dimensional vessel localization
In this paper, a method of three-dimensional (3D) vessel localization is presented to allow the identification of a vessel of interest, the selection of a vessel segment, and the determination of a slice orientation to improve the accuracy of phase-contrast magnetic resonance (PCMR) angiography. A marching-cube surface-rendering algorithm was used to reconstruct the 3D vasculature. Surface-rendering was obtained using an iso-surface value determined from a maximum intensity projection (MIP) image. This 3D vasculature was used to find a vessel of interest, select a vessel segment, and to determine the slice orientation perpendicular to the vessel axis. Volumetric flow rate (VFR) was obtained in a phantom model and in vivo using 3D localization with double oblique cine PCMR scanning. PCMR flow measurements in the phantom showed 5.2% maximum error and a standard deviation of 9 mL/min during steady flow, 7.9% maximum error and a standard deviation of 13 mL/min during pulsatile flow compared with measurements using an ultrasonic transit-time flowmeter. PCMR VFR measurement error increased with misalignment at 10, 20, and 30 degrees oblique to the perpendicular slice in vitro and in vivo. The 3D localization technique allowed precise localization of the vessel of interest and optimal placement of the slice orientation for minimum error in flow measurements
A Bilateral Craniectomy Technique for In Vivo Photoacoustic Brain Imaging
Due to the high possibility of mechanical damage to the underlying tissues attached to the rat skull during a craniectomy, previously described methods for visualization of the rat brain in vivo are limited to unilateral craniotomies and small cranial windows, often measuring 4–5 mm. Here, we introduce a novel method for producing bilateral craniectomies that encompass frontal, parietal, and temporal bones via sequential thinning of the skull while preserving the dura. This procedure requires the removal of a portion of the temporalis muscle bilaterally, which adds an additional 2–3 mm exposure within the cranial opening. Therefore, while this surgery can be performed in vivo, it is strictly non-survival. By creating large, bilateral craniectomies, this methodology carries several key advantages, such as the opportunity afforded to test innovate imaging modalities that require a larger field of view and also the use of the contralateral hemisphere as a control for neurophysiological studies
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Effect of age on brain oxygenation regulation during changes in position.
IntroductionReports indicate that brain regulation of oxygenation is inhibited in patients with low baseline oxyhemoglobin concentrations and that brain oxyhemoglobin concentrations are decreased with aging. The purpose of this study was to determine if regulation of brain oxygenation to changes in blood pressure is inhibited by normal aging.MethodsBrain oxyhemoglobin (OHb) and deoxyhemoglobin (HHb) concentrations were determined from the forehead using a frequency domain near infrared spectroscopy in 27 healthy volunteers. Subjects were separated into two groups by age (20-39, n=16; 40-60, n=11). Brain hemoglobin and non-invasive blood pressure were measured in (1) supine, (2) sitting, (3) supine and (4) sitting positions with 10-min equilibration intervals between each determination. Statistical differences were determined by two way repeated measures analysis of variance.ResultsYoung subjects were 28+/-5 years (mean+/-S.D.) and older subjects were 48+/-6 years. In supine position, OHb and HHb were 28.4+/-8.3 and 15.4+/-2.4micromol/L, respectively, in young; 22.4+/-5.7 and 13.4+/-2.9micromol/L, respectively, in older subjects, both P<0.05 between groups. Changing position from supine to sitting decreased OHb 5% and increased HHb 5% with no difference between groups.ConclusionsThere was a small but significant decrease in OHb and an increase in HHb from supine to sitting position, and this effect was similar between young and older subjects. Regulation of brain oxygenation during modest decreases in blood pressure did not change in normal aging to 60 years compared to young adults
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Effect of age on brain oxygenation regulation during changes in position.
IntroductionReports indicate that brain regulation of oxygenation is inhibited in patients with low baseline oxyhemoglobin concentrations and that brain oxyhemoglobin concentrations are decreased with aging. The purpose of this study was to determine if regulation of brain oxygenation to changes in blood pressure is inhibited by normal aging.MethodsBrain oxyhemoglobin (OHb) and deoxyhemoglobin (HHb) concentrations were determined from the forehead using a frequency domain near infrared spectroscopy in 27 healthy volunteers. Subjects were separated into two groups by age (20-39, n=16; 40-60, n=11). Brain hemoglobin and non-invasive blood pressure were measured in (1) supine, (2) sitting, (3) supine and (4) sitting positions with 10-min equilibration intervals between each determination. Statistical differences were determined by two way repeated measures analysis of variance.ResultsYoung subjects were 28+/-5 years (mean+/-S.D.) and older subjects were 48+/-6 years. In supine position, OHb and HHb were 28.4+/-8.3 and 15.4+/-2.4micromol/L, respectively, in young; 22.4+/-5.7 and 13.4+/-2.9micromol/L, respectively, in older subjects, both P<0.05 between groups. Changing position from supine to sitting decreased OHb 5% and increased HHb 5% with no difference between groups.ConclusionsThere was a small but significant decrease in OHb and an increase in HHb from supine to sitting position, and this effect was similar between young and older subjects. Regulation of brain oxygenation during modest decreases in blood pressure did not change in normal aging to 60 years compared to young adults