Multi-scale folds/faults/fractures network characterization in the Saar-Lorraine coal basin

International audienc

A Single Mass Forming Colonic Primary Mantle Cell Lymphoma

Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin’s lymphoma (NHL) comprising around 7% of adult NHL. It is characterized by a chromosomal translocation t(11:14) and overexpression of Cyclin D1. The incidence of secondary gastrointestinal tract involvement in MCL ranges from 10 to 28% in various series. However primary gastrointestinal MCL is very rare, accounting for only 1 to 4% of primary gastrointestinal lymphomas. The most common endoscopic feature of primary intestinal MCL is multiple lymphomatous polyposis. In rare cases it presents as protruded lesions or superficial lesions. Single colonic mass presentation is an extremely infrequent presentation. MCL has an aggressive course with quick progression, and most cases are discovered in the advanced stages. Colonic biopsies with histologic examination and specific immunohistochemical staining are the gold standard for a proper diagnosis. We report a case of a single mass forming mantle cell lymphoma of the ascending colon in a 57-year-old female patient with unusual colonoscopic and radiologic features and describe the therapy the patient received, thereby adding to the spectrum of clinical presentations of this aggressive lymphoproliferative disorder

Total organic carbon evaluation of heterogeneous coaly facies using well logs data, Carboniferous Lorraine Basin (France)

International audienceTOTAL ORGANIC CARBON EVALUATION OF HETEROGENEOUS COALY FACIES USING WELL LOGS DATA, CARBONIFEROUS LORRAINE BASIN (FRANCE).Allouti S.1, Michels R.1, Izart A.1, Mombo-Mouketo M., Malartre F.1, Bartier D. 1, Géraud Y.1, Nassif F.21 Université de Lorraine, CNRS, GeoRessources lab, UMR7359, 54500 Vandœuvre-lès-Nancy, France 2 La Française de l’Energie, 57380 Pontpierre, France The last coal mine in Lorraine (France) closed down in 2004 due to the loss of French mines competitiveness. The amount of coal still buried in the Lorraine underground represent an important resource of coal bed methane. This type of resource is considered both as an unconventional reservoir and an alternative energy for France which contains a low carbon footprint. Currently a new exploration campaign is being carried out in the French part of Carboniferous basin and new data are available.The Saar-Lorraine Carboniferous Basin is about 300 km long and 20 km wide. The main part of the sedimentary filling consists of 5 km of fluvio-lacustrine deposits of the Westphalian in which the coal series develop. Westphalian strata are overlain by fluvial-dominated continental series of Stephanian in which coal is almost absent and finally a Permo-triassic cover of about 500 m thickness.There is an important interest in the Westphalian and Stephanian formations in the Saar-Lorraine basin as a potentially prospective coal bed methane. Coal, shale and coaly shale are the most prominent source rocks in the Lorraine basin. One key parameter to evaluate the potential gas generation is the total organic carbon content (TOC). There are well-known methods to estimate TOC in the laboratory such as carbon analyzers or Rock-Eval pyrolysis. However, sampling of the core or drill cuttings is very costly and the TOC estimated in this case is discontinuous along sedimentary profiles. To overcome this limitation, several methods are derived from well logs. In Saar-Lorraine basin well logs for analysis are readily available and some drilling cores avilable to provide samples to be analyzed as to calibrate the results from logging data.Recent publications describe methods of TOC determination by well-logs applied to marine clay deposits, yet application to continental coal bearing strata is much more scarce. A major problem to over-come is linked to the complexity of the sedimentary successions. The fluvial facies are dominant and characterized by fining upward depositional sequences which evolve from conglomerate to sandstone, silt, clay and sometimes coal. Thicknesses and extension in space of facies may vary significantly, due to local controlling factors. These were characterized by the study of facies sedimentology, depositional environment interpretation and genetic depositional sequence analysis using core data and well-log analysis. Two different TOC estimation techniques from well logs data, Δlog R (Passey et al., 1990) and Carbolog (Bessereau et al., 1991) were used within Techlog Schlumberger software with the aim to provide a best estimation for our continental fluvio-lacustrine coal bearing strata as well and coal bed methane reservoirs. These two methods rely on the response of well logs to organic matter using an overlay of sonic wave and resistivity logs. Furthermore, contrary to Carbolog, the application of Δlog R requires the determination of level of organic maturity (LOM) for each formation. LOM was determined using the correlation table proposed Hood at al. (1975) for vitrinite reflectance either measured by organic petrography or estimated from Rock-Eval Tmax values. This study is applied on three wells on the eastern part of the basin (Folschviller, Diebling and Johannsweiler) and three others on the western side (Saulcy, Lorettes and Chaumont ).Results show that there is high agreement between TOC estimated values using well logs and core measurements for sandstones. However, both Δlog R and Carbolog methods tend to underestimate TOC when compared to the available TOC measurements for coal, coaly shale and shale. It appears that the very large range of TOC values (from 0 to 100%) is a challenge in the application of the methods, especially when kerogen is very concentrated in coal seams.Objectives of this presentation will be to explain why TOC is underestimated for shales and coal seams, how to correct the calculated values and how this impacts the source-rock volumes estimates. It will also be presented how this information combined to facies analysis, depositional environment and genetic interpretation contributes to assess source-rock distribution in these very heterogenous sedimentary series. This work is part of the Regalor project: Coalbed Methane Resources in Lorraine for a low carbon energy. https://regalor.univ-lorraine.fr/en/regalor-2/References Bessereau, G., Carpentier B., and Huc A. Y.. (1991). Wireline Logging and Source Rocks-Estimation Of Organic Carbon Content By The Carbolog Method." The Log Analyst May-June, 279-297. Hood, A., Gutjahr C. C. M., and Heacock R. L.. (1975). Organic metamorphism and the generation of petroleum." AAPG bulletin 59.6 986-996.Passey, Q. R., Creaney S, Kulla J. B., Moretti F. J. and Stroud J. D. (1990). A practical model for organic richness from porosity and resistivity logs. AAPG bulletin 74, 1777-1794

Remplissage sédimentaire du bassin carbonifère sarro-lorrain : nouveaux forages, nouvelles données.

International audienceRemplissage sédimentaire du bassin carbonifère sarro-lorrain : nouveaux forages, nouvelles données.Salim Allouti ∗1, Metzger Mombo Mouketo1, Gireau Boumbouet1, Fabrice Malartre1, Raymond Michels1, Danièle Bartier1, Yves Géraud1, Marc Diraison1, Fady Nassif21 Université de Lorraine, CNRS, GeoRessources, UMR 7359 - France 2 La Française de l’Energie –FranceCe travail s'inscrit dans le projet "Ressources en Gaz de Lorraine" (REGALOR), un programme de recherche pluridisciplinaire Lorraine Université d'Excellence, Région Grand-Est, Feder.La dernière exploitation de charbon en Lorraine a fermé en 2004 pour des raisons associées à la perte de compétitivité des mines françaises. Les quantités de charbon encore enfouies dans le sous-sol lorrain constituent une ressource qui pourra être valorisée en exploitant le gaz de charbon. De nouvelles campagnes d'exploration ont été menées et de nouvelles données sont ainsi disponibles.Le bassin carbonifère sarro-lorrain s’étend sur environ 300km de long et 20km de large. Le remplissage est constitué de dépôts fluvio-lacustres du Westphalien où se développent les séries à charbon. Suivent ensuite, en discordance, les séries fluvio-lacustres du Stéphanien dans lesquelles le charbon est quasi-absent. Les dépôts permiens et triasiques reposent en discordance sur les séries carbonifères.A partir des nouvelles données, on cherche à améliorer la compréhension du modèle sédimentaire et de l’histoire thermique du bassin par (i) une étude de l’architecture sédimentaire en lien avec la variabilité des environnements de dépôts et (ii) par des analyses géochimiques de la matière organique et de la minéralogie des argiles. L'analyse sédimentologique couplée à l'étude des diagraphies permet de distinguer des associations de faciès reflétant le dépôt dans des systèmes alluviaux. Ainsi, on peut mettre en évidence des périodes caractérisées par la dominance des faciès conglomératiques en réponse à la création rapide d'accommodation par des failles extensives. Succède ensuite un arrangement stratigraphique de toutes les fractions granulométriques dans lesquelles s’expriment des couches de charbon et des argiles riches en charbon pendant les périodes de quiescence tectonique. Le cadre tectono-sédimentaire servira de support à une estimation de la répartition des roches-mères et à la reconstruction de l’histoire diagénétique. Suivra une estimation expérimentale du potentiel pétrolier des roches mères. L’ensemble des données conduira, à terme, à estimer la ressource en gaz du bassin.Mots-Clés : Carbonifère, bassin sarro-lorrain, charbon, histoire diagénétique, potentiel pétrolier, environnement de dépô

Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

© 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 licenseBackground: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the effect of disease stage and complications on postoperative mortality. Methods: This was a multicentre, international prospective cohort study of consecutive adult patients undergoing surgery for primary breast, colorectal, or gastric cancer requiring a skin incision done under general or neuraxial anaesthesia. The primary outcome was death or major complication within 30 days of surgery. Multilevel logistic regression determined relationships within three-level nested models of patients within hospitals and countries. Hospital-level infrastructure effects were explored with three-way mediation analyses. This study was registered with ClinicalTrials.gov, NCT03471494. Findings: Between April 1, 2018, and Jan 31, 2019, we enrolled 15 958 patients from 428 hospitals in 82 countries (high income 9106 patients, 31 countries; upper-middle income 2721 patients, 23 countries; or lower-middle income 4131 patients, 28 countries). Patients in LMICs presented with more advanced disease compared with patients in high-income countries. 30-day mortality was higher for gastric cancer in low-income or lower-middle-income countries (adjusted odds ratio 3·72, 95% CI 1·70–8·16) and for colorectal cancer in low-income or lower-middle-income countries (4·59, 2·39–8·80) and upper-middle-income countries (2·06, 1·11–3·83). No difference in 30-day mortality was seen in breast cancer. The proportion of patients who died after a major complication was greatest in low-income or lower-middle-income countries (6·15, 3·26–11·59) and upper-middle-income countries (3·89, 2·08–7·29). Postoperative death after complications was partly explained by patient factors (60%) and partly by hospital or country (40%). The absence of consistently available postoperative care facilities was associated with seven to 10 more deaths per 100 major complications in LMICs. Cancer stage alone explained little of the early variation in mortality or postoperative complications. Interpretation: Higher levels of mortality after cancer surgery in LMICs was not fully explained by later presentation of disease. The capacity to rescue patients from surgical complications is a tangible opportunity for meaningful intervention. Early death after cancer surgery might be reduced by policies focusing on strengthening perioperative care systems to detect and intervene in common complications. Funding: National Institute for Health Research Global Health Research Unit

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licenseBackground: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide. Methods: A multimethods analysis was performed as part of the GlobalSurg 3 study—a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital. Findings: Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3·85 [95% CI 2·58–5·75]; p<0·0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63·0% vs 82·7%; OR 0·35 [0·23–0·53]; p<0·0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer. Interpretation: Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised. Funding: National Institute for Health and Care Research