European Registry on Helicobacter pylori management (Hp-EuReg): Patterns and trends in first-line empirical eradication prescription and outcomes of 5 years and 21 533 patients

Objective The best approach for Helicobacter pylori management remains unclear. An audit process is essential to ensure clinical practice is aligned with best standards of care. Design International multicentre prospective non-interventional registry starting in 2013 aimed to evaluate the decisions and outcomes in H. pylori management by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap. Variables included demographics, previous eradication attempts, prescribed treatment, adverse events and outcomes. Data monitoring was performed to ensure data quality. Time-trend and geographical analyses were performed. Results 30 394 patients from 27 European countries were evaluated and 21 533 (78%) first-line empirical H. pylori treatments were included for analysis. Pretreatment resistance rates were 23% to clarithromycin, 32% to metronidazole and 13% to both. Triple therapy with amoxicillin and clarithromycin was most commonly prescribed (39%), achieving 81.5% modified intention-to-treat eradication rate. Over 90% eradication was obtained only with 10-day bismuth quadruple or 14-day concomitant treatments. Longer treatment duration, higher acid inhibition and compliance were associated with higher eradication rates. Time-trend analysis showed a region-dependent shift in prescriptions including abandoning triple therapies, using higher acid-inhibition and longer treatments, which was associated with an overall effectiveness increase (84%-90%). Conclusion Management of H. pylori infection by European gastroenterologists is heterogeneous, suboptimal and discrepant with current recommendations. Only quadruple therapies lasting at least 10 days are able to achieve over 90% eradication rates. European recommendations are being slowly and heterogeneously incorporated into routine clinical practice, which was associated with a corresponding increase in effectiveness

The role of statins on helicobacter pylori eradication: Results from the european registry on the management of h. pylori (hp-eureg)

Statins could increase the effectiveness of Helicobacter pylori eradication therapies due to their anti-inflammatory effect. The aim of this study was to analyze the impact of this therapeutic association in real life. This is a multicenter, prospective, non-interventional study aimed at evaluating the management of H. pylori by European gastroenterologists. Patients were registered in an e-CRF by AEG-REDCap from 2013 to 2020. The association between statin use and H. pylori eradication effectiveness was evaluated through multivariate analysis. Overall, 9988 and 705 patients received empirical and culture-guided treatment, respectively. Overall, statin use was associated with higher effectiveness in the empirical group (OR = 1.3; 95%CI = 1.1-1.5), but no association was found with first-line treatment effectiveness (N = 7738); as an exception, statin use was specifically associated with lower effectiveness of standard triple therapy (OR = 0.76; 95%CI = 0.59-0.99). In the rescue therapy empirical group (N = 2228), statins were associated with higher overall effectiveness (OR = 1.9; 95%CI = 1.4-2.6). However, sub-analyses by treatment schemes only confirmed this association for the single-capsule bismuth quadruple therapy (OR = 2.8; 95%CI = 1.3-5.7). No consistent association was found between statin use and H. pylori therapy effectiveness. Therefore, the addition of statins to the usual H. pylori treatment cannot be currently recommended to improve cure rates. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Features of the transmission of microwave signals at offshore facilities

Abstract In the article the capabilities of microwave signals transmission by fiber-optic communication lines on marine objects is considered. The features of constructing a scheme for transmitting a microwave signal from a passive antenna over a fiber-optic communication line are established. The technical solutions for optimizing the design of a fiber-optic communication line are proposed. The results of experimental investigations of fiber-optic communication lines parameters are presented.</jats:p

Features of the transmission of microwave signals in the range of 8–12 GHz in the maritime radar station over fiber-optic communication line

Abstract The presented work demonstrates a new design of a fiber-optic line of microwave signal transmission for the receiving path of the maritime radar station. The features of microwave signals transmission in the maritime radar station are established. New designs of the transmitting and receiving modules have been developed in view of the established features. The transmitting module is based on the Mach-Zehnder electro-optical modulator. The receiving module contains p-i-n diode that is based on heterostructures. The results of experimental studies are presented.</jats:p

Control of the mode composition of optical radiation in a microstructured fiber

Abstract The construction structure of microstructured fibers is considered. A research scheme of the mode composition and defects control in optical fibers is developed. A microstructured fiber for studying optical vortex fields has been developed and manufactured. The results of studies of the same fiber structure and the distribution of optical radiation depending on the parameters of the technological cycle of its production are presented.</jats:p

Features of construction of the scheme of fiber-optic communication system for transmission of analog signals in the frequency range from 0.135 to 40 GHz

Abstract The paper presents the design of a fiber-optic microwave signal transmission line. The use of the developed design of a fiber-optic microwave transmission line allows the radar operating frequency range to be at least doubled. In addition, the number of functional blocks is reduced to ensure the operation of the radar in this frequency range. The results of experimental studies are presented.</jats:p