Systematic Analysis of Carotenogenesis in Microalgae for Model-Based Process Design

Otto-von-Guericke-Universität Magdeburg, Fakultät für Verfahrens- und Systemtechnik, Dissertation, 2017von Dipl.-Ing. Melanie FachetLiteraturverzeichnis: Seite [145]-15

The cellular basis of the mechanism of action of cortisone acetate on contact sensitivity to oxazolone in the mouse.

The cellular aspects of the action of cortisone acetate on the induction and recall phases of contact sensitivity to oxazolone in the mouse have been investigated. The present findings indicate that cortisone has a much less damaging effect on the thymus-derived than on the non-thymus-derived lymphoid population in the peripheral lymphoid organs. It is also shown that the permanent immunosuppressive effect of cortisone given before sensitization is associated with the virtual absence of polymorph infiltration of the dermis, absence of epidermal vesication at the site of application of oxazolone and a considerable reduction in the amount of lymphocyte transformation amongst the thymus-derived cells in the draining lymph node. The temporary immunosuppression observed when cortisone is given just before recall is also associated with absence of polymorph infiltration of the dermis and of epidermal vesication at the test site. It is suggested that in the present model of cell-mediated immunity cortisone is immunosuppressive mainly by preventing the antigenic stimulus from being received. Some of the mechanisms by which cortisone could achieve this form of immunosuppression are discussed

Effect of corticosteroids and adult thymectomy on induction and recall of contact sensitivity in mice

The effect of cortisone acetate on specific cell mediated immunity in mice was investigated using contact sensitivity to oxazolone. A long-acting cortisone acetate preparation was found to be much more effective than a soluble preparation in suppressing temporarily the recall response to oxazolone. The long-acting preparation was also effective in inhibiting the induction of sensitivity when injected before (but not after) oxazolone. Removal of the thymus either before or after sensitization did not significantly enhance the effects of cortisone acetate, and it is therefore suggested that cortisone acetate acts independently of the thymus-derived lymphocyte population