Quantum radiation from superluminal refractive index perturbations

We analyze in detail photon production induced by a superluminal refractive index perturbation in realistic experimental operating conditions. The interaction between the refractive index perturbation and the quantum vacuum fluctuations of the electromagnetic field leads to the production of photon pairs.Comment: 4 page

A new modulation technique for high data rate low power UWB wireless optical communication in implantable biotelemetry systems

We report on the development of a novel modulation technique for UWB wireless optical communication systems for application in a transcutaneous biotelemetry. The solution, based on the generation of short laser pulses, allows for a high data rate link whilst achieving a significant power reduction (energy per bit) compared to the state-of-the-art. These features make this particularly suitable for emerging biomedical applications such as implantable neural/biosensor systems. The relatively simple architecture consists of a transmitter and receiver that can be integrated in a standard CMOS technology in a compact Silicon footprint. These parts include circuits for bias and drive current generation, conditioning and processing, optimised for low-volt age/low-power operation. Preliminary experimental findings validate the new paradigm and show good agreement with expected results. The complete system achieves a BER less than 10-7, with maximum data rate of 125Mbps and estimated total power consumption of less than 3mW

Spacetime geometries and light trapping in travelling refractive index perturbations

In the framework of transformation optics, we show that the propagation of a locally superluminal refractive index perturbation (RIP) in a Kerr medium can be described, in the eikonal approximation, by means of a stationary metric, which we prove to be of Gordon type. Under suitable hypotheses on the RIP, we obtain a stationary but not static metric, which is characterized by an ergosphere and by a peculiar behaviour of the geodesics, which are studied numerically, also accounting for material dispersion. Finally, the equation to be satisfied by an event horizon is also displayed and briefly discussed.Comment: 14 pages, 7 figure

Food Neophobia or Distrust of Novelties? Exploring consumers' attitudes toward GMOs, insects and cultured meat

The food industry is constantly challenged to find new ideas to satisfy the increasingly specific consumer demand. However, innovative food products do not always become part of consumption habits or create a market. One of the major sources of resistance to novelty lies in the attitude of the consumer, who in many cases may be suspicious or hostile as a result of specific ideologies, overly attached to tradition, or affected by neophobia. This paper analyzes the construct of food neophobia (the "unwillingness to try new foods") in its phenomenology and its actual power to explain hostility to innovation in the agri-food sector. The limits of the concept, which is not always sufficient to shed light on the many reasons that could underlie the rejection of certain foods, will also be discussed. In addition, we review the recent literature on Europeans' attitude toward novel foods and innovation including Genetically modified organisms (GMOs), cultivated meat and insects as food. This literature reveals a number of paradoxes in consumers' behavior, and in the many complex conditions underpinning the success of innovation in food production. These conditions can only be understood by reconstructing the meanings consumers assign to food, and are often embedded in larger social and political frameworks

Reply to Comment on: Hawking radiation from ultrashort laser pulse filaments

A comment by R. Schutzhold et al. raises possible concerns and questions regarding recent measurements of analogue Hawking radiation. We briefly reply to the opinions expressed in the comment and sustain that the origin of the radiation may be understood in terms of Hawking emission

Emission of correlated photon pairs from superluminal perturbations in dispersive media

We develop a perturbative theory that describes a superluminal refractive perturbation propagating in a dispersive medium and the subsequent excitation of the quantum vacuum zero-point fluctuations. We find a process similar to the anomalous Doppler effect: photons are emitted in correlated pairs and mainly within a Cerenkov-like cone, one on the forward and the other in backward directions. The number of photon pairs emitted from the perturbation increases strongly with the degree of superluminality and under realizable experimental conditions, it can reach up to ~0.01 photons per pulse. Moreover, it is in principle possible to engineer the host medium so as to modify the effective group refractive index. In the presence of "fast light" media, e.g. a with group index smaller than unity, a further ~10x enhancement may be achieved and the photon emission spectrum is characterized by two sharp peaks that, in future experiments would clearly identify the correlated emission of photon pairs.Comment: 9 pages, 7 figure

M-CSF regulates the cytoskeleton via recruitment of a multimeric signaling complex to c-Fms Tyr-559/697/721.

M-CSF is known to induce cytoskeletal reorganization in macrophages and osteoclasts by activation of phosphatidylinositol 3-kinase (PI3K) and c-Src, but the detailed mechanisms remain unclear. We find, unexpectedly, that tyrosine (Tyr) to phenylalanine (Phe) mutation of Tyr-721, the PI3K binding site in the M-CSF receptor c-Fms, fails to suppress cytoskeletal remodeling or actin ring formation. In contrast, mutation of c-Fms Tyr-559 to Phe blocks M-CSF-induced cytoskeletal reorganization by inhibiting formation of a Src Family Kinase SFK·c-Cbl·PI3K complex and the downstream activation of Vav3 and Rac, two key mediators of actin remodeling. Using an add-back approach in which specific Tyr residues are reinserted into c-Fms inactivated by the absence of all seven functionally important Tyr residues, we find that Tyr-559 is necessary but not sufficient to transduce M-CSF-dependent cytoskeletal reorganization. Furthermore, this same add-back approach identifies important roles for Tyr-697 and Tyr-721 in collaborating with Tyr-559 to recruit a multimeric signaling complex that can transduce signals from c-Fms to the actin cytoskeleton

Laser-assisted guiding of electric discharges around objects

Electric breakdown in air occurs for electric fields exceeding 34 kV/cm and results in a large current surge that propagates along unpredictable trajectories. Guiding such currents across specific paths in a controllable manner could allow protection against lightning strikes and high-voltage capacitor discharges. Such capabilities can be used for delivering charge to specific targets, for electronic jamming, or for applications associated with electric welding and machining. We show that judiciously shaped laser radiation can be effectively used to manipulate the discharge along a complex path and to produce electric discharges that unfold along a predefined trajectory. Remarkably, such laser-induced arcing can even circumvent an object that completely occludes the line of sight

Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin

The β3 integrin cytoplasmic domain, and specifically S752, is critical for integrin localization and osteoclast (OC) function. Because growth factors such as macrophage colony–stimulating factor and hepatocyte growth factor affect integrin activation and function via inside-out signaling, a process requiring the β integrin cytoplasmic tail, we examined the effect of these growth factors on OC precursors. To this end, we retrovirally expressed various β3 integrins with cytoplasmic tail mutations in β3-deficient OC precursors. We find that S752 in the β3 cytoplasmic tail is required for growth factor–induced integrin activation, cytoskeletal reorganization, and membrane protrusion, thereby affecting OC adhesion, migration, and bone resorption. The small GTPases Rho and Rac mediate cytoskeletal reorganization, and activation of each is defective in OC precursors lacking a functional β3 subunit. Activation of the upstream mediators c-Src and c-Cbl is also dependent on β3. Interestingly, although the FAK-related kinase Pyk2 interacts with c-Src and c-Cbl, its activation is not disrupted in the absence of functional β3. Instead, its activation is dependent upon intracellular calcium, and on the β2 integrin. Thus, the β3 cytoplasmic domain is responsible for activation of specific intracellular signals leading to cytoskeletal reorganization critical for OC function