Tirana: la nuova vita della Piramide di Hoxha

Se guardiamo oggi alla città, ci si trova davanti alla realtà di una capitale fatta di 111 anni, caratterizzata da una commistione di epoche e linguaggi (ottomano, italiano, realista-socialista e, negli ultimi anni, contemporaneo), accostati in una dimensione urbana contenuta, di circa 1.100 kmq e 900.000 abitanti, ancora organizzata prevalentemente attorno al centro storico con piazza Scanderbeg e alle direttrici viarie verso le città di Kavaja, Dibra e Durazzo. Tra frammenti di quartieri di origine ottomana e opere moderniste sopravvissute alla corsa verso il contemporaneo di una nazione in continua tensione tra sviluppo economico e salvaguardia della memoria, a definire le assialità della metropoli è ancora oggi il suo boulevard monumentale “Martiri della Nazione” (Bulevardi Dëshmorët e Kombit). Lungo 1.060 m, collega in direzione nord-sud la centrale piazza Scanderbeg fino all’ex Casa del Fascio, oggi sede dell’Università Politecnica. [...

Correction to: Spino-pelvic balance and surgical treatment of L5–S1 isthmic spondylolisthesis

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Safety and comfort of domestic bortezomib injection in real-life experience

Despite novel agents, multiple myeloma is still an incurable disease, especially for elderly and frail patients, who are difficult to manage for concomitant comorbidities as the therapeutic options are limited and the response to chemotherapy is often short. We report our evaluations upon safety and efficacy of domestic subcutaneous bortezomib in elderly and frail patients candidate to bortezomib-melphalan-prednisone (VMP) regimen. We confirmed that overall incidence of adverse events, including peripheral neuropathy, was low, and in no case required admission to emergency service, contributing to reduce the rate of therapy discontinuation. These results confirm the effectiveness and safety of subcutaneous bortezomib, in a real-life-experience, and define a new possibility of safe auto-administration in a comfortable domestic setting. We suggest that domestic treatment can significantly improve the quality of life of the patients, avoiding unnecessary transfer to the hospital without reducing treatment efficacy

Pegfilgrastim in primary prophylaxis of febrile neutropenia following frontline bendamustine plus rituximab treatment in patients with indolent non-Hodgkin lymphoma: a single center, real-life experience

In this prospective study, the impact of granulocyte colony-stimulating factors (G-2 CSF) administered during induction treatment with bendamustine plus rituximab for indolent non- Hodgkin Llymphoma (NHL) was evaluated by comparing patients who received secondary prophylaxis with filgrastim (control group) versus. patients who received pegfilgrastim as primary prophylaxis (peg-group). The primary endpoint was the incidence rate of febrile neutropenia (FN)- related chemotherapy disruptions (regarding dose-dense and/or dose-intensity of schedule). The Ssecondary endpoint included days of hospitalization due to FN, and G-CSF-related side effects (grade ≥3 WHO toxicity criteria) in each group

Current Concepts in the Biopsy of Musculoskeletal Tumors

In the management of bone and soft tissue tumors, accurate diagnosis, using a combination of clinical, radiographic, and histological data, is critical to optimize outcome. On occasion, diagnosis can be made by careful history, physical examination, and images alone. However, the ultimate diagnosis usually depends on histologic analysis by an experienced pathologist. Biopsy is a very important and complex surgery in the staging process. It must be done carefully, so as not to adversely affect the outcome. Technical considerations include proper location and orientation of the biopsy incision and meticulous hemostasis. It is necessary to obtain tissue for a histological diagnosis without spreading the tumor and so compromise the treatment. Furthermore, the surgeon does not open compartmental barriers, anatomic planes, joint space, and tissue area around neurovascular bundles. Nevertheless, avoid producing a hematoma. Biopsy should be carefully planned according to the site and definitive surgery and should be performed by an orthopedic surgeon with an experience in musculoskeletal oncology who will perform the definitive surgery. Improperly done, it can complicate patient care and sometimes even eliminate treatment options. Different biopsy techniques are suitable: fine-needle aspiration, core-needle biopsy, and incisional biopsy. The choice of biopsy depends on the size, the location of the lesion, and the experience of the pathologist

A Comparative Study of the X-Ray Afterglow Properties of Optically Bright and Dark Gamma-Ray Bursts

We have examined the complete set of X-ray afterglow observations of dark and optically bright gamma-ray bursts (GRBs) performed by BeppoSAX through 2001 February. X-ray afterglows are detected in ~90% of the cases. We do not find significant differences in the X-ray spectral shape, in particular no increased X-ray absorption in GRBs without optical transient (dark GRBs) compared to GRBs with optical transient (OTGRBs). Rather, we find that the 1.6-10 keV flux of OTGRBs is on average about 5 times larger than that of the dark GRBs. A Kolmogorov-Smirnov test shows that this difference is significant at 99.8% probability. Under the assumption that dark and OTGRBs have similar spectra, this could suggest that the first are uncaught in the optical band because they are just faint sources. In order to test this hypothesis, we have determined the optical-to-X-ray flux ratios of the sample. OTGRBs show a remarkably narrow distribution of flux ratios, which corresponds to an average optical-to-X-ray spectral index = 0.794 ? 0.054. We find that, while 75% of dark GRBs have flux ratio upper limits still consistent with those of OT GRBs, the remaining 25% are 4-10 times weaker in optical than in X-rays. The significance of this result is ?2.6 ?. If this subpopulation of dark GRBs were constituted by objects assimilable to OTGRBs, they should have shown optical fluxes higher than upper limits actually found. We discuss the possible causes of their behavior, including a possible occurrence in high-density clouds or origin at very high redshift and a connection with ancient, Population III stars