52 research outputs found
Homogenous Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles: Scope and Mechanistic Studies
Influence of the reaction conditions on the productivity and on the molecular weight of the polyketone obtained by the CO–ethene copolymerisation catalysed by [Pd(TsO)(H2O)(dppp)](TsO) in MeOH
The influence of the operating conditions on the productivity on the CO-ethene copolymerisation catalysed by the title complex used in combination with TsOH and on the average numerical molecular weight, the limiting viscosity number and the average viscosity molecular weight of the resulting polyketone has been studied. The productivity, LVN and over(M, Ě„)v pass through a maximum for a TsOH/Pd ratio = 6/1, whereas over(M, Ě„)n reaches a plateau and remains practically constant at higher acid concentration. They increase upon increasing the pressures of the monomers when employed in the ratio 1/1 as well as upon increasing the pressure of CO keeping constant the pressure of the other monomer; the productivity as well as over(M, Ě„)n increase, whereas the LVN and over(M, Ě„)v pass through a maximum upon increasing the pressure of ethene, keeping constant the pressure of CO. A power law rate equation for the productivity has been obtained. The productivity decreases whereas the molecular weights increase upon lowering the temperature; the productivity decreases upon increasing the reaction time, whereas the molecular weights are little influenced. The results are discussed in the light of the copolymerisation mechanism
PREVALENCE, INCIDENCE AND OBSTETRIC CARE IMPACTFOR WOMEN WITH URINARY INCONTINENCE IN EUROPE: ASYSTEMATIC AND QUALITATIVE REVIEW OF THE LITERATURE
Introduction and Aim of the Study: Urinary Incontinence (UI)
is a prevalent, bothersome and costly condition, affecting
primarily women. UI is not a lethal condition, but it deeply
affects a woman\u2019s quality of life. The issue of UI has been well documented and there are national and international networks
focusing on the condition. However there is a lack of systematic,
reliable and consistent data, particularly with regards to
certain sections of the female population. The aimof this study
was to carry out a systematic synthesis of the published
evidence about prevalence, incidence, obstetric care and
impact of economical and human burden for women with UI
in Europe.
Materials and Methods: Epidemiologic and interventional
studies were sought from MEDLINE via PubMed to identify
articles published in English, French, Spanish, German and
Italian between 2000 and September 30, 2009. Prevalence and
incidence of female UI in the European general population and
among pregnant and post-partum women were abstracted
into the developed standardized form in order to answer the
following three questions: 1. What are the incidence and
prevalence ofUrinary Incontinence inWomen in Europe and its
specific subtypes? 1a. How are incidence and prevalence
influenced by pregnancy and childbirth? 2. How do obstetric
factors impact on prevalence and incidence of UI in women
after delivery in Europe? 3. How does Female Urinary
Incontinence impact on economic and human burden in
Europe? Patient outcomes after different obstetric interventionswere
compared fromrandomized controlled clinical trials
(RCTs) and observational studies. The impact of female UI on
quality of Life and economical aspects were abstracted from
previous systematic reviews and meta-analyses, controlled
clinical trials and observational studies.
Results: One hundred thirty three publications were eligible
for the review. The prevalence of UI of any type in noninstitutionalised
women in Europe ranged from 14.10% up to
68.8%. The prevalence was higher with increasing age: any
degree of UI was reported by 6\u201330% of women aged 18\u201324 up
to 50\u201367% of 90-year-old ladies. The annual incidence of
female UI in Europe ranged from 2.9% up to 8.3%. Significant
risk factors for UI in pregnancy were maternal age 35 years
(HR 2.1; 95% CI 1.0\u20132.8), maternal initial body max index (HR
1.3; 95%CI 1.1\u20131.6), a family history positive for UI (HR 1.7; 95%
CI 1.3\u20132.2), and parity (OR 2.0; 95% CI 2.0\u20132.2). The prevalence
rates of UI \u2018\u2018at term\u2019\u2019 pregnancy in Europe ranged from 26% up
to 40.2%, with a remission rate 3months after childbirth up to
86.4%. The prevalence rates of post-partumUI at 3months after
childbirth ranged from 2.2% up to 15%. UI during pregnancy
represented a significant risk factor for the persistence of UI
after delivery (OR 3.71; 95% CI 1.95\u20137.06). The major obstetric
risk factor was the mode of delivery. The caesarean section
seemed to be more protective than vaginal delivery, but this
advantage disappeared after the second caesarean delivery (OR
0.47; 95% CI 0.04\u20135.69). Five RCTs focused on the impact of
antenatal Pelvic Floor Muscle Training (PFMT) on the improvement
of the continence status in women after childbirth.
Antenatal PFMT could be helpful in the post-partum UI
prevention in primiparous women without UI during pregnancy.
Evidence from population-based studies showed a great
impact of UI (mainly urge UI/Overactive bladder wet and
mixed UI) in several health related quality of life (HR-QoL)
domains such as anxiety and depression, sexual function
impairment, limitation of physical activity, loss of independent
living in elderly and overall impairment of QoL. Several
studies examined the economic burden of UI, highlighting the
significant impact of this condition on patients and society.
Interpretation of Results: A wide variation in the estimates of
the prevalence and incidence of female UI in Europewas found.
The age represents a significant risk factors. Although an
under-representation of elderly women, the highest rates of
prevalence were shown in this age group. But these findings
came from a few studies that formally tested whether the
estimates of prevalence in women of different ages were
different from each other statistically. The methods used to
collect data, as well as the way in which UI was identified,
contributed to the wide variability in findings. Studies of
incidence highlighted that UI often may be transient. Among
the many methods proposed to prevent postpartum UI,
episiotomy and PFMT were investigated. The results are
disappointing or limited.
Conclusions: There is still an evident heterogeneity in UI
definition, outcome measures, survey methods, validation
criteria that make impossible to compare data and to report
conclusive findings. There is a clear need to perform observational
and interventional studies in Europe in order to better
answer the above mentioned questions using homogeneous
and standardised criteria mainly for sampling and outcome
measurements
Tubular segment-specific biomarkers of nephrotoxicity in the rat.
Segment-specific localization of p-aminohippuric acid accumulation and glutamine synthetase activity along the
proximal tubule was investigated in kidneys of rats treated with segment-specific nephrotoxicants such as potassium
dichromate (pars convoluta) and hexachloro-1:3-butadiene (pars recta). Potassium dichromate and the highest dose
(200 mg/kg b.w.) of hexachloro-1:3-butadiene caused a significant, dose-dependent decrease of p-aminohippuric acid
uptake in the renal cortical slices 24 and 48 h after the treatment. In contrast, hexachloro-1:3-butadiene and only the
highest dose (40 mg/kg b.w.) of potassium dichromate, caused a significant dose-dependent decrease of glutamine
synthetase activity in the kidney beginning 24 h after treatment. Finally, potassium dichromate and the highest dose
(200 mg/kg b.w.) of hexachloro-1:3-butadiene (48 h after the treatment) caused a significant dose-dependent loss of
kidney protein content. The results suggest that p-aminohippuric acid accumulation is localized in the pars convoluta
and confirm that glutamine synthetase is in the pars recta of the rat proximal tubule. p-Aminohippuric acid uptake
impairment and glutamine synthetase activity loss caused by the highest doses of hexachloro-1:3-butadiene and
potassium dichromate, respectively, suggests that high doses of segment-specific chemicals may involve other portions
of the proximal tubule; in addition, the decrease of glutamine synthetase activity caused by potassium dichromate
may be related to the protein content loss
Management of periurethral granuloma following injection with dextranomer/hyaluronic acid copolymer for stress urinary incontinence
Description of a case of periurethral granuloma after the injection of dextranomer/hyaluronic acid copolymer for stress urinary incontinenc
INCIDENCE AND PREVALENCE OF URINARY INCONTINENCE IN WOMEN IN EUROPE: SYSTEMATIC REVISION OF THE LITERATURE
Long-term functional results and vitality of AMS800 artificial urinary sphincter
We assessed the long term functional results if AMS800 in male patients with stress urinary incontinenc
HOW ARE INCIDENCE AND PREVALENCE INFLUENCED BY PREGNANCY AND CHILDBIRTH? A SYSTEMATIC LITERATURE REVIEW
Prevalence, Incidence and Obstetric Factors' Impact on Female Urinary Incontinence in Europe: A Systematic Review.
Objectives: A systematic review of the published data on theprevalence, incidence and risk factors of female urinary incontinence(UI) and obstetric treatment of UI in Europe. DataSources: Epidemiologic studies were sought via PubMed toidentify articles published in English, French, Spanish, Germanand Italian between 2000 and September 30, 2010, inEurope. Results: The prevalence of UI ranged from 14.1 to68.8% and increased with increasing age. Significant risk factorsfor UI in pregnancy were maternal age 6 35 years andinitial body mass index, a family history of UI and parity. UIin women who delivered \u2018at term\u2019 ranged from 26 to 40.2%,with a remission rate of 3 months after childbirth of up to86.4%. Pelvic floor muscle training may help to prevent postpartumUI in primiparous women without UI during pregnancy.Conclusion: UI definition, outcome measures, surveymethods and validation criteria are still heterogeneous, andthus it is difficult to compare data and impossible to drawdefinite conclusions
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