Identifying Light-curve Signals with a Deep Learning Based Object Detection Algorithm. II. A General Light Curve Classification Framework

Vast amounts of astronomical photometric data are generated from various projects, requiring significant efforts to identify variable stars and other object classes. In light of this, a general, widely applicable classification framework would simplify the task of designing custom classifiers. We present a novel deep learning framework for classifying light curves using a weakly supervised object detection model. Our framework identifies the optimal windows for both light curves and power spectra automatically, and zooms in on their corresponding data. This allows for automatic feature extraction from both time and frequency domains, enabling our model to handle data across different scales and sampling intervals. We train our model on datasets obtained from both space-based and ground-based multi-band observations of variable stars and transients. We achieve an accuracy of 87% for combined variables and transient events, which is comparable to the performance of previous feature-based models. Our trained model can be utilized directly to other missions, such as ASAS-SN, without requiring any retraining or fine-tuning. To address known issues with miscalibrated predictive probabilities, we apply conformal prediction to generate robust predictive sets that guarantee true label coverage with a given probability. Additionally, we incorporate various anomaly detection algorithms to empower our model with the ability to identify out-of-distribution objects. Our framework is implemented in the Deep-LC toolkit, which is an open-source Python package hosted on Github and PyPI.Comment: 26 pages, 19 figures, 6 tables. Submitted to AAS Journal. Code is available on https://github.com/ckm3/Deep-L

Search for nearby Earth analogs I. 15 planet candidates found in PFS data

30 pages, 20 figures, 3 tables, accepted for publication in ApJSThe radial velocity (RV) method plays a major role in the discovery of nearby exoplanets. To efficiently find planet candidates from the data obtained in high-precision RV surveys, we apply a signal diagnostic framework to detect RV signals that are statistically significant, consistent in time, robust in the choice of noise models, and do not correlated with stellar activity. Based on the application of this approach to the survey data of the Planet Finder Spectrograph, we report 15 planet candidates located in 14 stellar systems. We find that the orbits of the planet candidates around HD 210193, 103949, 8326, and 71135 are consistent with temperate zones around these stars (where liquid water could exist on the surface). With periods of 7.76 and 15.14 days, respectively, the planet candidates around star HIP 54373 form a 1:2 resonance system. These discoveries demonstrate the feasibility of automated detection of exoplanets from large RV surveys, which may provide a complete sample of nearby Earth analogs.Peer reviewedFinal Accepted Versio

The test case of HD26965: difficulties disentangling weak Doppler signals from stellar activity

We report the discovery of a radial velocity signal that can be interpreted as a planetary-mass candidate orbiting the K dwarf HD26965, with an orbital period of 42.364$\pm$0.015 days, or alternatively, as the presence of residual, uncorrected rotational activity in the data. Observations include data from HIRES, PFS, CHIRON, and HARPS, where 1,111 measurements were made over 16 years. Our best solution for HD26965 $b$ is consistent with a super-Earth that has a minimum mass of 6.92$\pm$0.79 M$_{\oplus}$ orbiting at a distance of 0.215$\pm$0.008 AU from its host star. We have analyzed the correlation between spectral activity indicators and the radial velocities from each instrument, showing moderate correlations that we include in our model. From this analysis, we recover a $\sim$38 day signal, which matches some literature values of the stellar rotation period. However, from independent Mt. Wilson HK data for this star, we find evidence for a significant 42 day signal after subtraction of longer period magnetic cycles, casting doubt on the planetary hypothesis for this period. Although our statistical model strongly suggests that the 42-day signal is Doppler in origin, we conclude that the residual effects of stellar rotation are difficult to fully model and remove from this dataset, highlighting the difficulties to disentangle small planetary signals and photospheric noise, particularly when the orbital periods are close to the rotation period of the star. This study serves as an excellent test case for future works that aim to detect small planets orbiting `Sun-like' stars using radial velocity measurements.Comment: 16 pages, 10 figures, 13 tables, accepted for publication in A

Complex Propagation Patterns Characterize Human Cortical Activity during Slow-Wave Sleep

Cortical electrical activity during nonrapid eye movement (non-REM) sleep is dominated by slow-wave activity (SWA). At larger spatial scales (similar to 2-30 cm), investigated by scalp EEG recordings, SWA has been shown to propagate globally over wide cortical regions as traveling waves, which has been proposed to serve as a temporal framework for neural plasticity. However, whether SWA dynamics at finer spatial scales also reflects the orderly propagation has not previously been investigated in humans. To reveal the local, finer spatial scale (similar to 1-6 cm) patterns of SWA propagation during non-REM sleep, electrocorticographic (ECoG) recordings were conducted from subdurally implanted electrode grids and a nonlinear correlation technique [mutual information (MI)] was implemented. MI analysis revealed spatial maps of correlations between cortical areas demonstrating SWA propagation directions, speed, and association strength. Highest correlations, indicating significant coupling, were detected during the initial positive-going deflection of slow waves. SWA propagated predominantly between adjacent cortical areas, albeit spatial noncontinuities were also frequently observed. MI analysis further uncovered significant convergence and divergence patterns. Areas receiving the most convergent activity were similar to those with high divergence rate, while reciprocal and circular propagation of SWA was also frequent. We hypothesize that SWA is characterized by distinct attributes depending on the spatial scale observed. At larger spatial scales, the orderly SWA propagation dominates; at the finer scale of the ECoG recordings, non-REM sleep is characterized by complex SWA propagation patterns

MeThAL: Vers une macroanalyse du théâtre en alsacien

Plusieurs travaux abordent l’analyse de corpus dramatiques larges appuyée sur des méthodes quantitatives, suivant des approches assimilables à la « macroanalyse » de Jockers (2013). La Revue d’Historiographie du Théâtre (2017) offre une synthèse de ces recherches en France. Les travaux de Schöch (2017) sur le théâtre classique français ou de Fischer et al. (2015 ; 2017) et le projet QuaDramA (2016) sur le théâtre allemand sont aussi proches de nos questionnements. Ces analyses examinent généralement les principales traditions dramatiques européennes. En raison de l’absence d’un corpus numérique approprié, de telles analyses sont à ce jour impossibles pour le théâtre alsacien, une tradition en dialecte dans laquelle les genres populaires et humoristiques prédominent. Le projet MeThAL vise à créer un grand corpus de théâtre dialectal alsacien encodé selon les recommandations de la Text Encoding Initiative (TEI) et à le valoriser, constituant un premier pas vers une macroanalyse du théâtre alsacien. Nous couvrirons la période 1870-1940, incluant l’âge d’or du théâtre dialectal, autour de la fondation du Théâtre Alsacien de Strasbourg en 1898 (Wackenheim, 1997). Nous travaillons sur un fonds documentaire récemment numérisé par la Bibliothèque Nationale et Universitaire (BNU) de Strasbourg, à savoir, un ensemble représentatif de pièces de théâtre en alsacien, dont nous avons commencé l’océrisation et l’encodage TEI. L’énorme variation orthographique de l’alsacien requiert une normalisation orthographique qui présente, comme pour toute langue peu dotée, des défis spécifiques en Traitement automatique des langues (TAL). Ces défis soulignent des besoins imparfaitement couverts par les outils d’analyse textuelle existants, orientés prioritairement vers les langues majoritaires. Dans ce sens, le projet élargira les ressources du projet RESTAURE pour les langues régionales de France (Bernhard et al., 2019). Le corpus permettra d’aborder des questions en sociolinguistique diachronique de l’Alsace de façon quantitative et d’examiner dans quelle mesure ce corpus permet de documenter les pratiques sociolinguistiques des différentes époques qu’il reflète. L’encodage TEI permettra l’analyse d’aspects formels de la technique dramatique et leur progression au cours de l’action, comme le « dynamisme » des pièces selon les changements du nombre de personnages sur scène (Fischer et al., 2017). Nous voulons également examiner de possibles patrons d’interaction entre groupes de personnages selon leur âge, position sociale, sexe ou origine. Les premiers résultats du projet, initié fin 2019, sont librement accessibles. La plate-forme DraCor (Fischer et Börner, 2019) a accepté d’accueillir la collection, permettant une analyse première des pièces. Nous développerons postérieurement des analyses plus spécifiques au corpus ainsi qu’une interface d’exploration. Dix ans après le « Manifeste des Digital Humanities » (Dacos, 2010), quel type d'humanités numériques représente MeThAL ? Le projet nécessite l’interdisciplinarité (TAL, littérature, sociolinguistique, dialectologie) observée dans le manifeste ; ses résultats seraient impossibles sans l'apport de chaque discipline. Il se prête bien par ailleurs à l'intégration formation/recherche dans le cadre de notre master Technologies des langues. En même temps, le projet souligne, et veut répondre à, des limitations concernant les langues peu dotées et la production culturelle dans celles-ci : manque d’outils d'analyse, manque de corpus numériques exploitables. Finalement, le projet vise une ouverture au public, en complément aux ressources de la BNU, afin d'agir (cf. Dacos, 2010) « au-delà de la seule sphère académique »

Search for Nearby Earth Analogs. II. detection of five new planets, eight planet candidates, and confirmation of three planets around nine nearby M dwarfs

© 2020 The American Astronomical Society. This is an author-created, un-copyedited version of an article accepted for publication in Astrophysical Journal Supplement Series. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The definitive publisher authenticated version is available online at https://doi.org/10.3847/1538-4365/ab5e7c.Zechmeister et al. surveyed 38 nearby M dwarfs from 2000 to 2007 March with VLT2 and the Ultraviolet and Visual Echelle Spectrograph (UVES) spectrometer. These data have recently been reanalyzed, yielding a significant improvement in the Doppler velocity precision. Spurred by this, we have combined the UVES data with velocity sets from High Accuracy Radial velocity Planet Searcher, Magellan/Planet Finder Spectrograph, and Keck/High Resolution Echelle Spectrometer. Sixteen planet candidates have been uncovered orbiting nine M dwarfs. Five of them are new planets corresponding to radial velocity signals, which are not sensitive to the choice of noise models and are identified in multiple data sets over various time spans. Eight candidate planets require additional observation to be confirmed. We also confirm three previously reported planets. Among the new planets, GJ 180 d and GJ 229A c are super-Earths located in the conservative habitable zones of their host stars. We investigate their dynamical stability using the Monte Carlo approach and find both planetary orbits are robust to the gravitational perturbations of the companion planets. Due to their proximity to the Sun, the angular separation between the host stars and the potentially habitable planets in these two systems is 25 and 59 mas, respectively. They are thus good candidates for future direct imaging by James Webb Space Telescope and E-ELT. In addition, we find GJ 433 c, a cold super-Neptune belonging to an unexplored population of Neptune-like planets. With a separation of 0.″5 from its host star, GJ 433 c is probably the first realistic candidate for the direct imaging of cold Neptunes. A comprehensive survey of these planets is important for the studies of planet formation.Peer reviewedFinal Published versio

PEXO : a global modeling framework for nanosecond timing, microsecond astrometry, and μm/s radial velocities

54 pages, 2 tables, 19 figures, accepted for publication in ApJS, PEXO is available at https://github.com/phillippro/pexoThe ability to make independent detections of the signatures of exoplanets with complementary telescopes and instruments brings a new potential for robust identification of exoplanets and precision characterization. We introduce PEXO, a package for Precise EXOplanetology to facilitate the efficient modeling of timing, astrometry, and radial velocity data, which will benefit not only exoplanet science but also various astrophysical studies in general. PEXO is general enough to account for binary motion and stellar reflex motions induced by planetary companions and is precise enough to treat various relativistic effects both in the solar system and in the target system. We also model the post-Newtonian barycentric motion for future tests of general relativity in extrasolar systems. We benchmark PEXO with the pulsar timing package TEMPO2 and find that PEXO produces numerically similar results with timing precision of about 1 ns, space-based astrometry to a precision of 1{\mu}as, and radial velocity of 1 {\mu}m/s and improves on TEMPO2 for decade-long timing data of nearby targets, due to its consideration of third-order terms of Roemer delay. PEXO is able to avoid the bias introduced by decoupling the target system and the solar system and to account for the atmospheric effects which set a practical limit for ground-based radial velocities close to 1 cm/s. Considering the various caveats in barycentric correction and ancillary data required to realize cm/s modeling, we recommend the preservation of original observational data. The PEXO modeling package is available at GitHub (https://github.com/phillippro/pexo).Peer reviewe

Molecular targets for the protodynamic action of cis-urocanic acid in human bladder carcinoma cells

<p>Abstract</p> <p>Background</p> <p>cis-urocanic acid (cis-UCA) is an endogenous amino acid metabolite capable of transporting protons from the mildly acidic extracellular medium into the cell cytosol. The resulting intracellular acidification suppresses many cellular activities. The current study was aimed at characterizing the molecular mechanisms underlying cis-UCA-mediated cytotoxicity in cultured cancer cells.</p> <p>Methods</p> <p>5367 bladder carcinoma cells were left untreated or treated with cis-UCA. Cell death was assessed by measuring caspase-3 activity, mitochondrial membrane polarization, formation and release of cytoplasmic histone-associated DNA fragments, and cellular permeabilization. Cell viability and metabolic activity were monitored by colorimetric assays. Nuclear labelling was used to quantify the effects of cis-UCA on cell cycle. The activity of the ERK and JNK signalling pathways was studied by immunoblotting with specific antibodies. Phosphatase activity in cis-UCA-treated cells was determined by assay kits measuring absorbance resulting from the dephosphorylation of an artificial substrate. All statistical analyses were performed using the two-way Student's t-test (p < 0.05).</p> <p>Results</p> <p>Here we report that treatment of the 5637 human bladder carcinoma cells with 2% cis-UCA induces both apoptotic and necrotic cell death. In addition, metabolic activity of the 5637 cells is rapidly impaired, and the cells arrest in cell cycle in response to cis-UCA. Importantly, we show that cis-UCA promotes the ERK and JNK signalling pathways by efficiently inhibiting the activity of serine/threonine and tyrosine phosphatases.</p> <p>Conclusions</p> <p>Our studies elucidate how cis-UCA modulates several cellular processes, thereby inhibiting the proliferation and survival of bladder carcinoma cells. These anti-cancer effects make cis-UCA a potential candidate for the treatment of non-muscle invasive bladder carcinoma.</p