Adaptation and Evolution in a Gravitational Environment — A Theoretical Framework for the Limited Re-Generative Post- Natal Time Window of the Heart in Higher Vertebrates

In the complex interplay between organization of the living matter, natural selection and adaptation, mammals have evolved with limited or no re-generative capabilities of the heart after birth. The reasons for this apparent flaw is far from being understood, however, they are closely related to the concept of organization and allocation of resources in a hierarchically structured multi-cellular organism with an evolved system of transport and communication, such as the circulation of blood. In humans this flaw may not have been a problem for thousands of years until, in the twentieth century, the increase in life expectancy has given rise to diseases generally less frequent in the first three or four decades of life. Therefore, the significant increase in morbidity and mortality related to cardiovascular disease, seen mainly in Western countries in the last years, has brought to the foreground the problem of cardiac damage and of its repair. In order to develop new therapies for cardiovascular damage aimed at reawakening and, possibly, expanding the limited re-generative capabilities of the heart is necessary to reconsider the basic concept on adaptation and functional reserve allocation in complex organisms

Assessing the Impact of Agricultural Research: Data Requirements and Quality of Current Statistics in Europe

Assessing the impact of agricultural research on sustainability targets often implies to face two main issues: the complexity of the causal path, and the lack of appropriate data. In this paper, we discuss which data would be necessary to measure short- and long-term impacts in Europe, and suggest a set of indicators to evaluate their quality, exploiting both available metadata (qualitative indicator) and the evidence stemming from the data themselves (quantitative indicator based on missing values, temporal contiguity and outliers). An application is shown for a subset of variables. According to our results, qualitative and quantitative indicators often provide conflicting information

Assessing the impact of agricultural research: Data requirements and quality of current statistics in Europe

Assessing the impact of agricultural research on sustainability targets often implies to face two main issues: the complexity of the causal path, and the lack of appropriate data. In this paper, we discuss which data would be necessary to measure short- and long-term impacts in Europe, and suggest a set of indicators to evaluate their quality, exploiting both available metadata (qualitative indicator) and the evidence stemming from the data themselves (quantitative indicator based on missing values, temporal contiguity and outliers). An application is shown for a subset of variables. According to our results, qualitative and quantitative indicators often provide conflicting information

Thermally-Reconfigurable Quantum Photonic Circuits at Telecom Wavelength by Femtosecond Laser Micromachining

The importance of integrated quantum photonics in the telecom band resides on the possibility of interfacing with the optical network infrastructure developed for classical communications. In this framework, femtosecond laser written integrated photonic circuits, already assessed for quantum information experiments in the 800 nm wavelength range, have great potentials. In fact these circuits, written in glass, can be perfectly mode-matched at telecom wavelength to the in/out coupling fibers, which is a key requirement for a low-loss processing node in future quantum optical networks. In addition, for several applications quantum photonic devices will also need to be dynamically reconfigurable. Here we experimentally demonstrate the high performance of femtosecond laser written photonic circuits for quantum experiments in the telecom band and we show the use of thermal shifters, also fabricated by the same femtosecond laser, to accurately tune them. State-of-the-art manipulation of single and two-photon states is demonstrated, with fringe visibilities greater than 95%. This opens the way to the realization of reconfigurable quantum photonic circuits on this technological platform

3-D shear wave velocity model of the lithosphere below the Sardinia-Corsica continental block based on Rayleigh-wave phase velocities

Rayleigh-wave dispersion curves from both ambient noise and teleseismic events allow us to provide the first high-resolution 3-D shear wave velocity (VS) model of the crust and upper mantle below the Sardinia–Corsica microplate, an important continental block for understanding the evolution of the central-western Mediterranean. For a wide range of periods (from 3 to ∼30 s), the phase velocities of the study area are systematically higher than those measured within the Italian peninsula, in agreement with a colder geotherm. Relative and absolute variations in the VS allow us to detect a very heterogeneous upper crust down to 8 km, as opposed to a relatively homogeneous middle and lower crust. The isosurface at 4.1 km s−1 is consistent with a rather flat Moho at a depth of 28.0 ± 1.8 km (2σ). The lithospheric mantle is relatively cold, and we constrain the thermal lithosphere–asthenosphere boundary at ∼100 km. We find our estimate consistent with a continental geotherm based on a surface heat flow of 60 mW m−2. Our results suggest that most of the lithosphere endured the complex history of deformation experienced by the study area and imply, in general, that deep tectonic processes do not easily destabilize the deeper portion of the continental lithosphere, despite leaving a clear surface signature

Effects of valsartan treatment on indicators of cardiovascular damage in newly diagnosed hypertensive patients: A prospective, twelve-month, open-label, pilot study

AbstractBackground: Myocardial fibrosis and dysfunction can be detected in the early phases of organ damage associated with hypertension. Valsartan, an angiotensin-II receptor blocker, is efficacious in lowering blood pressure (BP) and reducing left ventricular mass in patients with hypertension. Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and procollagen type I carboxy-terminal propeptide (PICP) are correlated with organ damage in patients with overt congestive heart failure; however, few data are available in patients with hypertension.Objective: The aim of this study was to assess the effects of 12 months of valsartan treatment on echocardiographic measures and indices of organ damage (NT-proBNP and PICP) in newly diagnosed patients with hypertension.Methods: This was a prospective, open-label, single-center, exploratory study. Patients with newly diagnosed, previously untreated hypertension were treated for 12 months with valsartan 160 mg/d and compared with an equal number of healthy, untreated control subjects. Baseline and follow-up visits at 3, 6, and 12 months included physical examination, systolic BP (SBP) and diastolic BP (DBP) measurements, ECG, echocardiography, and NT-proBNP and PICP determination.Results: A total of 20 patients (mean [SD] age, 48.05 [7.29] years) were enrolled and compared with 20 healthy controls (age, 49-6 [6.95] years). Compared with baseline, valsartan was associated with reduced BP in the group with hypertension after 12 months of treatment (mean SBP, 150.05 [11.15] vs 120.00 [8.43] mm Hg, P < 0.001; DBP, 97.80 [8.36] vs 79-50 [4.26] mm Hg, P < 0.001). Compared with the control group, at baseline, the group with hypertension had significantly higher mean left ventricular mass index (LVMI) (119.88 [22.86] vs 87.31 [15.77] g/m2; P < 0.001), relative wall thickness (thickness/radius [h/r] ratio: 0.45 [0.08] vs 0.35 [0.07]; P = 0.001), and NT-proBNP (50.00 [32.01] vs 25.47 [9.69] pg/dL; P = 0.002). PICP was higher, but the difference was not statistically significant (46.10 [15.69] vs 37.50 [7.20] μg/L). After 12 months, treatment with valsartan was associated with significant reductions in all measured parameters compared with baseline (LVMI, 106.51 [17.12] g/m2, P = 0.004; h/r, 0.41 [0.07], P = 0.026; NT-proBNP, 22.55 [13.52] pg/dL, P = 0.001; PICP, 35.20 [9–19] μg/L, P < 0.008). At 12 months, patients with hypertension treated with valsartan achieved NT-proBNP and PICP levels not statistically different from those of the healthy controls (NT-proBNP, 22.55 [13–52] vs 25.24 [8.43] pg/dL; PICP, 35.20 [9.19] vs 36.90 [6.41] μg/L).Conclusion: Patients treated with valsartan for 12 months had significant reductions in BP, LVMI, and indices of subclinical organ damage (NT-proBNP and PICP) compared with baseline