4 research outputs found
Results of the INRICH pathway analysis.
- Author
- Adam Wright (370435)
- Alexander Chuchalin (3720049)
- Alexander S. Tiganov (3720055)
- Alexey Polonikov (210096)
- Andrea Hofmann (777237)
- Andrea Pfennig (423714)
- Andreas J. Forstner (3280866)
- Andreas Reif (161777)
- André Lacour (477965)
- Anna Maaser (3720025)
- Bertram Müller-Myhsok (33498)
- Catherine Laprise (94905)
- Cristiana Cruceanu (331387)
- Céline S. Reinbold (3720073)
- Elza Khusnutdinova (146583)
- Fabian Streit (3720028)
- Fabio Rivas (3720037)
- Fermin Mayoral (3720070)
- Franziska Degenhardt (429524)
- Galina Pantelejeva (3720061)
- Grant W. Montgomery (131518)
- Gulja Babadjanova (3720040)
- Gustavo Turecki (63744)
- Guy A. Rouleau (105556)
- Heide Fier (3720067)
- Helmut Vedder (3720052)
- James D. McKay (3720076)
- Jana Strohmaier (183209)
- Janice M. Fullerton (320844)
- Jens Treutlein (314986)
- Joanna Hauser (128032)
- Johannes Schumacher (3720034)
- Jolanta Lissowska (89931)
- Julian Hecker (758791)
- Jutta Kammerer-Ciernioch (3720022)
- Lilia I. Abramova (3720031)
- Lorena M. Schenk (3720043)
- Manolis Kogevinas (135763)
- Manuel Mattheisen (170228)
- Marcella Rietschel (128064)
- Maria Grigoroiu-Serbanescu (423722)
- Markus Leber (573362)
- Markus M. Nöthen (160934)
- Markus Schwarz (3151407)
- Martin Alda (331388)
- Martin Hautzinger (471465)
- Michael Bauer (115390)
- Neonila Szeszenia-Dabrowska (197819)
- Nicholas G. Martin (113568)
- Paul Brennan (63967)
- Per Hoffmann (429526)
- Peter R. Schofield (123807)
- Philip B. Mitchell (423708)
- Piotr M. Czerski (423686)
- Sandra Meier (573361)
- Sarah E. Medland (127141)
- Sascha B. Fischer (3720058)
- Scott D. Gordon (3720046)
- Stefan Herms (429525)
- Stephanie H. Witt (244441)
- Sugirthan Sivalingam (3720064)
- Susanne Lucae (214969)
- Susanne Moebus (15191)
- Sven Cichon (170294)
- Thomas G. Schulze (215428)
- Thomas W. Mühleisen (170222)
- Tim Becker (160910)
- Valery Krasnov (159118)
- Wolfgang Maier (128051)
- Publication venue
- Publication date
- Field of study
<p>Results of the INRICH pathway analysis are shown in bar plot format. The x-axis shows negative logarithmic enrichment p-values for all nominally associated pathways containing two and more genes prior to- (gray) and after- (blue) correction for multiple testing. The red horizontal line indicates a p-value of 0.05.</p
Results of the Ingenuity Pathway Analysis.
- Author
- Adam Wright (370435)
- Alexander Chuchalin (3720049)
- Alexander S. Tiganov (3720055)
- Alexey Polonikov (210096)
- Andrea Hofmann (777237)
- Andrea Pfennig (423714)
- Andreas J. Forstner (3280866)
- Andreas Reif (161777)
- André Lacour (477965)
- Anna Maaser (3720025)
- Bertram Müller-Myhsok (33498)
- Catherine Laprise (94905)
- Cristiana Cruceanu (331387)
- Céline S. Reinbold (3720073)
- Elza Khusnutdinova (146583)
- Fabian Streit (3720028)
- Fabio Rivas (3720037)
- Fermin Mayoral (3720070)
- Franziska Degenhardt (429524)
- Galina Pantelejeva (3720061)
- Grant W. Montgomery (131518)
- Gulja Babadjanova (3720040)
- Gustavo Turecki (63744)
- Guy A. Rouleau (105556)
- Heide Fier (3720067)
- Helmut Vedder (3720052)
- James D. McKay (3720076)
- Jana Strohmaier (183209)
- Janice M. Fullerton (320844)
- Jens Treutlein (314986)
- Joanna Hauser (128032)
- Johannes Schumacher (3720034)
- Jolanta Lissowska (89931)
- Julian Hecker (758791)
- Jutta Kammerer-Ciernioch (3720022)
- Lilia I. Abramova (3720031)
- Lorena M. Schenk (3720043)
- Manolis Kogevinas (135763)
- Manuel Mattheisen (170228)
- Marcella Rietschel (128064)
- Maria Grigoroiu-Serbanescu (423722)
- Markus Leber (573362)
- Markus M. Nöthen (160934)
- Markus Schwarz (3151407)
- Martin Alda (331388)
- Martin Hautzinger (471465)
- Michael Bauer (115390)
- Neonila Szeszenia-Dabrowska (197819)
- Nicholas G. Martin (113568)
- Paul Brennan (63967)
- Per Hoffmann (429526)
- Peter R. Schofield (123807)
- Philip B. Mitchell (423708)
- Piotr M. Czerski (423686)
- Sandra Meier (573361)
- Sarah E. Medland (127141)
- Sascha B. Fischer (3720058)
- Scott D. Gordon (3720046)
- Stefan Herms (429525)
- Stephanie H. Witt (244441)
- Sugirthan Sivalingam (3720064)
- Susanne Lucae (214969)
- Susanne Moebus (15191)
- Sven Cichon (170294)
- Thomas G. Schulze (215428)
- Thomas W. Mühleisen (170222)
- Tim Becker (160910)
- Valery Krasnov (159118)
- Wolfgang Maier (128051)
- Publication venue
- Publication date
- Field of study
<p>Results of the Ingenuity Pathway Analysis (IPA) are shown in bar plot format. The x-axis shows negative logarithmic enrichment p-values for all associated pathways containing two and more genes prior to- (gray) and after- (blue) Benjamini Hochberg correction for multiple testing. The red horizontal line indicates a p-value of 0.05.</p
IPA pathway synaptic long term potentiation.
- Author
- Adam Wright (370435)
- Alexander Chuchalin (3720049)
- Alexander S. Tiganov (3720055)
- Alexey Polonikov (210096)
- Andrea Hofmann (777237)
- Andrea Pfennig (423714)
- Andreas J. Forstner (3280866)
- Andreas Reif (161777)
- André Lacour (477965)
- Anna Maaser (3720025)
- Bertram Müller-Myhsok (33498)
- Catherine Laprise (94905)
- Cristiana Cruceanu (331387)
- Céline S. Reinbold (3720073)
- Elza Khusnutdinova (146583)
- Fabian Streit (3720028)
- Fabio Rivas (3720037)
- Fermin Mayoral (3720070)
- Franziska Degenhardt (429524)
- Galina Pantelejeva (3720061)
- Grant W. Montgomery (131518)
- Gulja Babadjanova (3720040)
- Gustavo Turecki (63744)
- Guy A. Rouleau (105556)
- Heide Fier (3720067)
- Helmut Vedder (3720052)
- James D. McKay (3720076)
- Jana Strohmaier (183209)
- Janice M. Fullerton (320844)
- Jens Treutlein (314986)
- Joanna Hauser (128032)
- Johannes Schumacher (3720034)
- Jolanta Lissowska (89931)
- Julian Hecker (758791)
- Jutta Kammerer-Ciernioch (3720022)
- Lilia I. Abramova (3720031)
- Lorena M. Schenk (3720043)
- Manolis Kogevinas (135763)
- Manuel Mattheisen (170228)
- Marcella Rietschel (128064)
- Maria Grigoroiu-Serbanescu (423722)
- Markus Leber (573362)
- Markus M. Nöthen (160934)
- Markus Schwarz (3151407)
- Martin Alda (331388)
- Martin Hautzinger (471465)
- Michael Bauer (115390)
- Neonila Szeszenia-Dabrowska (197819)
- Nicholas G. Martin (113568)
- Paul Brennan (63967)
- Per Hoffmann (429526)
- Peter R. Schofield (123807)
- Philip B. Mitchell (423708)
- Piotr M. Czerski (423686)
- Sandra Meier (573361)
- Sarah E. Medland (127141)
- Sascha B. Fischer (3720058)
- Scott D. Gordon (3720046)
- Stefan Herms (429525)
- Stephanie H. Witt (244441)
- Sugirthan Sivalingam (3720064)
- Susanne Lucae (214969)
- Susanne Moebus (15191)
- Sven Cichon (170294)
- Thomas G. Schulze (215428)
- Thomas W. Mühleisen (170222)
- Tim Becker (160910)
- Valery Krasnov (159118)
- Wolfgang Maier (128051)
- Publication venue
- Publication date
- Field of study
<p>Results of the Ingenuity pathway analysis (IPA) for the pathway “Synaptic Long Term Potentiation” are shown. Shared schizophrenia-bipolar disorder associated genes (<i>GRIN2A</i>, <i>GRM3</i>, <i>CACNA1C</i>) are highlighted in purple.</p
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
- Author
- Aarno Palotie (41342)
- Abraham Reichenberg (111006)
- Adam Savitz (2816050)
- Agnes A Steixner-Kumar (12556900)
- Agung Kusumawardhani (12556765)
- Aiden Corvin (221286)
- Alan R Sanders (12557083)
- Alessandra Frustaci (627712)
- Alessandro Bertolino (252850)
- Alessandro Serretti (127197)
- Alessia Fiorentino (337442)
- Alexander L Richards (12556639)
- Alice Braun (12464946)
- Alicia R Martin (12556807)
- Allen D Radant (12556855)
- Alp Ucok (12556933)
- Amanda L Neil (11362707)
- Amy Lynham (12556798)
- Ana Gonzalez-Pinto (3555599)
- Anders D Borglum (12557008)
- Andreas Forstner (8440308)
- Andres Metspalu (61760)
- Andrew J Pocklington (12557104)
- Andrew Mackinnon (194271)
- Andrew McIntosh (83234)
- Andrew McQuillin (82209)
- Andrey Khrunin (264236)
- Angele Consoli (12556699)
- Anil K Malhotra (8536308)
- Ann E Pulver (12556987)
- Ann Olincy (521692)
- Anna Gareeva (12557023)
- Anna K Kahler (12556750)
- Anna Rautanen (246408)
- Anna Waterreus (499361)
- Annette M Hartmann (12556741)
- Antonio F Pardinas (12556618)
- Antonio Julia (7437728)
- Antonio Rampino (562822)
- Arne Vaaler (525065)
- Ary Gadelha (291025)
- Assen Jablensky (176467)
- Atsushi Takahashi (128295)
- Ayman H Fanous (12557020)
- Bart PF Rutten (10260760)
- Beben Benyamin (75571)
- Behrooz Z Alizadeh (12556651)
- Bela Melegh (3999857)
- Benedicto Crespo-Facorro (757227)
- Benjamin M Neale (3809995)
- Bernard Lerer (188298)
- Bernhard T Baune (6568502)
- Bertram Muller-Myhsok (12556978)
- Bettina Konte (511722)
- Blanca Gutierrez (560875)
- Boris Chaumette (3924791)
- Bradley T Webb (12556936)
- Brandon K Wormley (12556945)
- Brian J Kelly (12556756)
- Brien P Riley (12557074)
- Brion S Maher (12556801)
- Bruce Turetsky (521701)
- Bruno Pfuhlmann (12556852)
- Bryan J Mowry (12557062)
- C Robert Cloninger (12556963)
- Carlos N Pato (12557071)
- Carmel M Loughland (12556795)
- Carmen Moreno (76007)
- Carol Harvey (9410305)
- Caroline Hayward (149856)
- Catherine A Sugar (12556912)
- Celso Arango (2937681)
- Charles Curtis (4634179)
- Charlotte A Dennison (12556627)
- Cherrie Galletly (4444402)
- Cheryl Roe (12556861)
- Chia-Yen Chen (489003)
- Chih-Min Liu (173117)
- Chikashi Terao (137128)
- Christian Benner (775884)
- Christina M Hultman (12557032)
- Christopher P Morley (12556822)
- Christos Pantelis (272264)
- Claudine Laurent-Levinson (12557047)
- Clement C Zai (3351386)
- Colm McDonald (12556813)
- Conrad Iyegbe (3129249)
- Cristiano Noto (519130)
- Dan Rujescu (109427)
- Daniel P Howrigan (12556747)
- Daniel R Weinberger (12557095)
- Danielle Posthuma (237783)
- David A Collier (12557017)
- David Braff (521682)
- David Castle (796181)
- David Cohen (133780)
- David Curtis (82224)
- David M Hougaard (12556969)
- David Porteous (150029)
- David St Clair (77620)
- Debby W Tsuang (12557002)
- Derek W Morris (12557059)
- Dheeraj Malhotra (246403)
- Diana O Perkins (12556849)
- Diego Quattrone (9960317)
- Dieter B Wildenauer (12557098)
- Digby Quested (82223)
- Dimitris Dikeos (665137)
- Ditte Demontis (469970)
- Dolores Malaspina (5082809)
- Dominique Campion (577036)
- Donald W Black (12556948)
- Douglas F Levinson (12557050)
- Douglas S Lehrer (12556780)
- Draga Toncheva (264197)
- Dragan M Svrakic (12556915)
- Eli A Stahl (12556999)
- Elisabet Vilella (526755)
- Elisabeth Stogmann (12556903)
- Elizabeth G Atkinson (12556642)
- Elliot S Gershon (12556714)
- Elvira Bramon (12037049)
- Elza Khusnutdinova (146583)
- Engilbert Sigurdsson (12556882)
- Enrico Domenici (128020)
- Eric FC Cheung (12556696)
- Eric Hahn (507071)
- Eric Strengman (155445)
- Erik G Jonsson (12557038)
- Erik Soderman (12556894)
- Esben Agerbo (95553)
- Espen Molden (3902095)
- Esther Molina (12556816)
- Evangelos Vassos (231278)
- Evelyn J Bromet (9610685)
- F Anthony O'Neill (12556837)
- Fabian Streit (3720028)
- Faith Dickerson (453082)
- Farooq Amin (12556660)
- Feng Zhu (685)
- Florence Thibaut (6174902)
- Frank Dudbridge (102283)
- Frank Koopmans (1710484)
- Frans A Henskens (12556744)
- Franziska Degenhardt (429524)
- Fritz Zimprich (12362)
- Gary Donohoe (503643)
- George Kirov (61612)
- George N Papadimitriou (12556846)
- Georgia Panagiotaropoulou (12556621)
- Georgios Voloudakis (7324955)
- Gerald Nestadt (476496)
- Gerard Muntane (12556825)
- Gerome Breen (15025)
- Gian Battista Tura (12556930)
- Giulio Genovese (120795)
- Giuseppe Blasi (252857)
- Giuseppe Ducci (5956292)
- Gregory A Light (12556789)
- Hai-Gwo Hwu (173156)
- Hailiang Huang (211727)
- Hakon Hakonarson (102913)
- Hana Kuzelov A-Ptackova (12556768)
- Hannelore Ehrenreich (315807)
- Helen J Stain (12556897)
- Helena Medeiros (244197)
- Henrik Walter (370898)
- Hon-Cheong So (236119)
- Hreinn Stefansson (160840)
- Igor Nenadic (429529)
- Ina Giegling (127175)
- Inez Myin-Germeys (283072)
- Inge Joa (2657689)
- Ingrid Agartz (378654)
- Ingrid Melle (207704)
- Jaana Suvisaari (364516)
- Jacob Gratten (3300798)
- Jacqueline Goldstein (12556723)
- Jacques Mallet (15098)
- Jakob Grove (478984)
- James A Knowles (12557044)
- James L Kennedy (9605274)
- James TR Walters (12557116)
- Jan Lubinski (59925)
- Janet C Harwood (12556633)
- Janet L Sobell (12556891)
- Janis Klovins (76934)
- Javier Costas (232327)
- Javier Gonzalez Penas (12556726)
- Jeffrey Lieberman (12556786)
- Jennifer L Moran (12556975)
- Jeremy M Silverman (12556993)
- Jian Yang (12136)
- Jian Zeng (182624)
- Jianjun Liu (28194)
- Jianxin Shi (90453)
- Jim van Os (114336)
- Jimmy Lee (446122)
- Jin P Szatkiewicz (12556921)
- Jing Qin Wu (7874423)
- Johan G Eriksson (4683706)
- John J McGrath (8674098)
- John Powell (237327)
- John Waddington (2903360)
- Jonas Bybjerg-Grauholm (2614411)
- Jonathan Pimm (82214)
- Jordan W Smoller (12556996)
- Jorge A Cervilla (12557014)
- Josef Frank (378047)
- Joseph D Buxbaum (12557011)
- Joshua L Roffman (12556864)
- Jouko Lonnqvist (12556792)
- Jubao Duan (802555)
- Judit Bene (725901)
- Juha Veijola (150307)
- Julia Kraft (12464949)
- Julia Sidorenko (3694489)
- Julian Roth (8494662)
- Julien Bryois (596234)
- Julio Bobes (4247548)
- Julio Sanjuan (5367512)
- Jurjen J Luykx (8536323)
- Kang Sim (335914)
- Kari Stefansson (26484)
- Keith H Nuechterlein (12556831)
- Kenneth L Davis (12556702)
- Kenneth S Kendler (12557110)
- Kieran C Murphy (12556828)
- Kimberley D Chambert (12556690)
- Koksal Alptekin (12556654)
- Kyoko Watanabe (5459522)
- Kyung Sue Hong (8912684)
- Larry J Seidman (12556873)
- Larry J Siever (12556879)
- Laura C Lazzeroni (12556771)
- Lavinia Athanasiu (721820)
- Liene Nikitina-Zake (264225)
- Lieuwe de Haan (51668)
- Lili Milani (73375)
- Lourdes Fananas (12556708)
- Lourdes Martorell (7044902)
- Lynn E DeLisi (12556705)
- Lynsey S Hall (12556630)
- Madeline Alexander (12556648)
- Manuel Arrojo (423188)
- Manuel Mattheisen (170228)
- Mara Parellada (839497)
- Marcella Rietschel (128064)
- Marcos Leite Santoro (12556870)
- Margarita Rivera (12557077)
- Margot Albus (613068)
- Maria Dolores Molto (12556819)
- Maria Helena Azevedo (12556663)
- Mariam Al Eissa (12556645)
- Marianna Giannitelli (12556717)
- Marie-Odile Krebs (365386)
- Marina Mitjans (3161019)
- Mark Adams (26421)
- Mark H Rapaport (12556858)
- Mark J Daly (4951582)
- Mark Weiser (699679)
- Markus M Nothen (12557065)
- Marquis P Vawter (10275221)
- Marta Di Forti (3129243)
- Martin Begemann (5840690)
- Masashi Ikeda (162465)
- Massimo Gennarelli (239868)
- Matthew C Keller (12556753)
- Matthias Rothermundt (111333)
- Matthijs Verhage (67658)
- Matti Pirinen (415109)
- Max Lam (9721179)
- Menachem Fromer (5560)
- Meram C Saka (12557080)
- Merete Nordentoft (51499)
- Miaoxin Li (614827)
- Micha Gawlik (12557026)
- Michael C O'Donovan (12557119)
- Michael Davidson (699678)
- Michael F Green (12556729)
- Michael Gill (195307)
- Michael J Gandal (12556966)
- Michael J Owen (12557113)
- Michele T Pato (12556981)
- Michiaki Kubo (128298)
- Milan Macek (264249)
- Ming T Tsuang (12557092)
- Minh Tam Ta Thi (12556924)
- Minsoo Kim (171626)
- Monica E Calkins (12556684)
- Muhammad Ayub (582672)
- Murray J Cairns (7874447)
- Mythily Subramaniam (446121)
- Nakao Iwata (139930)
- Nancy G Buccola (12556954)
- Naomi R Wray (9279302)
- Neal R Swerdlow (12556918)
- Nelson B Freimer (12556711)
- Niamh Louise O'Brien (12556834)
- Nicholas J Bass (12556669)
- Nicholas J Bray (12556951)
- Nigel M Williams (12556939)
- Nikolay Kondratiev (12556759)
- Nils Eiel Steen (6094235)
- Nora Skarabis (12556885)
- Ole A Andreassen (5243117)
- Ole Mors (128054)
- Oleksandr Frei (6451931)
- Olivier Guillin (665136)
- Olli Pietilainen (5482613)
- Oussama Kebir (365383)
- Pablo Gejman (191172)
- Pak C Sham (12557089)
- Panos Roussos (318249)
- Paola Giusti-Rodriguez (3247965)
- Patricia T Michie (7874432)
- Patrick F Sullivan (8730545)
- Patrik KE Magnusson (3624236)
- Paul A Tooney (7874444)
- Paulo R Menezes (12557056)
- Per Hoffmann (429526)
- Peter A Holmans (12557101)
- Peter F Buckley (12556678)
- Peter M Visscher (12557107)
- Petr Slominsky (12556888)
- Phil H Lee (12556774)
- Preben B Mortensen (10806924)
- Qingqin S Li (12557053)
- Quirino Cordeiro (807336)
- Randy L Buckner (12556681)
- Raquel E Gur (12556735)
- Raquelle Mesholam-Gately (9598502)
- Raymond CK Chan (12556693)
- Rebecca Lencer (12556783)
- Renata Pellegrino (773084)
- Rene S Kahn (12557041)
- Richard A Belliveau (12556672)
- Richard Bruggeman (144361)
- Richard E Straub (12556906)
- Robert Freedman (521686)
- Robert W McCarley (12556810)
- Robert Yolken (104171)
- Robin M Murray (7955585)
- Rodney J Scott (5531030)
- Rodrigo Affonseca Bressan (7504037)
- Roel A Ophoff (8573757)
- Rolf Adolfsson (210493)
- Ruben C Gur (12556738)
- Ruud van Winkel (422356)
- Safaa Saker-Delye (12556867)
- Sally Isabel Sharp (12556876)
- Sandra Meier (573361)
- Sang-Yun Oh (12556840)
- Sara A Paciga (12557068)
- Sara Marsal (258049)
- Sarah E Bergen (12556675)
- Sarah Tosato (12556927)
- Sathish Periyasamy (478304)
- Sena Karachanak-Yankova (9416013)
- Shengying Qin (165450)
- Shi-Heng Wang (378857)
- Shuhua Xu (190024)
- Sibylle G Schwab (12557086)
- Sigurdur Magnusson (12556636)
- Silvia Torretta (716952)
- Silviu A Bacanu (12556666)
- Sinan Guloksuz (394950)
- Sintia Iole Belangero (12557005)
- Siow Ann Chong (8308434)
- Sophie E Legge (12556777)
- Srdjan Djurovic (170173)
- Srihari Gopal (2816062)
- Stanley Catts (12556687)
- Stefan Herms (429525)
- Stefano Bonassi (136975)
- Stefano Landi (511647)
- Stephan Ripke (156076)
- Stephanie Godard (12556720)
- Stephanie H Witt (12556942)
- Stephen Faraone (6158600)
- Stephen J Glatt (12557029)
- Stephen R Marder (12556804)
- Steven A McCarroll (12556972)
- Steven E Hyman (12557035)
- Sung-Wan Kim (112587)
- Sven Cichon (170294)
- Svetlana Limborska (264231)
- Swapnil Awasthi (11788712)
- T Scott Stroup (12556909)
- Therese van Amelsvoort (348773)
- Thomas D Als (12556657)
- Thomas G Schulze (12556990)
- Thomas Werge (170258)
- Tian Ge (369096)
- Tiffany A Greenwood (12556732)
- Tiina Paunio (130281)
- Tim B Bigdeli (12556624)
- Timothy Dinan (3930755)
- Ting Qi (537915)
- Todd Lencz (52220)
- Tonu Esko (3310785)
- Tony Kam-Thong (647240)
- Tracey L Petryshen (12556984)
- Ulrich Schall (581039)
- Vahram Haroutunian (23823)
- Vaidutis Kucinskas (3415886)
- Valentina Escott-Price (577023)
- Valeria Mondelli (3129255)
- Vanessa Kiyomi Ota (12556843)
- Vassily Trubetskoy (12556615)
- Vaughan J Carr (6060533)
- Veikko Salomaa (62543)
- Vera A Morgan (7040525)
- Vera Golimbet (5890595)
- Vihra Milanova (12045332)
- Vishwajit Nimgaonkar (116849)
- Volker Arolt (161757)
- Wei Cheng (52808)
- Wei J Chen (12556960)
- Wei Zhou (24328)
- Weihua Yue (102491)
- Wen Zhang (7555)
- Wiepke Cahn (155467)
- William F Byerley (12556957)
- William S Stone (7352516)
- Wolfgang Maier (128051)
- Xin Yu (124814)
- Yang Wu (66682)
- Yoichiro Kamatani (140517)
- Yongyong Shi (102679)
- Zhida Xu (2023525)
- Zhiqiang Li (102723)
- Zita Ausrele Kucinskiene (12556762)
- Publication venue
- Publication date
- 08/04/2022
- Field of study
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies