Cyclic AMP signalling in pancreatic islets

Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in intracellular calcium concentrations, and by the incretin hormones (GLP-1 and GIP). cAMP is rapidly degraded in the pancreatic islet β-cell by various cyclic nucleotide phosphodiesterase (PDE) enzymes. Many steps involved in glucose-induced insulin secretion are modulated by cAMP, which is also important in regulating pancreatic islet β-cell differentiation, growth and survival. This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the β-cell

High temperature meson propagators with domain-wall quarks

We study the chiral properties of domain-wall quarks at high temperatures on an ensemble of quenched configurations. Low lying eigenmodes of the Dirac operator are calculated and used to check the extent to which the Atiyah-Singer index theorem is obeyed on lattices with finite $N_5$. We calculate the connected and disconnected screening propagators for the lowest mass scalar and pseudoscalar mesons in the sectors of different topological charge and note that they behave as expected. Separating out the would-be zero eigenmodes enables us to accurately estimate the disconnected propagators with far less effort than would be needed otherwise.Comment: LATTICE99(Finite Temperature and Density), 3 pages, 3 figure

Training within industry (TWI-JS ) program as a tool to improve work safety in the steel industry in Poland

Accidents at work related to the operation of technological machinery are recorded in the steel industry in Poland. A reduction of accidents is possible through the implementation of technical and organizational measures. As regards the elimination of hazards at workplaces, it is possible to apply the Training Within Industry (TWI) program. One of its modules, i.e., Safety (JS), is aimed at creating a safe workplace by the acquisition of the skills of identification and elimination of the causes of hazards leading to accidents. This article aims to present the possibilities of the use of the TWI-JS method to prevent accidents at work in the steel industry

Scalar resonances: scattering and production amplitudes

Scattering and production amplitudes involving scalar resonances are known, according to Watson's theorem, to share the same phase $\delta(s)$. We show that, at low energies, the production amplitude is fully determined by the combination of $\delta(s)$ with another phase $\omega(s)$, which describes intermediate two-meson propagation and is theoretically unambiguous. Our main result is a simple and almost model independent expression, which generalizes the usual $K$-matrix unitarization procedure and is suited to be used in analyses of production data involving scalar resonances.Comment: 10 pages, 4 figures. Minor changes, references added, version to appear in Phys. Rev.

Impact of Organizational Career Management Activities on Organizational Commitment of Early, Mid, and Late Stage Career Professionals

Organizational commitment continues to be studied by researchers and practitioners due to the presumed relationships with important organizational outcomes such as turnover, performance, and absenteeism. Organizations are challenged with identifying practices such as organizational career management activities that will reduce costs associated with low performance and high turnover while recognizing the diversity of their workforces as it relates to early, mid, and late stage career professionals. Understanding the needs and unique characteristics of early, mid, and late career stage professionals can better inform organizations’ decision to invest in organizational career management activities to enhance organizational commitment across all three career stages. In this study, the impact of the availability and utilization of organizational career management activities on organizational commitment is studied through the lens of Perceived Organizational Support Theory. Results indicate that the availability and utilization of organizational career management activities have a positive relationship with perceived organizational support and perceived organizational support has a positive relationship with affective, normative, and continuance organizational commitment. Organizational career management activities do not have a direct relationship with turnover intentions, however, implications of varying levels of affective, normative, and continuance commitment are discussed. Further, no difference was found between early, mid, and late stage career professionals contradicting previous studies and informing future studies

Authigenic analcite in the Golden Valley Formation southwestern North Dakota

Authigenic analcite constitutes up to about 60 percent of a massive, arksosic sandstone exposed on major buttes in the North Dakota Badlands. The analcite constitutes up to about 80 percent of a thin analcimolite bed at the top of the arkose unit. The analcite occurs as spherulites in the interstices of the arkose and as a cement in the analcimolite. Three types of spherulites are recognized: (1) spherulites with an internal radial structure; (2) spherulites with a massive center and a peripheral radial structure; and (3) spherulites lacking an internal radial structure or having a poorly-defined internal structure. The spherulites occur individually and as coalesced masses. Analcite in the arkose and analcimolite is silica-poor. Detrital minerals associated with the analcite include quartz, Naplagioclase, K-feldspar, and illite. Sericite is associated with analcite in the arkose and may also be authigenic. The analcite is least abundant at the base of the arkose unit and increases upward. The abundances of analcite and the detrital feldspars are inversely related. Analcite composition, distribution with respect to the feldsparas, presence of sericite, and the absence of a vitroclastic texture, suggests that analcite in the arkose was derived from a post-depositional dissolution of the feldspars. It is proposed that the analcite in the arkose and analcimolite were derived from different, but similar, parent materials