140 research outputs found
A Cellular Mechanism for Graded Persistent Activity in a Model Neuron and Its Implications in Working Memory
Synchronization of Excitatory Neurons with Strongly Heterogeneous Phase Responses
In many real-world oscillator systems, the phase response curves are highly
heterogeneous. However, dynamics of heterogeneous oscillator networks has not
been seriously addressed. We propose a theoretical framework to analyze such a
system by dealing explicitly with the heterogeneous phase response curves. We
develop a novel method to solve the self-consistent equations for order
parameters by using formal complex-valued phase variables, and apply our theory
to networks of in vitro cortical neurons. We find a novel state transition that
is not observed in previous oscillator network models.Comment: 4 pages, 3 figure
MiChao-HuaFen 1.0: A Specialized Pre-trained Corpus Dataset for Domain-specific Large Models
With the advancement of deep learning technologies, general-purpose large
models such as GPT-4 have demonstrated exceptional capabilities across various
domains. Nevertheless, there remains a demand for high-quality, domain-specific
outputs in areas like healthcare, law, and finance. This paper first evaluates
the existing large models for specialized domains and discusses their
limitations. To cater to the specific needs of certain domains, we introduce
the ``MiChao-HuaFen 1.0'' pre-trained corpus dataset, tailored for the news and
governmental sectors. The dataset, sourced from publicly available internet
data from 2022, underwent multiple rounds of cleansing and processing to ensure
high quality and reliable origins, with provisions for consistent and stable
updates. This dataset not only supports the pre-training of large models for
Chinese vertical domains but also aids in propelling deep learning research and
applications in related fields.Comment: 4 pages,2 figure
The role of virtual-assisted lung mapping 2.0 combining microcoils and dye marks in deep lung resection
Objectives: Virtual-assisted lung mapping 2.0 is a novel preoperative bronchoscopic lung mapping technique combining the multiple dye marks of conventional virtual-assisted lung mapping with intrabronchial microcoils to navigate thoracoscopic deep lung resection. This study's purpose was to evaluate the feasibility of virtual-assisted lung mapping 2.0 in resecting deeply located pulmonary nodules with adequate margins.
Methods: A multicenter, prospective single-arm study was performed from 2019 to 2020 in 8 institutions. The selection criteria were barely identifiable nodules requiring sublobar lung resections, nodules requiring resection lines reaching the inner 2/3 of the pulmonary lobe on computed tomography images in wedge resection, or the nodule center located in the inner 2/3 of the pulmonary lobe in wedge resection or segmentectomy. Resection margins larger than 2 cm or the nodule diameter were considered successful resection. Bronchoscopic placement of multiple dye marks and microcoil(s) was conducted 0 to 2 days before surgery.
Results: We analyzed 65 lesions in 64 patients. The diameter and depth of the targeted nodules and the minimum required resection depth reported as median (interquartile range) were 9 (7-13) mm, 11 (5-15) mm, and 30 (25-35) mm, respectively. Among 60 wedge resections and 5 segmentectomies, successful resection was achieved in 64 of 65 resections (98.5%; 95% confidence interval, 91.7-100). Among 75 microcoils placed, 3 showed major displacement after bronchoscopic placement. There were no severe adverse events associated with the virtual-assisted lung mapping procedure.
Conclusions: This study demonstrated that virtual-assisted lung mapping 2.0 can facilitate successful resections for deep pulmonary nodules, overcoming the limitations of conventional virtual-assisted lung mapping
Robustness of the noise-induced phase synchronization in a general class of limit cycle oscillators
We show that a wide class of uncoupled limit cycle oscillators can be
in-phase synchronized by common weak additive noise. An expression of the
Lyapunov exponent is analytically derived to study the stability of the
noise-driven synchronizing state. The result shows that such a synchronization
can be achieved in a broad class of oscillators with little constraint on their
intrinsic property. On the other hand, the leaky integrate-and-fire neuron
oscillators do not belong to this class, generating intermittent phase slips
according to a power low distribution of their intervals.Comment: 10 pages, 3 figure
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