Tetralogia de Fallot no Brasil: compreendendo a existência

Introduction: Tetralogy of Fallot involves four specific heart problems. Firstly, there is pulmonary stenosis, characterized by the narrowing of the pathway that carries blood from the heart to the lungs, hindering blood flow. Right ventricular hypertrophy is another characteristic, where the muscle of the right ventricle of the heart becomes thicker due to increased workload caused by pulmonary stenosis. Methodology: The present study adopted a descriptive epidemiological approach with the aim of analyzing cases of Tetralogy of Fallot among live births in Brazil from 2012 to 2021. Data collection utilized the Live Birth Information System (SINASC), made available by DATASUS. Results: In the group of individuals born with Tetralogy of Fallot, the analysis of variables reveals valuable information about demographic characteristics and perinatal conditions. Regarding the "Race/Ethnicity" variable, out of the 943 cases registered, 588 (62.35%) were classified as white, 51 (5.41%) as black, 10 (1.06%) as yellow, 267 (28.31%) as brown, and 27 (2.86%) had race/ethnicity recorded as unknown. Conclusion: A profound understanding of congenital heart diseases not only saves lives but also significantly improves the quality of life for affected individuals.Introdução: A Tetralogia de Fallot envolve quatro problemas cardíacos específicos. Em primeiro lugar, há a estenose pulmonar, caracterizada pelo estreitamento da via que conduz o sangue do coração para os pulmões, dificultando o fluxo sanguíneo. A hipertrofia ventricular direita é outra característica, onde o músculo do ventrículo direito do coração torna-se mais espesso devido ao aumento da carga de trabalho provocado pela estenose pulmonar. Metodologia: O presente estudo adotou uma abordagem epidemiológica descritiva com o objetivo de analisar os casos de Tetralogia de Fallot entre os nascidos vivos no Brasil no período de 2012 a 2021. Para a coleta de dados, utilizou-se o Sistema de Informações sobre Nascidos Vivos (SINASC), disponibilizado pelo DATASUS Resultado: No grupo de nascidos com Tetralogia de Fallot, a análise das variáveis revela informações valiosas sobre características demográficas e condições perinatais. Em relação à variável "Cor/Raça", dos 943 casos registrados, 588 (62,35%) eram classificados como brancos, 51 (5,41%) como pretos, 10 (1,06%) como amarelos, 267 (28,31%) como pardos, e 27 (2,86%) tiveram a cor/raça registrada como ignorada Conclusão: A compreensão profunda das cardiopatias congênitas não apenas salva vidas, mas também melhora significativamente a qualidade de vida dos indivíduos afetados

TaxonomyBrowser: a biodiversity data management system

Submitted by Sandra Infurna ([email protected]) on 2016-10-04T13:25:41Z No. of bitstreams: 1 pedro_estrela_etal_IOC_2011.pdf: 2361967 bytes, checksum: 12a473282a0a8ad9d6f5bbc8567f1d69 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2016-10-04T13:35:29Z (GMT) No. of bitstreams: 1 pedro_estrela_etal_IOC_2011.pdf: 2361967 bytes, checksum: 12a473282a0a8ad9d6f5bbc8567f1d69 (MD5)Made available in DSpace on 2016-10-04T13:35:29Z (GMT). No. of bitstreams: 1 pedro_estrela_etal_IOC_2011.pdf: 2361967 bytes, checksum: 12a473282a0a8ad9d6f5bbc8567f1d69 (MD5) Previous issue date: 2011Universidade Federal do Rio Grande do Sul. Instituto de Informática. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Instituto de Informática. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Instituto de Informática. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Departamento de Genética. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Instituto de Informática. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Instituto de Informática. Porto Alegre, RS, Brasil.This paper describes the main components of a biodiversity information system aimed at integrating visualization and data analysis tools with data management functions provided by relational databases. The system TaxonomyBrowser has the goal of aiding biologists in the management of data about specimens they collect in field work as well as serving to catalog specimens found in museums collections. The integration with map visualization and data analysis tools, through the Google Maps API and the R System, respectively, widens the application of the system

HER-2 and EGFR mRNA Expression and Its Relationship with Versican in Malignant Matrix-Producing Tumors of the Canine Mammary Gland

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2017-02-08T17:19:05Z No. of bitstreams: 1 Damasceno KA HER-2 and EGFR....pdf: 3066540 bytes, checksum: 8e901331c60dfdb84ee568e03ea2e44d (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2017-02-08T17:54:20Z (GMT) No. of bitstreams: 1 Damasceno KA HER-2 and EGFR....pdf: 3066540 bytes, checksum: 8e901331c60dfdb84ee568e03ea2e44d (MD5)Made available in DSpace on 2017-02-08T17:54:20Z (GMT). No. of bitstreams: 1 Damasceno KA HER-2 and EGFR....pdf: 3066540 bytes, checksum: 8e901331c60dfdb84ee568e03ea2e44d (MD5) Previous issue date: 2016Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Conselho Nacional de Desenvolvimento e Pesquisa (CNPq) and Fundação de amparo a pesquisa do Estado de Minas Gerais (FAPEMIG).Universidade Federal de Minas Gerais. Department of General Pathology. Biological Sciences Institute. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilUniversidade Federal de Minas Gerais. Department of General Pathology. Biological Sciences Institute. Belo Horizonte, MG, BrasilUniversidade Federal da Bahia. School of Veterinary Medicine and Zootechny. Department of Pathology and Clinics. Salvador, BA, BrazilUniversidade Federal de Minas Gerais. Department of General Pathology. Biological Sciences Institute. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Department of General Pathology. Biological Sciences Institute. Belo Horizonte, MG, BrasilInternational Center of Research in Cancer (CIPE). A.C. Camargo Cancer Center. São Paulo, SP, BrazilInternational Center of Research in Cancer (CIPE). A.C. Camargo Cancer Center. São Paulo, SP, BrazilUniversidade Federal de Minas Gerais. School of Pharmacy. Department of Clinical and Toxicological Analyses. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Department of General Pathology. Biological Sciences Institute. Belo Horizonte, MG, BrasilVersican expression promotes tumor growth by destabilizing focal cell contacts, thus impeding cell adhesion and facilitating cell migration. It not only presents or recruits molecules to the cell surface, but also modulates gene expression levels and coordinates complex signal pathways. Previously, we suggested that the interaction between versican and human epidermal growth factor receptors may be directly associated with tumor aggressiveness. Thus, the expression of EGFR and HER-2 in these neoplasms may contribute to a better understanding of the progression mechanisms in malignant mammary tumors. The purpose of this study was to correlate the gene and protein expressions of EGFR and HER2 by RNA In Situ Hybridization (ISH) and immunohistochemistry (IHC), respectively, and their relationship with the versican expression in carcinomas in mixed tumors and carcinosarcomas of the canine mammary gland. The results revealed that EGFR mRNA expression showed a significant difference between in situ and invasive carcinomatous areas in low and high versican expression groups. Identical results were observed in HER-2 mRNA expression. In immunohistochemistry analysis, neoplasms with low versican expression showed greater EGFR immunostaining in the in situ areas than in invasive areas, even as the group presenting high versican expression displayed greater EGFR and HER-2 staining in in situ areas. Significant EGFR and HER-2 mRNA and protein expressions in in situ carcinomatous sites relative to invasive areas suggest that these molecules play a role during the early stages of tumor progression

EGFR and HER-2 expression by immunohistochemistry (IHC) and their mRNA by <i>in situ</i> hybridization (ISH) in canine mammary carcinomas in mixed tumors and carcinosarcomas.

<p>EGFR and HER-2 expression by immunohistochemistry (IHC) and their mRNA by <i>in situ</i> hybridization (ISH) in canine mammary carcinomas in mixed tumors and carcinosarcomas.</p

Clinicopathological characteristics of canine mammary carcinomas in mixed tumors (CMTs) and carcinosarcomas (CSs).

<p>Clinicopathological characteristics of canine mammary carcinomas in mixed tumors (CMTs) and carcinosarcomas (CSs).</p

<i>HER-2</i> and <i>EGFR</i> mRNA Expression and Its Relationship with Versican in Malignant Matrix-Producing Tumors of the Canine Mammary Gland - Fig 2

<p>(A)(B) <i>EGFR</i> and (C)(D) <i>HER-2</i> mRNA expression in canine mammary tumours. Difference between <i>in situ</i> (IS) and invasive (IN) areas in versican low (G1) and high (G2) expression groups. Wilcoxon test. *p<0.05 ***p<0.001.</p

Differences versican expression in <i>in situ</i> (IS) and invasive (IN) carcinomatous areas in versican low (G1) and high (G2) expression groups in canine mammary tumours.

<p>Wilcoxon test.</p

RNA-ISH analysis of <i>EGFR</i> gene expression in canine mammary tumours showing cytoplasmatic dots.

<p>(A) <i>In situ</i> carcinomatous areas showing RNA ISH score 3: in carcinomas in mixed tumours. (B) Invasive carcinomatous areas showing RNA ISH score 0 in carcinomas in mixed tumours (dots indicated by red arrow). (C) <i>In situ</i> carcinomatous areas showing RNA ISH score 2 in carcinosarcoma. (D) Invasive carcinomatous areas showing RNA ISH score 1 in carcinosarcoma (magnification x60).</p