108 research outputs found
Дискусійні питання історії ЗУНР
У статті аналізуються питання, які все ще залишаються в історіографії Західноукраїнської Народної Республіки. Автор звертає увагу на контроверсійні точки зору щодо революційних подій, які відбулися 1 листопада 1918 р. у Львові, стосовно часу існування ЗУНР, Акту злуки УНР та ЗУНР, причин поразки Української Галицької армії тощо.The author of the article analyses the questions that are still disputable in modern
Ukrainian historiography. The author attracts our attention to the controversial points
of view concerning the type of revolutionary events which took place on the 1 st of
November 1918 in Lviv, concerning the time of WUPR existence, concerning the Act of
Unification of Western Ukrainian People’s Republic end Ukrainian People’s Republic ,
concerning the reasons of the defeat of Ukrainian army, etc
Potent and Broad-Spectrum Antimicrobial Activity of Analogs from the Scorpion Peptide Stigmurin
Scorpion venom constitutes a rich source of biologically active compounds with high potential for therapeutic and biotechnological applications that can be used as prototypes for the design of new drugs. The aim of this study was to characterize the structural conformation, evaluate the antimicrobial activity, and gain insight into the possible action mechanism underlying it, for two new analog peptides of the scorpion peptide Stigmurin, named StigA25 and StigA31. The amino acid substitutions in the native sequence for lysine residues resulted in peptides with higher positive net charge and hydrophobicity, with an increase in the theoretical helical content. StigA25 and StigA31 showed the capacity to modify their structural conformation according to the environment, and were stable to pH and temperature variation-results similar to the native peptide. Both analog peptides demonstrated broad-spectrum antimicrobial activity in vitro, showing an effect superior to that of the native peptide, being non-hemolytic at the biologically active concentrations. Therefore, this study demonstrates the therapeutic potential of the analog peptides from Stigmurin and the promising approach of rational drug design based on scorpion venom peptide to obtain new anti-infective agents.publishersversionpublishe
SIMANIHOT: A PROCESS-BASED MODEL FOR SIMULATING GROWTH, DEVELOPMENT AND PRODUCTIVITY OF CASSAVA
Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain
Given the importance of the kinin B1 receptor in insulin and leptin hormonal regulation, which in turn is crucial in maternal adaptations to ensure nutrient supply to the fetus, we investigated the role of this receptor in maternal metabolism and fetoplacental development. Wild-type and kinin B1 receptor-deficient (B1KO) female mice were mated with male mice of the opposite genotype. Consequently, the entire litter was heterozygous for kinin B1 receptor, ensuring that there would be no influence of offspring genotype on the maternal phenotype. Maternal kinin B1 receptor blockade reduces adiponectin secretion by adipose tissue ex vivo, consistent with lower adiponectin levels in pregnant B1KO mice. Furthermore, fasting insulinemia also increased, which was associated with placental insulin resistance, reduced placental glycogen accumulation, and heavier offspring. Therefore, we propose the combination of chronic hyperinsulinemia and reduced adiponectin secretion in B1KO female mice create a maternal obesogenic environment that results in heavier pups
Desembarque e esforço de pesca da frota pesqueira comercial de Manicoré (Médio Rio Madeira), Amazonas, Brasil
Estimating cassava yield in future IPCC climate scenarios for the Rio Grande do Sul State, Brazil
Efeitos genéticos e de ambiente sobre produção de leite e intervalo de partos em rebanhos leiteiros monitorados por sistema de informação
Tratamento da infecção pelo vírus da hepatite C em candidatos a transplante renal submetidos a diálise: impacto orçamentário no SUS
- …