Adult attachment style across individuals and role-relationships: Avoidance is relationship-specific, but anxiety shows greater generalizability

A generalisability study examined the hypotheses that avoidant attachment, reflecting the representation of others, should be more relationship-specific (vary across relationships more than across individuals), while attachment anxiety, reflecting self-representation, should be more generalisable across a person’s relationships. College students responded to 6-item questionnaire measures of these variables for 5 relationships (mother, father, best same-gender friend, romantic partner or best opposite-gender friend, other close person), on 3 (N = 120) or 2 (N = 77) occasions separated by a few weeks. Results supported the hypotheses, with the person variance component being larger than the relationship-specific component for anxiety, and the opposite happening for avoidance. Anxiety therefore seems not to be as relationship-specific as previous research suggested. Possible reasons for discrepancies between the current and previous studies are discussed

American Society of Hematology 2020 guidelines for sickle cell disease: Prevention, diagnosis, and treatment of cerebrovascular disease in children and adults

BACKGROUND: Central nervous system (CNS) complications are among the most common, devastating sequelae of sickle cell disease (SCD) occurring throughout the lifespan.OBJECTIVE: These evidence-based guidelines of the American Society of Hematology are intended to support the SCD community in decisions about prevention, diagnosis, and treatment of the most common neurological morbidities in SCD.METHODS: The Mayo Evidence-Based Practice Research Program supported the guideline development process, including updating or performing systematic evidence reviews. The panel used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, including GRADE evidence-to-decision frameworks, to assess evidence and make recommendations.RESULTS: The panel placed a higher value on maintaining cognitive function than on being alive with significantly less than baseline cognitive function. The panel developed 19 recommendations with evidence-based strategies to prevent, diagnose, and treat CNS complications of SCD in low-middle- and high-income settings.CONCLUSIONS: Three of 19 recommendations immediately impact clinical care. These recommendations include: use of transcranial Doppler ultrasound screening and hydroxyurea for primary stroke prevention in children with hemoglobin SS (HbSS) and hemoglobin Sβ0 (HbSβ0) thalassemia living in low-middle-income settings; surveillance for developmental delay, cognitive impairments, and neurodevelopmental disorders in children; and use of magnetic resonance imaging of the brain without sedation to detect silent cerebral infarcts at least once in early-school-age children and once in adults with HbSS or HbSβ0 thalassemia. Individuals with SCD, their family members, and clinicians should become aware of and implement these recommendations to reduce the burden of CNS complications in children and adults with SCD.</p

Efficient exploration of unknown indoor environments using a team of mobile robots

Whenever multiple robots have to solve a common task, they need to coordinate their actions to carry out the task efficiently and to avoid interferences between individual robots. This is especially the case when considering the problem of exploring an unknown environment with a team of mobile robots. To achieve efficient terrain coverage with the sensors of the robots, one first needs to identify unknown areas in the environment. Second, one has to assign target locations to the individual robots so that they gather new and relevant information about the environment with their sensors. This assignment should lead to a distribution of the robots over the environment in a way that they avoid redundant work and do not interfere with each other by, for example, blocking their paths. In this paper, we address the problem of efficiently coordinating a large team of mobile robots. To better distribute the robots over the environment and to avoid redundant work, we take into account the type of place a potential target is located in (e.g., a corridor or a room). This knowledge allows us to improve the distribution of robots over the environment compared to approaches lacking this capability. To autonomously determine the type of a place, we apply a classifier learned using the AdaBoost algorithm. The resulting classifier takes laser range data as input and is able to classify the current location with high accuracy. We additionally use a hidden Markov model to consider the spatial dependencies between nearby locations. Our approach to incorporate the information about the type of places in the assignment process has been implemented and tested in different environments. The experiments illustrate that our system effectively distributes the robots over the environment and allows them to accomplish their mission faster compared to approaches that ignore the place labels

Kinetics and Mechanism of Hydroxyapatite Crystal Dissolution in Weak Acid Buffers Using the Rotating Disk Method

The dissolution rates of synthetic hydroxyapatite pellets under sink conditions were measured using the rotating disk method. The experimental data were analyzed by means of a physical model that yielded an ionic activity product of KHAP = a10Ca2+ a6 PO4 3- a2OH- = 1 × 10-124.5±1.0 that was found to govern the dissolution reaction. Also, a surface resistance factor of k' equal to about 174 sec/cm was deduced from the data.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67157/2/10.1177_00220345760550033201.pd

Direct measurement of the14N(p, γ)15O S factor

The 14(p, γ)15O reaction regulates the rate of energy generation in the stellar CN cycle. Because discrepancies have been found in the analysis and interpretation of previous capture data, we have measured the 14N(p, γ)15O excitation function for energies in the range Eplab = 155-524 keV. Fits of these data using K-matrix theory yield a value for the S factor at zero energy of 1.68 ±0.09(stat) ± 0.16(syst) keVb, which is significantly smaller than the previous result. The corresponding reduction in the stellar reaction rate for 14N(p, γ)15O has a number of interesting consequences, including an impact on estimates for the age of the Galaxy derived from globular clusters

Search for a resonance in the 14N(p, γ)15O reaction at Ep = 127 keV

The 14N(p, γ)15O reaction regulates the energy produced by the CN cycle in main-sequence stars and in red giants. Recently, preliminary evidence was presented for a new resonance in this reaction, which would significantly increase the reaction rate for temperatures near 108 K. We have attempted to confirm this result and find no indication of a resonance near Eplab = 127 keV. Our upper limit on its strength is ω γ≤32 neV (95% C.L.), which is more than 2 orders of magnitude below the previously reported value

Short Gamma Ray Bursts as possible electromagnetic counterpart of coalescing binary systems

Coalescing binary systems, consisting of two collapsed objects, are among the most promising sources of high frequency gravitational waves signals detectable, in principle, by ground-based interferometers. Binary systems of Neutron Star or Black Hole/Neutron Star mergers should also give rise to short Gamma Ray Bursts, a subclass of Gamma Ray Bursts. Short-hard-Gamma Ray Bursts might thus provide a powerful way to infer the merger rate of two-collapsed object binaries. Under the hypothesis that most short Gamma Ray Bursts originate from binaries of Neutron Star or Black Hole/Neutron Star mergers, we outline here the possibility to associate short Gamma Ray Bursts as electromagnetic counterpart of coalescing binary systems.Comment: 4 pages, 1 figur

Extragalactic Inverse Compton Light from Dark Matter Annihilation and the Pamela Positron Excess

We calculate the extragalactic diffuse emission originating from the up-scattering of cosmic microwave photons by energetic electrons and positrons produced in particle dark matter annihilation events at all redshifts and in all halos. We outline the observational constraints on this emission and we study its dependence on both the particle dark matter model (including the particle mass and its dominant annihilation final state) and on assumptions on structure formation and on the density profile of halos. We find that for low-mass dark matter models, data in the X-ray band provide the most stringent constraints, while the gamma-ray energy range probes models featuring large masses and pair-annihilation rates, and a hard spectrum for the injected electrons and positrons. Specifically, we point out that the all-redshift, all-halo inverse Compton emission from many dark matter models that might provide an explanation to the anomalous positron fraction measured by the Pamela payload severely overproduces the observed extragalactic gamma-ray background.Comment: Version accepted for publication in JCAP, one new figure and text added; 19 pages, 5 figure

Monopole characteristics in various Abelian gauges

Renormalization group (RG) smoothing is employed on the lattice to investigate and to compare the monopole structure of the SU(2) vacuum as seen in different gauges (maximally Abelian (MAG), Polyakov loop (PG) and Laplacian gauge (LG)). Physically relevant types of monopoles (LG and MAG) are distinguished by their behavior near the deconfining phase transition. For the LG, Abelian projection reproduces well the gauge independent monopole structure encoded in an auxiliary Higgs field. Density and localization properties of monopoles, their non-Abelian action and topological charge are studied. Results are presented confirming the Abelian dominance with respect to the non-perturbative static potential for all gauges considered.Comment: 36 pages, 12 figure

Stu2 uses a 15-nm parallel coiled coil for kinetochore localization and concomitant regulation of the mitotic spindle

XMAP215/Dis1 family proteins are potent microtubule polymerases, critical for mitotic spindle structure and dynamics. While microtubule polymerase activity is driven by an N-terminal tumor overexpressed gene (TOG) domain array, proper cellular localization is a requisite for full activity and is mediated by a C-terminal domain. Structural insight into the C-terminal domain's architecture and localization mechanism remain outstanding. We present the crystal structure of the Saccharomyces cerevisiae Stu2 C-terminal domain, revealing a 15-nm parallel homodimeric coiled coil. The parallel architecture of the coiled coil has mechanistic implications for the arrangement of the homodimer's N-terminal TOG domains during microtubule polymerization. The coiled coil has two spatially distinct conserved regions: CRI and CRII. Mutations in CRI and CRII perturb the distribution and localization of Stu2 along the mitotic spindle and yield defects in spindle morphology including increased frequencies of mispositioned and fragmented spindles. Collectively, these data highlight roles for the Stu2 dimerization domain as a scaffold for factor binding that optimally positions Stu2 on the mitotic spindle to promote proper spindle structure and dynamics