Lithospheric failure on Venus

We develop a predictive model which has the ability to explain a postulated style of episodic plate tectonics on Venus, through the periodic occurrence of lithospheric subduction events. Present-day incipient subduction zones are associated with the existence of arcuate trenches on the Venusian lithosphere. These trenches resemble terrestrial subduction zones, and occur at the rim of coronae, uplift features thought to be due to deep-mantle convective plumes. The model we adopt represents the lithosphere as the thermal boundary layer which lies above a convective plume. We assume a temperature-dependent nonlinear viscoelastic rheology, and we assume a stress-based criterion for plastic yield. In developing this latter criterion, we are led to a re-interpretation of the strength envelope which is commonly used in analysing lithospheric stress, and we propose that the plastic yield strength has meaning (and is finite) below the lithosphere, using behaviour in the Earth as our 'laboratory' justification for this view. An inferred yield stress on the Earth is ca. 300 bar (30 MPa). Our model then shows that a thickening lithosphere becomes progressively more fluid as the stresses induced by the buoyant convective plume become large. Failure occurs when the effective lithosphere viscosity becomes equal to that of the underlying mantle. We show that reasonable expected values of yield stress in the range 100-200 bar (10-20 MPa) for Venusian mantle rocks are consistent within the framework of the model with radii of coronal trenches in the range 100-1200 km, and with the approximate time (200-800 Myr) which they may take to develop

Proton-induced noise in digicons

The Space Telescope, which carries four Digicons, will pass several times per day through a low-altitude portion of the radiation belt called the South Atlantic Anomaly. This is expected to create interference in what is otherwise anticipated to be a noise-free device. Two essential components of the Digicon, the semiconductor diode array and the UV transmitting window, generate noise when subjected to medium-energy proton radiation, a primary component of the belt. These trapped protons, having energies ranging from 2 to 400 Mev and fluences at the Digicon up to 4,000 P+/sec-sq cm, pass through both the window and the diode array, depositing energy in each. In order to evaluate the effect of these protons, engineering test models of Digicon tubes to be flown on the High Resolution Spectrograph were irradiated with low-flux monoenergetic proton beams at the University of Maryland cyclotron. Electron-hole pairs produced by the protons passing through the diodes or the surrounding bulk caused a background count rate. This is the result of holes diffusing over a distance of many diode spacings, causing counts to be triggered simultaneously in the output circuits of several adjacent diodes. Pulse-height spectra of these proton-induced counts indicate that most of the bulk-related counts overlap the single photoelectron peak. A geometrical model will be presented of the charge collection characteristics of the diode array that accounts for most of the observed effects

Reducing Broiler Bruising on the Farm.

4 p

Continuing Progress on a Lattice QCD Software Infrastructure

We report on the progress of the software effort in the QCD Application Area of SciDAC. In particular, we discuss how the software developed under SciDAC enabled the aggressive exploitation of leadership computers, and we report on progress in the area of QCD software for multi-core architectures.Comment: 5 Pages, to appear in the Proceedings of SciDAC 2008 conference, (Seattle, July 13-17, 2008), Conference Poster Presentation Proceeding

Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep

We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary gonadal (HPG) function in sheep. This study investigated whether exposure to ECs only during preconceptional period or only during pregnancy perturbed key regulatory genes within the hypothalamus and pituitary gland and whether these effects were different from chronic (life-long) exposure to biosolid ECs. The findings demonstrate that the timing and duration of maternal EC exposure influences the subsequent effects on the fetal neuroendocrine system in a sex-specific manner. Maternal exposure prior to conception or during pregnancy only, altered the expression of key fetal neuroendocrine regulatory systems such as GnRH and kisspeptin to a greater extent than when maternal exposure was ‘life-long’. Furthermore, hypothalamic gene expression was affected to a greater extent in males than in females, and following EC exposure, male fetuses expressed more “female-like” mRNA levels for some key neuroendocrine genes. This is the first study to show that “real-life” maternal exposure to low levels of a complex cocktail of chemicals prior to conception can subsequently affect the developing fetal neuroendocrine system. These findings demonstrate that the developing neuroendocrine system is sensitive to EC mixtures in a sex-dimorphic manner likely to predispose to reproductive dysfunction in later life

Effective elements of cognitive behaviour therapy for psychosis: results of a novel type of subgroup analysis based on principal stratification

Background. Meta-analyses show that cognitive behaviour therapy for psychosis (CBT-P) improves distressing positive symptoms. However, it is a complex intervention involving a range of techniques. No previous study has assessed the delivery of the different elements of treatment and their effect on outcome. Our aim was to assess the differential effect of type of treatment delivered on the effectiveness of CBT-P, using novel statistical methodology. Method. The Psychological Prevention of Relapse in Psychosis (PRP) trial was a multi-centre randomized controlled trial (RCT) that compared CBT-P with treatment as usual (TAU). Therapy was manualized, and detailed evaluations of therapy delivery and client engagement were made. Follow-up assessments were made at 12 and 24 months. In a planned analysis, we applied principal stratification (involving structural equation modelling with finite mixtures) to estimate intention-to-treat (ITT) effects for subgroups of participants, defined by qualitative and quantitative differences in receipt of therapy, while maintaining the constraints of randomization. Results. Consistent delivery of full therapy, including specific cognitive and behavioural techniques, was associated with clinically and statistically significant increases in months in remission, and decreases in psychotic and affective symptoms. Delivery of partial therapy involving engagement and assessment was not effective. Conclusions. Our analyses suggest that CBT-P is of significant benefit on multiple outcomes to patients able to engage in the full range of therapy procedures. The novel statistical methods illustrated in this report have general application to the evaluation of heterogeneity in the effects of treatment